DNA Methylation Patterns Are Associated with n–3 Fatty Acid Intake in Yup’ik People 1–3
A large body of evidence links a high dietary intake of n-3 (ω-3) polyunsaturated fatty acids (PUFAs) with improved cardiometabolic outcomes. Recent studies suggested that the biologic processes underlying the observed associations may involve epigenetic changes, specifically DNA methylation. To eva...
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ftcdlib:oai:escholarship.org:ark:/13030/qt72z2p49k 2023-09-26T15:19:31+02:00 DNA Methylation Patterns Are Associated with n–3 Fatty Acid Intake in Yup’ik People 1–3 Aslibekyan, Stella Wiener, Howard W Havel, Peter J Stanhope, Kimber L O’Brien, Diane M Hopkins, Scarlett E Absher, Devin M Tiwari, Hemant K Boyer, Bert B 425 - 430 2014-04-01 application/pdf https://escholarship.org/uc/item/72z2p49k unknown eScholarship, University of California qt72z2p49k https://escholarship.org/uc/item/72z2p49k public Journal of Nutrition, vol 144, iss 4 Heart Disease Prevention Cardiovascular Genetics Human Genome Nutrition Metabolic and endocrine Adolescent Adult Aged Alaska Aquatic Organisms Biomarkers Cardiovascular Diseases Cross-Sectional Studies DNA Methylation Diabetes Mellitus Diet High-Fat Epigenesis Genetic Erythrocytes Fatty Acids Omega-3 Female Humans Inuit Male Nitrogen Isotopes Risk Factors Animal Production Food Sciences Nutrition and Dietetics Nutrition & Dietetics article 2014 ftcdlib 2023-08-28T18:03:28Z A large body of evidence links a high dietary intake of n-3 (ω-3) polyunsaturated fatty acids (PUFAs) with improved cardiometabolic outcomes. Recent studies suggested that the biologic processes underlying the observed associations may involve epigenetic changes, specifically DNA methylation. To evaluate changes in methylation associated with n-3 PUFA intake, we conducted an epigenome-wide methylation association study of long-chain n-3 PUFA intake and tested associations between the diabetes- and cardiovascular disease-related traits. We assessed DNA methylation at ∼470,000 cytosine-phosphate-guanine (CpG) sites in a cross-sectional study of 185 Yup'ik Alaska Native individuals representing the top and bottom deciles of PUFA intake. Linear regression models were used to test for the associations of interest, adjusting for age, sex, and community group. We identified 27 differentially methylated CpG sites at biologically relevant regions that reached epigenome-wide significance (P < 1 × 10⁻⁷). Specifically, regions on chromosomes 3 (helicase-like transcription factor), 10 (actin α 2 smooth muscle/Fas cell surface death receptor), and 16 (protease serine 36/C16 open reading frame 67) each harbored 2 significant correlates of n-3 PUFA intake. In conclusion, we present promising evidence of association between several biologically relevant epigenetic markers and long-term intake of marine-derived n-3 PUFAs. Article in Journal/Newspaper inuit Yup'ik Alaska University of California: eScholarship |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Heart Disease Prevention Cardiovascular Genetics Human Genome Nutrition Metabolic and endocrine Adolescent Adult Aged Alaska Aquatic Organisms Biomarkers Cardiovascular Diseases Cross-Sectional Studies DNA Methylation Diabetes Mellitus Diet High-Fat Epigenesis Genetic Erythrocytes Fatty Acids Omega-3 Female Humans Inuit Male Nitrogen Isotopes Risk Factors Animal Production Food Sciences Nutrition and Dietetics Nutrition & Dietetics |
spellingShingle |
