Joint effects of cancer and variants in the factor 5 gene on the risk of venous thromboembolism.

• Main Authors: Gran, Olga V, Smith, Erin N, Brækkan, Sigrid K, Jensvoll, Hilde, Solomon, Terry, Hindberg, Kristian, Wilsgaard, Tom, Rosendaal, Frits R, Frazer, Kelly A, Hansen, John-Bjarne
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: eScholarship, University of California 2016
• Subjects: Humans; Neoplasms; Factor V; Population Surveillance; Incidence; Proportional Hazards Models; Risk; Gene Frequency; Genotype; Alleles; Adult; Aged; 80 and over; Middle Aged; Female; Male; Venous Thromboembolism; Genetic Variation; Kaplan-Meier Estimate; Genetics; Clinical Research; Cancer; Prevention; 2.1 Biological and endogenous factors; Aetiology; Cardiorespiratory Medicine and Haematology; Immunology; Meier; Norway; Tromsø
• Online Access: https://escholarship.org/uc/item/8jg2351z

Venous thromboembolism occurs frequently in cancer patients. Two variants in the factor 5 gene (F5), rs6025 encoding for the factor V Leiden mutation R506Q, and rs4524 encoding K858R, have been found to be associated with venous thromboembolism. We assessed the joint effect of active cancer and thes...