Co-regulatory networks of human serum proteins link genetics to disease
Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correl...
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2018
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Online Access: | https://escholarship.org/uc/item/81c6h2dr https://escholarship.org/content/qt81c6h2dr/qt81c6h2dr.pdf https://doi.org/10.1126/science.aaq1327 |
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ftcdlib:oai:escholarship.org:ark:/13030/qt81c6h2dr 2024-10-06T13:50:01+00:00 Co-regulatory networks of human serum proteins link genetics to disease Emilsson, Valur Ilkov, Marjan Lamb, John R Finkel, Nancy Gudmundsson, Elias F Pitts, Rebecca Hoover, Heather Gudmundsdottir, Valborg Horman, Shane R Aspelund, Thor Shu, Le Trifonov, Vladimir Sigurdsson, Sigurdur Manolescu, Andrei Zhu, Jun Olafsson, Örn Jakobsdottir, Johanna Lesley, Scott A To, Jeremy Zhang, Jia Harris, Tamara B Launer, Lenore J Zhang, Bin Eiriksdottir, Gudny Yang, Xia Orth, Anthony P Jennings, Lori L Gudnason, Vilmundur 769 - 773 2018-08-24 application/pdf https://escholarship.org/uc/item/81c6h2dr https://escholarship.org/content/qt81c6h2dr/qt81c6h2dr.pdf https://doi.org/10.1126/science.aaq1327 unknown eScholarship, University of California qt81c6h2dr https://escholarship.org/uc/item/81c6h2dr https://escholarship.org/content/qt81c6h2dr/qt81c6h2dr.pdf doi:10.1126/science.aaq1327 public Science, vol 361, iss 6404 Biochemistry and Cell Biology Biological Sciences Biotechnology Genetics Cardiovascular 2.1 Biological and endogenous factors 1.1 Normal biological development and functioning Generic health relevance Aptamers Nucleotide Blood Proteins Cardiovascular Diseases Genetic Predisposition to Disease Genetic Variation Humans Iceland Metabolic Diseases Metabolic Networks and Pathways Proteome Proteomics General Science & Technology article 2018 ftcdlib https://doi.org/10.1126/science.aaq1327 2024-09-20T00:21:58Z Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correlation between proteins as they varied across individuals revealed 27 different network modules of serum proteins, many of which were associated with cardiovascular and metabolic disease states, as well as overall survival. The protein modules were controlled by cis- and trans-acting genetic variants, which in many cases were also associated with complex disease. This revealed co-regulated groups of circulating proteins that incorporated regulatory control between tissues and demonstrated close relationships to past, current, and future disease states. Article in Journal/Newspaper Iceland University of California: eScholarship Science 361 6404 769 773 |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Biochemistry and Cell Biology Biological Sciences Biotechnology Genetics Cardiovascular 2.1 Biological and endogenous factors 1.1 Normal biological development and functioning Generic health relevance Aptamers Nucleotide Blood Proteins Cardiovascular Diseases Genetic Predisposition to Disease Genetic Variation Humans Iceland Metabolic Diseases Metabolic Networks and Pathways Proteome Proteomics General Science & Technology |
spellingShingle |
Biochemistry and Cell Biology Biological Sciences Biotechnology Genetics Cardiovascular 2.1 Biological and endogenous factors 1.1 Normal biological development and functioning Generic health relevance Aptamers Nucleotide Blood Proteins Cardiovascular Diseases Genetic Predisposition to Disease Genetic Variation Humans Iceland Metabolic Diseases Metabolic Networks and Pathways Proteome Proteomics General Science & Technology Emilsson, Valur Ilkov, Marjan Lamb, John R Finkel, Nancy Gudmundsson, Elias F Pitts, Rebecca Hoover, Heather Gudmundsdottir, Valborg Horman, Shane R Aspelund, Thor Shu, Le Trifonov, Vladimir Sigurdsson, Sigurdur Manolescu, Andrei Zhu, Jun Olafsson, Örn Jakobsdottir, Johanna Lesley, Scott A To, Jeremy Zhang, Jia Harris, Tamara B Launer, Lenore J Zhang, Bin Eiriksdottir, Gudny Yang, Xia Orth, Anthony P Jennings, Lori L Gudnason, Vilmundur Co-regulatory networks of human serum proteins link genetics to disease |