Heart Disease Prevention Cardiovascular Genetics Human Genome Nutrition Metabolic and endocrine Adolescent Adult Aged Alaska Aquatic Organisms Biomarkers Cardiovascular Diseases Cross-Sectional Studies DNA Methylation Diabetes Mellitus Diet High-Fat Epigenesis Genetic Erythrocytes Fatty Acids Omega-3 Female Humans Inuit Male Nitrogen Isotopes Risk Factors Animal Production Food Sciences Nutrition and Dietetics Nutrition & Dietetics Aslibekyan, Stella Wiener, Howard W Havel, Peter J Stanhope, Kimber L O’Brien, Diane M Hopkins, Scarlett E Absher, Devin M Tiwari, Hemant K Boyer, Bert B DNA Methylation Patterns Are Associated with n–3 Fatty Acid Intake in Yup’ik People 1–3 |
topic_facet |
Heart Disease Prevention Cardiovascular Genetics Human Genome Nutrition Metabolic and endocrine Adolescent Adult Aged Alaska Aquatic Organisms Biomarkers Cardiovascular Diseases Cross-Sectional Studies DNA Methylation Diabetes Mellitus Diet High-Fat Epigenesis Genetic Erythrocytes Fatty Acids Omega-3 Female Humans Inuit Male Nitrogen Isotopes Risk Factors Animal Production Food Sciences Nutrition and Dietetics Nutrition & Dietetics |
description |
A large body of evidence links a high dietary intake of n-3 (ω-3) polyunsaturated fatty acids (PUFAs) with improved cardiometabolic outcomes. Recent studies suggested that the biologic processes underlying the observed associations may involve epigenetic changes, specifically DNA methylation. To evaluate changes in methylation associated with n-3 PUFA intake, we conducted an epigenome-wide methylation association study of long-chain n-3 PUFA intake and tested associations between the diabetes- and cardiovascular disease-related traits. We assessed DNA methylation at ∼470,000 cytosine-phosphate-guanine (CpG) sites in a cross-sectional study of 185 Yup'ik Alaska Native individuals representing the top and bottom deciles of PUFA intake. Linear regression models were used to test for the associations of interest, adjusting for age, sex, and community group. We identified 27 differentially methylated CpG sites at biologically relevant regions that reached epigenome-wide significance (P < 1 × 10⁻⁷). Specifically, regions on chromosomes 3 (helicase-like transcription factor), 10 (actin α 2 smooth muscle/Fas cell surface death receptor), and 16 (protease serine 36/C16 open reading frame 67) each harbored 2 significant correlates of n-3 PUFA intake. In conclusion, we present promising evidence of association between several biologically relevant epigenetic markers and long-term intake of marine-derived n-3 PUFAs. |
format |
Article in Journal/Newspaper |
author |
Aslibekyan, Stella Wiener, Howard W Havel, Peter J Stanhope, Kimber L O’Brien, Diane M Hopkins, Scarlett E Absher, Devin M Tiwari, Hemant K Boyer, Bert B |
author_facet |
Aslibekyan, Stella Wiener, Howard W Havel, Peter J Stanhope, Kimber L O’Brien, Diane M Hopkins, Scarlett E Absher, Devin M Tiwari, Hemant K Boyer, Bert B |
author_sort |
Aslibekyan, Stella |
title |
DNA Methylation Patterns Are Associated with n–3 Fatty Acid Intake in Yup’ik People 1–3 |
title_short |
DNA Methylation Patterns Are Associated with n–3 Fatty Acid Intake in Yup’ik People 1–3 |
title_full |
DNA Methylation Patterns Are Associated with n–3 Fatty Acid Intake in Yup’ik People 1–3 |
title_fullStr |
DNA Methylation Patterns Are Associated with n–3 Fatty Acid Intake in Yup’ik People 1–3 |
title_full_unstemmed |
DNA Methylation Patterns Are Associated with n–3 Fatty Acid Intake in Yup’ik People 1–3 |
title_sort |
dna methylation patterns are associated with n–3 fatty acid intake in yup’ik people 1–3 |
publisher |
eScholarship, University of California |
publishDate |
2014 |
url |
https://escholarship.org/uc/item/72z2p49k |
op_coverage |
425 - 430 |
genre |
inuit Yup'ik Alaska |
genre_facet |
inuit Yup'ik Alaska |
op_source |
Journal of Nutrition, vol 144, iss 4 |
op_relation |
qt72z2p49k https://escholarship.org/uc/item/72z2p49k |
op_rights |
public |
_version_ |
1778142874188120064 |