Uncovering the genetic history of the present-day Greenlandic population.
Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200...
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ftcdlib:oai:escholarship.org:ark:/13030/qt7ck261fs 2023-10-25T01:38:10+02:00 Uncovering the genetic history of the present-day Greenlandic population. Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn Crawford, Jacob Bjerregaard, Peter Jørgensen, Marit Grarup, Niels Gulløv, Hans Linneberg, Allan Pedersen, Oluf Hansen, Torben Albrechtsen, Anders Nielsen, Rasmus 2015-01-08 application/pdf https://escholarship.org/uc/item/7ck261fs unknown eScholarship, University of California qt7ck261fs https://escholarship.org/uc/item/7ck261fs public American Journal of Human Genetics, vol 96, iss 1 Adult DNA Mitochondrial Databases Factual Evolution Molecular Female Gene Flow Gene Frequency Genome Human Genotype Genotyping Techniques Greenland Humans Male Models Genetic Phylogeography Polymorphism Single Nucleotide White People article 2015 ftcdlib 2023-09-25T18:05:00Z Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200,000 SNPs from more than 10% of the adult Greenlandic population (n = 4,674). We found that recent gene flow from Europe has had a substantial impact on the population: more than 80% of the Greenlanders have some European ancestry (on average ∼25% of their genome). However, we also found that the amount of recent European gene flow varies across Greenland and is far smaller in the more historically isolated areas in the north and east and in the small villages in the south. Furthermore, we found that there is substantial population structure in the Inuit genetic component of the Greenlanders and that individuals from the east, west, and north can be distinguished from each other. Moreover, the genetic differences in the Inuit ancestry are consistent with a single colonization wave of the island from north to west to south to east. Although it has been speculated that there has been historical admixture between the Norse Vikings who lived in Greenland for a limited period ∼600-1,000 years ago and the Inuit, we found no evidence supporting this hypothesis. Similarly, we found no evidence supporting a previously hypothesized admixture event between the Inuit in East Greenland and the Dorset people, who lived in Greenland before the Inuit. Article in Journal/Newspaper East Greenland Greenland greenlander* greenlandic inuit University of California: eScholarship Greenland |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Adult DNA Mitochondrial Databases Factual Evolution Molecular Female Gene Flow Gene Frequency Genome Human Genotype Genotyping Techniques Greenland Humans Male Models Genetic Phylogeography Polymorphism Single Nucleotide White People |
spellingShingle |
Adult DNA Mitochondrial Databases Factual Evolution Molecular Female Gene Flow Gene Frequency Genome Human Genotype Genotyping Techniques Greenland Humans Male Models Genetic Phylogeography Polymorphism Single Nucleotide White People Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn Crawford, Jacob Bjerregaard, Peter Jørgensen, Marit Grarup, Niels Gulløv, Hans Linneberg, Allan Pedersen, Oluf Hansen, Torben Albrechtsen, Anders Nielsen, Rasmus Uncovering the genetic history of the present-day Greenlandic population. |
topic_facet |
Adult DNA Mitochondrial Databases Factual Evolution Molecular Female Gene Flow Gene Frequency Genome Human Genotype Genotyping Techniques Greenland Humans Male Models Genetic Phylogeography Polymorphism Single Nucleotide White People |
description |
Because of past limitations in samples and genotyping technologies, important questions about the history of the present-day Greenlandic population remain unanswered. In an effort to answer these questions and in general investigate the genetic history of the Greenlandic population, we analyzed ∼200,000 SNPs from more than 10% of the adult Greenlandic population (n = 4,674). We found that recent gene flow from Europe has had a substantial impact on the population: more than 80% of the Greenlanders have some European ancestry (on average ∼25% of their genome). However, we also found that the amount of recent European gene flow varies across Greenland and is far smaller in the more historically isolated areas in the north and east and in the small villages in the south. Furthermore, we found that there is substantial population structure in the Inuit genetic component of the Greenlanders and that individuals from the east, west, and north can be distinguished from each other. Moreover, the genetic differences in the Inuit ancestry are consistent with a single colonization wave of the island from north to west to south to east. Although it has been speculated that there has been historical admixture between the Norse Vikings who lived in Greenland for a limited period ∼600-1,000 years ago and the Inuit, we found no evidence supporting this hypothesis. Similarly, we found no evidence supporting a previously hypothesized admixture event between the Inuit in East Greenland and the Dorset people, who lived in Greenland before the Inuit. |
format |
Article in Journal/Newspaper |
author |
Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn Crawford, Jacob Bjerregaard, Peter Jørgensen, Marit Grarup, Niels Gulløv, Hans Linneberg, Allan Pedersen, Oluf Hansen, Torben Albrechtsen, Anders Nielsen, Rasmus |
author_facet |
Moltke, Ida Fumagalli, Matteo Korneliussen, Thorfinn Crawford, Jacob Bjerregaard, Peter Jørgensen, Marit Grarup, Niels Gulløv, Hans Linneberg, Allan Pedersen, Oluf Hansen, Torben Albrechtsen, Anders Nielsen, Rasmus |
author_sort |
Moltke, Ida |
title |
Uncovering the genetic history of the present-day Greenlandic population. |
title_short |
Uncovering the genetic history of the present-day Greenlandic population. |
title_full |
Uncovering the genetic history of the present-day Greenlandic population. |
title_fullStr |
Uncovering the genetic history of the present-day Greenlandic population. |
title_full_unstemmed |
Uncovering the genetic history of the present-day Greenlandic population. |
title_sort |
uncovering the genetic history of the present-day greenlandic population. |
publisher |
eScholarship, University of California |
publishDate |
2015 |
url |
https://escholarship.org/uc/item/7ck261fs |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
East Greenland Greenland greenlander* greenlandic inuit |
genre_facet |
East Greenland Greenland greenlander* greenlandic inuit |
op_source |
American Journal of Human Genetics, vol 96, iss 1 |
op_relation |
qt7ck261fs https://escholarship.org/uc/item/7ck261fs |
op_rights |
public |
_version_ |
1780733145951240192 |