Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population.
Background/objectivesSugar intake may be causally associated with chronic disease risk, either directly or by contributing to obesity. However, evidence from observational studies is mixed, in part due to the error and bias inherent in self-reported measures of sugar intake. Objective biomarkers may...
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ftcdlib:oai:escholarship.org:ark:/13030/qt7cm936xp 2023-05-15T15:17:22+02:00 Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population. Nash, SH Kristal, AR Bersamin, A Choy, K Hopkins, SE Stanhope, KL Havel, PJ Boyer, BB O'Brien, DM 91 - 96 2014-01-01 application/pdf https://escholarship.org/uc/item/7cm936xp unknown eScholarship, University of California qt7cm936xp https://escholarship.org/uc/item/7cm936xp public European journal of clinical nutrition, vol 68, iss 1 Humans Obesity Chronic Disease Carbon Isotopes Nitrogen Isotopes Leptin Dietary Carbohydrates Triglycerides Body Mass Index Linear Models Risk Factors Cross-Sectional Studies Blood Pressure Adult Aged 80 and over Middle Aged Indians North American Alaska Female Male Adiponectin Waist Circumference Young Adult Biomarkers carbon nitrogen stable isotope ratio caloric sweeteners Clinical Research Prevention Nutrition Arctic American Indian or Alaska Native Cardiovascular 2.1 Biological and endogenous factors Aetiology Metabolic and endocrine Oral and gastrointestinal Food Sciences Human Movement and Sports Sciences Nutrition and Dietetics Nutrition & Dietetics article 2014 ftcdlib 2022-12-19T18:37:24Z Background/objectivesSugar intake may be causally associated with chronic disease risk, either directly or by contributing to obesity. However, evidence from observational studies is mixed, in part due to the error and bias inherent in self-reported measures of sugar intake. Objective biomarkers may clarify the relationship between sugar intake and chronic disease risk. We have recently validated a biomarker of sugar intake in an Alaska Native (Yup'ik) study population that incorporates red blood cell carbon and nitrogen isotope ratios in a predictive model. This study tested associations of isotopic estimates of sugar intake with body mass index (BMI), waist circumference (WC) and a broad array of other physiological and biochemical measures of chronic disease risk in Yup'ik people.Subjects/methodsIn a cross-sectional sample of 1076 Yup'ik people, multiple linear regression was used to examine associations of sugar intake with BMI, WC and other chronic disease risk factors.ResultsIsotopic estimates of sugar intake were not associated with BMI (P=0.50) or WC (P=0.85). They were positively associated with blood pressure, triglycerides (TG) and leptin, and are inversely associated with total-, high-density lipoprotein- and low-density lipoprotein-cholesterol and adiponectin.ConclusionsIsotopic estimates of sugar intake were not associated with obesity, but were adversely associated with other chronic disease risk factors in this Yup'ik study population. This first use of stable isotope markers of sugar intake may influence recommendations for sugar intake by Yup'ik people; however, longitudinal studies are required to understand associations with chronic disease incidence. Article in Journal/Newspaper Arctic Yup'ik Alaska University of California: eScholarship Arctic Indian |
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Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Humans Obesity Chronic Disease Carbon Isotopes Nitrogen Isotopes Leptin Dietary Carbohydrates Triglycerides Body Mass Index Linear Models Risk Factors Cross-Sectional Studies Blood Pressure Adult Aged 80 and over Middle Aged Indians North American Alaska Female Male Adiponectin Waist Circumference Young Adult Biomarkers carbon nitrogen stable isotope ratio caloric sweeteners Clinical Research Prevention Nutrition Arctic American Indian or Alaska Native Cardiovascular 2.1 Biological and endogenous factors Aetiology Metabolic and endocrine Oral and gastrointestinal Food Sciences Human Movement and Sports Sciences Nutrition and Dietetics Nutrition & Dietetics |
spellingShingle |
