Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation.
Foreign body reaction (FBR) to implanted biomaterials and medical devices is common and can compromise the function of implants or cause complications. For example, in cell encapsulation, cellular overgrowth (CO) and fibrosis around the cellular constructs can reduce the mass transfer of oxygen, nut...
Main Authors: | , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | unknown |
Published: |
eScholarship, University of California
2019
|
Subjects: | |
Online Access: | https://escholarship.org/uc/item/8pt251fm |
id |
ftcdlib:oai:escholarship.org:ark:/13030/qt8pt251fm |
---|---|
record_format |
openpolar |
spelling |
ftcdlib:oai:escholarship.org:ark:/13030/qt8pt251fm 2023-11-12T04:15:47+01:00 Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation. Liu, Qingsheng Chiu, Alan Wang, Long-Hai An, Duo Zhong, Monica Smink, Alexandra de Haan, Bart de Vos, Paul Keane, Kevin Vegge, Andreas Chen, Esther Song, Wei Flanders, James Rescan, Claude Grunnet, Lars Wang, Xi Ma, Minglin Liu, Wendy 2019-11-20 application/pdf https://escholarship.org/uc/item/8pt251fm unknown eScholarship, University of California qt8pt251fm https://escholarship.org/uc/item/8pt251fm public Nature Communications, vol 10, iss 1 Alginates Animals Betaine Carbonic Acid Cell Encapsulation Cell Proliferation Diabetes Mellitus Experimental Type 1 Dogs Fibrosis Foreign-Body Reaction Islets of Langerhans Transplantation Mice Rats Swine article 2019 ftcdlib 2023-10-23T18:04:26Z Foreign body reaction (FBR) to implanted biomaterials and medical devices is common and can compromise the function of implants or cause complications. For example, in cell encapsulation, cellular overgrowth (CO) and fibrosis around the cellular constructs can reduce the mass transfer of oxygen, nutrients and metabolic wastes, undermining cell function and leading to transplant failure. Therefore, materials that mitigate FBR or CO will have broad applications in biomedicine. Here we report a group of zwitterionic, sulfobetaine (SB) and carboxybetaine (CB) modifications of alginates that reproducibly mitigate the CO of implanted alginate microcapsules in mice, dogs and pigs. Using the modified alginates (SB-alginates), we also demonstrate improved outcome of islet encapsulation in a chemically-induced diabetic mouse model. These zwitterion-modified alginates may contribute to the development of cell encapsulation therapies for type 1 diabetes and other hormone-deficient diseases. Article in Journal/Newspaper Carbonic acid University of California: eScholarship |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Alginates Animals Betaine Carbonic Acid Cell Encapsulation Cell Proliferation Diabetes Mellitus Experimental Type 1 Dogs Fibrosis Foreign-Body Reaction Islets of Langerhans Transplantation Mice Rats Swine |
spellingShingle |
Alginates Animals Betaine Carbonic Acid Cell Encapsulation Cell Proliferation Diabetes Mellitus Experimental Type 1 Dogs Fibrosis Foreign-Body Reaction Islets of Langerhans Transplantation Mice Rats Swine Liu, Qingsheng Chiu, Alan Wang, Long-Hai An, Duo Zhong, Monica Smink, Alexandra de Haan, Bart de Vos, Paul Keane, Kevin Vegge, Andreas Chen, Esther Song, Wei Flanders, James Rescan, Claude Grunnet, Lars Wang, Xi Ma, Minglin Liu, Wendy Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation. |
topic_facet |
Alginates Animals Betaine Carbonic Acid Cell Encapsulation Cell Proliferation Diabetes Mellitus Experimental Type 1 Dogs Fibrosis Foreign-Body Reaction Islets of Langerhans Transplantation Mice Rats Swine |
description |
Foreign body reaction (FBR) to implanted biomaterials and medical devices is common and can compromise the function of implants or cause complications. For example, in cell encapsulation, cellular overgrowth (CO) and fibrosis around the cellular constructs can reduce the mass transfer of oxygen, nutrients and metabolic wastes, undermining cell function and leading to transplant failure. Therefore, materials that mitigate FBR or CO will have broad applications in biomedicine. Here we report a group of zwitterionic, sulfobetaine (SB) and carboxybetaine (CB) modifications of alginates that reproducibly mitigate the CO of implanted alginate microcapsules in mice, dogs and pigs. Using the modified alginates (SB-alginates), we also demonstrate improved outcome of islet encapsulation in a chemically-induced diabetic mouse model. These zwitterion-modified alginates may contribute to the development of cell encapsulation therapies for type 1 diabetes and other hormone-deficient diseases. |
format |
Article in Journal/Newspaper |
author |
Liu, Qingsheng Chiu, Alan Wang, Long-Hai An, Duo Zhong, Monica Smink, Alexandra de Haan, Bart de Vos, Paul Keane, Kevin Vegge, Andreas Chen, Esther Song, Wei Flanders, James Rescan, Claude Grunnet, Lars Wang, Xi Ma, Minglin Liu, Wendy |
author_facet |
Liu, Qingsheng Chiu, Alan Wang, Long-Hai An, Duo Zhong, Monica Smink, Alexandra de Haan, Bart de Vos, Paul Keane, Kevin Vegge, Andreas Chen, Esther Song, Wei Flanders, James Rescan, Claude Grunnet, Lars Wang, Xi Ma, Minglin Liu, Wendy |
author_sort |
Liu, Qingsheng |
title |
Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation. |
title_short |
Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation. |
title_full |
Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation. |
title_fullStr |
Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation. |
title_full_unstemmed |
Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation. |
title_sort |
zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation. |
publisher |
eScholarship, University of California |
publishDate |
2019 |
url |
https://escholarship.org/uc/item/8pt251fm |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
Nature Communications, vol 10, iss 1 |
op_relation |
qt8pt251fm https://escholarship.org/uc/item/8pt251fm |
op_rights |
public |
_version_ |
1782333058832138240 |