Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice
Locomotion in mammals relies on a central pattern-generating circuitry of spinal interneurons established during development that coordinates limb movement. These networks produce left-right alternation of limbs as well as coordinated activation of flexor and extensor muscles. Here we show that a pr...
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ftcdlib:oai:escholarship.org:ark:/13030/qt8ph9b5b8 2023-10-25T01:39:50+02:00 Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice Andersson, Lisa S Larhammar, Martin Memic, Fatima Wootz, Hanna Schwochow, Doreen Rubin, Carl-Johan Patra, Kalicharan Arnason, Thorvaldur Wellbring, Lisbeth Hjälm, Göran Imsland, Freyja Petersen, Jessica L McCue, Molly E Mickelson, James R Cothran, Gus Ahituv, Nadav Roepstorff, Lars Mikko, Sofia Vallstedt, Anna Lindgren, Gabriella Andersson, Leif Kullander, Klas 642 - 646 2012-08-01 application/pdf https://escholarship.org/uc/item/8ph9b5b8 unknown eScholarship, University of California qt8ph9b5b8 https://escholarship.org/uc/item/8ph9b5b8 public Nature, vol 488, iss 7413 Veterinary Sciences Agricultural Veterinary and Food Sciences Biological Sciences Spinal Cord Injury Bioengineering Neurodegenerative Genetics Amino Acid Sequence Animals Codon Nonsense Gait Gene Expression Profiling Gene Frequency Horses Iceland Mice Molecular Sequence Data Mutation Neural Pathways Psychomotor Performance Spinal Cord Transcription Factors General Science & Technology article 2012 ftcdlib 2023-09-25T18:04:15Z Locomotion in mammals relies on a central pattern-generating circuitry of spinal interneurons established during development that coordinates limb movement. These networks produce left-right alternation of limbs as well as coordinated activation of flexor and extensor muscles. Here we show that a premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses. The mutation is permissive for the ability to perform alternate gaits and has a favourable effect on harness racing performance. Examination of wild-type and Dmrt3-null mice demonstrates that Dmrt3 is expressed in the dI6 subdivision of spinal cord neurons, takes part in neuronal specification within this subdivision, and is critical for the normal development of a coordinated locomotor network controlling limb movements. Our discovery positions Dmrt3 in a pivotal role for configuring the spinal circuits controlling stride in vertebrates. The DMRT3 mutation has had a major effect on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation. Article in Journal/Newspaper Iceland University of California: eScholarship |
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Open Polar |
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University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Veterinary Sciences Agricultural Veterinary and Food Sciences Biological Sciences Spinal Cord Injury Bioengineering Neurodegenerative Genetics Amino Acid Sequence Animals Codon Nonsense Gait Gene Expression Profiling Gene Frequency Horses Iceland Mice Molecular Sequence Data Mutation Neural Pathways Psychomotor Performance Spinal Cord Transcription Factors General Science & Technology |
spellingShingle |
Veterinary Sciences Agricultural Veterinary and Food Sciences Biological Sciences Spinal Cord Injury Bioengineering Neurodegenerative Genetics Amino Acid Sequence Animals Codon Nonsense Gait Gene Expression Profiling Gene Frequency Horses Iceland Mice Molecular Sequence Data Mutation Neural Pathways Psychomotor Performance Spinal Cord Transcription Factors General Science & Technology Andersson, Lisa S Larhammar, Martin Memic, Fatima Wootz, Hanna Schwochow, Doreen Rubin, Carl-Johan Patra, Kalicharan Arnason, Thorvaldur Wellbring, Lisbeth Hjälm, Göran Imsland, Freyja Petersen, Jessica L McCue, Molly E Mickelson, James R Cothran, Gus Ahituv, Nadav Roepstorff, Lars Mikko, Sofia Vallstedt, Anna Lindgren, Gabriella Andersson, Leif Kullander, Klas Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice |
topic_facet |
Veterinary Sciences Agricultural Veterinary and Food Sciences Biological Sciences Spinal Cord Injury Bioengineering Neurodegenerative Genetics Amino Acid Sequence Animals Codon Nonsense Gait Gene Expression Profiling Gene Frequency Horses Iceland Mice Molecular Sequence Data Mutation Neural Pathways Psychomotor Performance Spinal Cord Transcription Factors General Science & Technology |
description |
Locomotion in mammals relies on a central pattern-generating circuitry of spinal interneurons established during development that coordinates limb movement. These networks produce left-right alternation of limbs as well as coordinated activation of flexor and extensor muscles. Here we show that a premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses. The mutation is permissive for the ability to perform alternate gaits and has a favourable effect on harness racing performance. Examination of wild-type and Dmrt3-null mice demonstrates that Dmrt3 is expressed in the dI6 subdivision of spinal cord neurons, takes part in neuronal specification within this subdivision, and is critical for the normal development of a coordinated locomotor network controlling limb movements. Our discovery positions Dmrt3 in a pivotal role for configuring the spinal circuits controlling stride in vertebrates. The DMRT3 mutation has had a major effect on the diversification of the domestic horse, as the altered gait characteristics of a number of breeds apparently require this mutation. |
format |
Article in Journal/Newspaper |
author |
Andersson, Lisa S Larhammar, Martin Memic, Fatima Wootz, Hanna Schwochow, Doreen Rubin, Carl-Johan Patra, Kalicharan Arnason, Thorvaldur Wellbring, Lisbeth Hjälm, Göran Imsland, Freyja Petersen, Jessica L McCue, Molly E Mickelson, James R Cothran, Gus Ahituv, Nadav Roepstorff, Lars Mikko, Sofia Vallstedt, Anna Lindgren, Gabriella Andersson, Leif Kullander, Klas |
author_facet |
Andersson, Lisa S Larhammar, Martin Memic, Fatima Wootz, Hanna Schwochow, Doreen Rubin, Carl-Johan Patra, Kalicharan Arnason, Thorvaldur Wellbring, Lisbeth Hjälm, Göran Imsland, Freyja Petersen, Jessica L McCue, Molly E Mickelson, James R Cothran, Gus Ahituv, Nadav Roepstorff, Lars Mikko, Sofia Vallstedt, Anna Lindgren, Gabriella Andersson, Leif Kullander, Klas |
author_sort |
Andersson, Lisa S |
title |
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice |
title_short |
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice |
title_full |
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice |
title_fullStr |
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice |
title_full_unstemmed |
Mutations in DMRT3 affect locomotion in horses and spinal circuit function in mice |
title_sort |
mutations in dmrt3 affect locomotion in horses and spinal circuit function in mice |
publisher |
eScholarship, University of California |
publishDate |
2012 |
url |
https://escholarship.org/uc/item/8ph9b5b8 |
op_coverage |
642 - 646 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Nature, vol 488, iss 7413 |
op_relation |
qt8ph9b5b8 https://escholarship.org/uc/item/8ph9b5b8 |
op_rights |
public |
_version_ |
1780735384022417408 |