Uncovering the genetic history of the present-day Greenlandic population.
Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200...
Published in: | The American Journal of Human Genetics |
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2015
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Online Access: | https://escholarship.org/uc/item/80n7n4ps https://escholarship.org/content/qt80n7n4ps/qt80n7n4ps.pdf https://doi.org/10.1016/j.ajhg.2014.11.012 |
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ftcdlib:oai:escholarship.org:ark:/13030/qt80n7n4ps 2024-09-15T18:04:21+00:00 Uncovering the genetic history of the present-day Greenlandic population. Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn S Crawford, Jacob E Bjerregaard, Peter Jørgensen, Marit E Grarup, Niels Gulløv, Hans Christian Linneberg, Allan Pedersen, Oluf Hansen, Torben Nielsen, Rasmus Albrechtsen, Anders 54 - 69 2015-01-01 application/pdf https://escholarship.org/uc/item/80n7n4ps https://escholarship.org/content/qt80n7n4ps/qt80n7n4ps.pdf https://doi.org/10.1016/j.ajhg.2014.11.012 unknown eScholarship, University of California qt80n7n4ps https://escholarship.org/uc/item/80n7n4ps https://escholarship.org/content/qt80n7n4ps/qt80n7n4ps.pdf doi:10.1016/j.ajhg.2014.11.012 CC-BY-NC-ND American journal of human genetics, vol 96, iss 1 Humans DNA Mitochondrial Evolution Molecular Gene Frequency Genotype Polymorphism Single Nucleotide Genome Human Models Genetic Databases Factual Adult Greenland Female Male Gene Flow Phylogeography Genotyping Techniques Whites White People Genetics Biological Sciences Medical and Health Sciences Genetics & Heredity article 2015 ftcdlib https://doi.org/10.1016/j.ajhg.2014.11.012 2024-06-28T06:28:21Z Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200,000 SNPs from more than 10% of the adult Greenlandic population (n = 4,674). We found that recent gene flow from Europe has had a substantial impact on the population: more than 80% of the Greenlanders have some European ancestry (on average ∼25% of their genome). However, we also found that the amount of recent European gene flow varies across Greenland and is far smaller in the more historically isolated areas in the north and east and in the small villages in the south. Furthermore, we found that there is substantial population structure in the Inuit genetic component of the Greenlanders and that individuals from the east, west, and north can be distinguished from each other. Moreover, the genetic differences in the Inuit ancestry are consistent with a single colonization wave of the island from north to west to south to east. Although it has been speculated that there has been historical admixture between the Norse Vikings who lived in Greenland for a limited period ∼600-1,000 years ago and the Inuit, we found no evidence supporting this hypothesis. Similarly, we found no evidence supporting a previously hypothesized admixture event between the Inuit in East Greenland and the Dorset people, who lived in Greenland before the Inuit. Article in Journal/Newspaper East Greenland Greenland greenlander* greenlandic inuit University of California: eScholarship The American Journal of Human Genetics 96 1 54 69 |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Humans DNA Mitochondrial Evolution Molecular Gene Frequency Genotype Polymorphism Single Nucleotide Genome Human Models Genetic Databases Factual Adult Greenland Female Male Gene Flow Phylogeography Genotyping Techniques Whites White People Genetics Biological Sciences Medical and Health Sciences Genetics & Heredity |
spellingShingle |
Humans DNA Mitochondrial Evolution Molecular Gene Frequency Genotype Polymorphism Single Nucleotide Genome Human Models Genetic Databases Factual Adult Greenland Female Male Gene Flow Phylogeography Genotyping Techniques Whites White People Genetics Biological Sciences Medical and Health Sciences Genetics & Heredity Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn S Crawford, Jacob E Bjerregaard, Peter Jørgensen, Marit E Grarup, Niels Gulløv, Hans Christian Linneberg, Allan Pedersen, Oluf Hansen, Torben Nielsen, Rasmus Albrechtsen, Anders Uncovering the genetic history of the present-day Greenlandic population. |
topic_facet |
Humans DNA Mitochondrial Evolution Molecular Gene Frequency Genotype Polymorphism Single Nucleotide Genome Human Models Genetic Databases Factual Adult Greenland Female Male Gene Flow Phylogeography Genotyping Techniques Whites White People Genetics Biological Sciences Medical and Health Sciences Genetics & Heredity |
description |
Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200,000 SNPs from more than 10% of the adult Greenlandic population (n = 4,674). We found that recent gene flow from Europe has had a substantial impact on the population: more than 80% of the Greenlanders have some European ancestry (on average ∼25% of their genome). However, we also found that the amount of recent European gene flow varies across Greenland and is far smaller in the more historically isolated areas in the north and east and in the small villages in the south. Furthermore, we found that there is substantial population structure in the Inuit genetic component of the Greenlanders and that individuals from the east, west, and north can be distinguished from each other. Moreover, the genetic differences in the Inuit ancestry are consistent with a single colonization wave of the island from north to west to south to east. Although it has been speculated that there has been historical admixture between the Norse Vikings who lived in Greenland for a limited period ∼600-1,000 years ago and the Inuit, we found no evidence supporting this hypothesis. Similarly, we found no evidence supporting a previously hypothesized admixture event between the Inuit in East Greenland and the Dorset people, who lived in Greenland before the Inuit. |
format |
Article in Journal/Newspaper |
author |
Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn S Crawford, Jacob E Bjerregaard, Peter Jørgensen, Marit E Grarup, Niels Gulløv, Hans Christian Linneberg, Allan Pedersen, Oluf Hansen, Torben Nielsen, Rasmus Albrechtsen, Anders |
author_facet |
Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn S Crawford, Jacob E Bjerregaard, Peter Jørgensen, Marit E Grarup, Niels Gulløv, Hans Christian Linneberg, Allan Pedersen, Oluf Hansen, Torben Nielsen, Rasmus Albrechtsen, Anders |
author_sort |
Moltke, Ida |
title |
Uncovering the genetic history of the present-day Greenlandic population. |
title_short |
Uncovering the genetic history of the present-day Greenlandic population. |
title_full |
Uncovering the genetic history of the present-day Greenlandic population. |
title_fullStr |
Uncovering the genetic history of the present-day Greenlandic population. |
title_full_unstemmed |
Uncovering the genetic history of the present-day Greenlandic population. |
title_sort |
uncovering the genetic history of the present-day greenlandic population. |
publisher |
eScholarship, University of California |
publishDate |
2015 |
url |
https://escholarship.org/uc/item/80n7n4ps https://escholarship.org/content/qt80n7n4ps/qt80n7n4ps.pdf https://doi.org/10.1016/j.ajhg.2014.11.012 |
op_coverage |
54 - 69 |
genre |
East Greenland Greenland greenlander* greenlandic inuit |
genre_facet |
East Greenland Greenland greenlander* greenlandic inuit |
op_source |
American journal of human genetics, vol 96, iss 1 |
op_relation |
qt80n7n4ps https://escholarship.org/uc/item/80n7n4ps https://escholarship.org/content/qt80n7n4ps/qt80n7n4ps.pdf doi:10.1016/j.ajhg.2014.11.012 |
op_rights |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.1016/j.ajhg.2014.11.012 |
container_title |
The American Journal of Human Genetics |
container_volume |
96 |
container_issue |
1 |
container_start_page |
54 |
op_container_end_page |
69 |
_version_ |
1810441846781902848 |