Humans Obesity Chronic Disease Carbon Isotopes Nitrogen Isotopes Leptin Dietary Carbohydrates Triglycerides Body Mass Index Linear Models Risk Factors Cross-Sectional Studies Blood Pressure Adult Aged 80 and over Middle Aged Indians North American Alaska Female Male Adiponectin Waist Circumference Young Adult Biomarkers carbon nitrogen stable isotope ratio caloric sweeteners Clinical Research Prevention Nutrition Arctic American Indian or Alaska Native Cardiovascular 2.1 Biological and endogenous factors Aetiology Metabolic and endocrine Oral and gastrointestinal Food Sciences Human Movement and Sports Sciences Nutrition and Dietetics Nutrition & Dietetics Nash, SH Kristal, AR Bersamin, A Choy, K Hopkins, SE Stanhope, KL Havel, PJ Boyer, BB O'Brien, DM Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population. |
topic_facet |
Humans Obesity Chronic Disease Carbon Isotopes Nitrogen Isotopes Leptin Dietary Carbohydrates Triglycerides Body Mass Index Linear Models Risk Factors Cross-Sectional Studies Blood Pressure Adult Aged 80 and over Middle Aged Indians North American Alaska Female Male Adiponectin Waist Circumference Young Adult Biomarkers carbon nitrogen stable isotope ratio caloric sweeteners Clinical Research Prevention Nutrition Arctic American Indian or Alaska Native Cardiovascular 2.1 Biological and endogenous factors Aetiology Metabolic and endocrine Oral and gastrointestinal Food Sciences Human Movement and Sports Sciences Nutrition and Dietetics Nutrition & Dietetics |
description |
Background/objectivesSugar intake may be causally associated with chronic disease risk, either directly or by contributing to obesity. However, evidence from observational studies is mixed, in part due to the error and bias inherent in self-reported measures of sugar intake. Objective biomarkers may clarify the relationship between sugar intake and chronic disease risk. We have recently validated a biomarker of sugar intake in an Alaska Native (Yup'ik) study population that incorporates red blood cell carbon and nitrogen isotope ratios in a predictive model. This study tested associations of isotopic estimates of sugar intake with body mass index (BMI), waist circumference (WC) and a broad array of other physiological and biochemical measures of chronic disease risk in Yup'ik people.Subjects/methodsIn a cross-sectional sample of 1076 Yup'ik people, multiple linear regression was used to examine associations of sugar intake with BMI, WC and other chronic disease risk factors.ResultsIsotopic estimates of sugar intake were not associated with BMI (P=0.50) or WC (P=0.85). They were positively associated with blood pressure, triglycerides (TG) and leptin, and are inversely associated with total-, high-density lipoprotein- and low-density lipoprotein-cholesterol and adiponectin.ConclusionsIsotopic estimates of sugar intake were not associated with obesity, but were adversely associated with other chronic disease risk factors in this Yup'ik study population. This first use of stable isotope markers of sugar intake may influence recommendations for sugar intake by Yup'ik people; however, longitudinal studies are required to understand associations with chronic disease incidence. |
format |
Article in Journal/Newspaper |
author |
Nash, SH Kristal, AR Bersamin, A Choy, K Hopkins, SE Stanhope, KL Havel, PJ Boyer, BB O'Brien, DM |
author_facet |
Nash, SH Kristal, AR Bersamin, A Choy, K Hopkins, SE Stanhope, KL Havel, PJ Boyer, BB O'Brien, DM |
author_sort |
Nash, SH |
title |
Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population. |
title_short |
Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population. |
title_full |
Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population. |
title_fullStr |
Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population. |
title_full_unstemmed |
Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population. |
title_sort |
isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an alaska native (yup'ik) study population. |
publisher |
eScholarship, University of California |
publishDate |
2014 |
url |
https://escholarship.org/uc/item/7cm936xp |
op_coverage |
91 - 96 |
geographic |
Arctic Indian |
geographic_facet |
Arctic Indian |
genre |
Arctic Yup'ik Alaska |
genre_facet |
Arctic Yup'ik Alaska |
op_source |
European journal of clinical nutrition, vol 68, iss 1 |
op_relation |
qt7cm936xp https://escholarship.org/uc/item/7cm936xp |
op_rights |
public |
_version_ |
1766347610082246656 |