topic_facet |
Biochemistry and Cell Biology Biological Sciences Biotechnology Genetics Cardiovascular 2.1 Biological and endogenous factors 1.1 Normal biological development and functioning Generic health relevance Aptamers Nucleotide Blood Proteins Cardiovascular Diseases Genetic Predisposition to Disease Genetic Variation Humans Iceland Metabolic Diseases Metabolic Networks and Pathways Proteome Proteomics General Science & Technology |
description |
Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correlation between proteins as they varied across individuals revealed 27 different network modules of serum proteins, many of which were associated with cardiovascular and metabolic disease states, as well as overall survival. The protein modules were controlled by cis- and trans-acting genetic variants, which in many cases were also associated with complex disease. This revealed co-regulated groups of circulating proteins that incorporated regulatory control between tissues and demonstrated close relationships to past, current, and future disease states. |
format |
Article in Journal/Newspaper |
author |
Emilsson, Valur Ilkov, Marjan Lamb, John R Finkel, Nancy Gudmundsson, Elias F Pitts, Rebecca Hoover, Heather Gudmundsdottir, Valborg Horman, Shane R Aspelund, Thor Shu, Le Trifonov, Vladimir Sigurdsson, Sigurdur Manolescu, Andrei Zhu, Jun Olafsson, Örn Jakobsdottir, Johanna Lesley, Scott A To, Jeremy Zhang, Jia Harris, Tamara B Launer, Lenore J Zhang, Bin Eiriksdottir, Gudny Yang, Xia Orth, Anthony P Jennings, Lori L Gudnason, Vilmundur |
author_facet |
Emilsson, Valur Ilkov, Marjan Lamb, John R Finkel, Nancy Gudmundsson, Elias F Pitts, Rebecca Hoover, Heather Gudmundsdottir, Valborg Horman, Shane R Aspelund, Thor Shu, Le Trifonov, Vladimir Sigurdsson, Sigurdur Manolescu, Andrei Zhu, Jun Olafsson, Örn Jakobsdottir, Johanna Lesley, Scott A To, Jeremy Zhang, Jia Harris, Tamara B Launer, Lenore J Zhang, Bin Eiriksdottir, Gudny Yang, Xia Orth, Anthony P Jennings, Lori L Gudnason, Vilmundur |
author_sort |
Emilsson, Valur |
title |
Co-regulatory networks of human serum proteins link genetics to disease |
title_short |
Co-regulatory networks of human serum proteins link genetics to disease |
title_full |
Co-regulatory networks of human serum proteins link genetics to disease |
title_fullStr |
Co-regulatory networks of human serum proteins link genetics to disease |
title_full_unstemmed |
Co-regulatory networks of human serum proteins link genetics to disease |
title_sort |
co-regulatory networks of human serum proteins link genetics to disease |
publisher |
eScholarship, University of California |
publishDate |
2018 |
url |
https://escholarship.org/uc/item/81c6h2dr https://escholarship.org/content/qt81c6h2dr/qt81c6h2dr.pdf https://doi.org/10.1126/science.aaq1327 |
op_coverage |
769 - 773 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Science, vol 361, iss 6404 |
op_relation |
qt81c6h2dr https://escholarship.org/uc/item/81c6h2dr https://escholarship.org/content/qt81c6h2dr/qt81c6h2dr.pdf doi:10.1126/science.aaq1327 |
op_rights |
public |
op_doi |
https://doi.org/10.1126/science.aaq1327 |
container_title |
Science |
container_volume |
361 |
container_issue |
6404 |
container_start_page |
769 |
op_container_end_page |
773 |
_version_ |
1812178102408708096 |