Genomic Underpinnings of Population Persistence in Isle Royale Moose
Island ecosystems provide natural laboratories to assess the impacts of isolation on population persistence. However, most studies of persistence have focused on a single species, without comparisons to other organisms they interact with in the ecosystem. The case study of moose and gray wolves on I...
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2023
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ftcdlib:oai:escholarship.org:ark:/13030/qt8nf6q45n 2023-11-12T04:00:21+01:00 Genomic Underpinnings of Population Persistence in Isle Royale Moose Kyriazis, Christopher C Beichman, Annabel C Brzeski, Kristin E Hoy, Sarah R Peterson, Rolf O Vucetich, John A Vucetich, Leah M Lohmueller, Kirk E Wayne, Robert K Nielsen, Rasmus msad021 2023-02-03 application/pdf https://escholarship.org/uc/item/8nf6q45n unknown eScholarship, University of California qt8nf6q45n https://escholarship.org/uc/item/8nf6q45n CC-BY Molecular Biology and Evolution, vol 40, iss 2 Biological Sciences Ecology Evolutionary Biology Genetics Human Genome Animals Ecosystem Wolves Deer Genome Genomics Alces alces bottlenecks genetic load inbreeding depression purging Biochemistry and Cell Biology article 2023 ftcdlib 2023-10-16T18:04:54Z Island ecosystems provide natural laboratories to assess the impacts of isolation on population persistence. However, most studies of persistence have focused on a single species, without comparisons to other organisms they interact with in the ecosystem. The case study of moose and gray wolves on Isle Royale allows for a direct contrast of genetic variation in isolated populations that have experienced dramatically differing population trajectories over the past decade. Whereas the Isle Royale wolf population recently declined nearly to extinction due to severe inbreeding depression, the moose population has thrived and continues to persist, despite having low genetic diversity and being isolated for ∼120 years. Here, we examine the patterns of genomic variation underlying the continued persistence of the Isle Royale moose population. We document high levels of inbreeding in the population, roughly as high as the wolf population at the time of its decline. However, inbreeding in the moose population manifests in the form of intermediate-length runs of homozygosity suggestive of historical inbreeding and purging, contrasting with the long runs of homozygosity observed in the smaller wolf population. Using simulations, we confirm that substantial purging has likely occurred in the moose population. However, we also document notable increases in genetic load, which could eventually threaten population viability over the long term. Overall, our results demonstrate a complex relationship between inbreeding, genetic diversity, and population viability that highlights the use of genomic datasets and computational simulation tools for understanding the factors enabling persistence in isolated populations. Article in Journal/Newspaper Alces alces University of California: eScholarship |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Biological Sciences Ecology Evolutionary Biology Genetics Human Genome Animals Ecosystem Wolves Deer Genome Genomics Alces alces bottlenecks genetic load inbreeding depression purging Biochemistry and Cell Biology |
spellingShingle |
Biological Sciences Ecology Evolutionary Biology Genetics Human Genome Animals Ecosystem Wolves Deer Genome Genomics Alces alces bottlenecks genetic load inbreeding depression purging Biochemistry and Cell Biology Kyriazis, Christopher C Beichman, Annabel C Brzeski, Kristin E Hoy, Sarah R Peterson, Rolf O Vucetich, John A Vucetich, Leah M Lohmueller, Kirk E Wayne, Robert K Genomic Underpinnings of Population Persistence in Isle Royale Moose |
topic_facet |
Biological Sciences Ecology Evolutionary Biology Genetics Human Genome Animals Ecosystem Wolves Deer Genome Genomics Alces alces bottlenecks genetic load inbreeding depression purging Biochemistry and Cell Biology |
description |
Island ecosystems provide natural laboratories to assess the impacts of isolation on population persistence. However, most studies of persistence have focused on a single species, without comparisons to other organisms they interact with in the ecosystem. The case study of moose and gray wolves on Isle Royale allows for a direct contrast of genetic variation in isolated populations that have experienced dramatically differing population trajectories over the past decade. Whereas the Isle Royale wolf population recently declined nearly to extinction due to severe inbreeding depression, the moose population has thrived and continues to persist, despite having low genetic diversity and being isolated for ∼120 years. Here, we examine the patterns of genomic variation underlying the continued persistence of the Isle Royale moose population. We document high levels of inbreeding in the population, roughly as high as the wolf population at the time of its decline. However, inbreeding in the moose population manifests in the form of intermediate-length runs of homozygosity suggestive of historical inbreeding and purging, contrasting with the long runs of homozygosity observed in the smaller wolf population. Using simulations, we confirm that substantial purging has likely occurred in the moose population. However, we also document notable increases in genetic load, which could eventually threaten population viability over the long term. Overall, our results demonstrate a complex relationship between inbreeding, genetic diversity, and population viability that highlights the use of genomic datasets and computational simulation tools for understanding the factors enabling persistence in isolated populations. |
author2 |
Nielsen, Rasmus |
format |
Article in Journal/Newspaper |
author |
Kyriazis, Christopher C Beichman, Annabel C Brzeski, Kristin E Hoy, Sarah R Peterson, Rolf O Vucetich, John A Vucetich, Leah M Lohmueller, Kirk E Wayne, Robert K |
author_facet |
Kyriazis, Christopher C Beichman, Annabel C Brzeski, Kristin E Hoy, Sarah R Peterson, Rolf O Vucetich, John A Vucetich, Leah M Lohmueller, Kirk E Wayne, Robert K |
author_sort |
Kyriazis, Christopher C |
title |
Genomic Underpinnings of Population Persistence in Isle Royale Moose |
title_short |
Genomic Underpinnings of Population Persistence in Isle Royale Moose |
title_full |
Genomic Underpinnings of Population Persistence in Isle Royale Moose |
title_fullStr |
Genomic Underpinnings of Population Persistence in Isle Royale Moose |
title_full_unstemmed |
Genomic Underpinnings of Population Persistence in Isle Royale Moose |
title_sort |
genomic underpinnings of population persistence in isle royale moose |
publisher |
eScholarship, University of California |
publishDate |
2023 |
url |
https://escholarship.org/uc/item/8nf6q45n |
op_coverage |
msad021 |
genre |
Alces alces |
genre_facet |
Alces alces |
op_source |
Molecular Biology and Evolution, vol 40, iss 2 |
op_relation |
qt8nf6q45n https://escholarship.org/uc/item/8nf6q45n |
op_rights |
CC-BY |
_version_ |
1782327535446523904 |