Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women
ContextOsteocyte activity is crucial to the maintenance of bone quality. Sclerostin, an osteocyte product, inhibits bone formation, yet higher circulating sclerostin is associated with higher bone density. Bone marrow fat (MF) is associated with osteoporosis, but little is known about the relationsh...
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ftcdlib:oai:escholarship.org:ark:/13030/qt72s732r2 2023-10-25T01:39:53+02:00 Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women Vivian, Yu-Heng Schwartz, Ann V Sigurdsson, Sigurdur Hue, Trisha F Lang, Thomas F Harris, Tamara B Rosen, Clifford J Vittinghoff, Eric Eiriksdottir, Gudny Hauksdottir, Alda M Siggeirsdottir, Kristin Sigurdsson, Gunnar Oskarsdottir, Diana Napoli, Nicola Palermo, Lisa Gudnason, Vilmundur Li, Xiaojuan e2584 - e2590 2014-12-01 https://escholarship.org/uc/item/72s732r2 unknown eScholarship, University of California qt72s732r2 https://escholarship.org/uc/item/72s732r2 public The Journal of Clinical Endocrinology & Metabolism, vol 99, iss 12 Biomedical and Clinical Sciences Clinical Sciences Nutrition Aging Prevention Obesity Osteoporosis Clinical Research Musculoskeletal Absorptiometry Photon Adaptor Proteins Signal Transducing Adipose Tissue Aged 80 and over Biomarkers Bone Density Bone Marrow Bone Morphogenetic Proteins Cohort Studies Cross-Sectional Studies Female Genetic Markers Humans Iceland Male Osteocytes Sex Characteristics Tomography X-Ray Computed Paediatrics and Reproductive Medicine Endocrinology & Metabolism article 2014 ftcdlib 2023-09-25T18:03:28Z ContextOsteocyte activity is crucial to the maintenance of bone quality. Sclerostin, an osteocyte product, inhibits bone formation, yet higher circulating sclerostin is associated with higher bone density. Bone marrow fat (MF) is associated with osteoporosis, but little is known about the relationship between osteocyte activity and MF.ObjectiveOur objective was to assess the relationships between circulating sclerostin, vertebral MF, volumetric bone mineral density (vBMD), and other fat depots in older adults.Design, setting, and participantsWe conducted a cross-sectional study in the Age Gene/Environment Susceptibility-Reykjavik cohort.Main outcome measuresOutcome measures included vertebral MF (L1-L4) measured with magnetic resonance spectroscopy and vBMD (spine and hip) and abdominal fat measured with quantitative computed tomography.ResultsAfter excluding subjects with bone-active medication use (n = 50), inadequate serum (n = 2), or inadequate magnetic resonance spectroscopy (n = 1), analyses included 115 men and 134 women (mean age 79 y, mean body mass index 27.7 kg/m(2)). In men, but not women, vertebral MF was greater in those with higher serum sclerostin levels. MF was 52.2 % in the lowest tertile of serum sclerostin and 56.3% in the highest tertile in men (P for trend <.01) in models adjusted for age, body mass index, and diabetes. Sclerostin was positively associated with cortical and trabecular total hip vBMD, weight in men and women, and total fat mass in men but was not associated with total lean mass or abdominal fat depots.ConclusionCirculating sclerostin levels are associated with higher vertebral marrow fat in men, suggesting a relationship between osteocyte function and marrow adipogenesis. Article in Journal/Newspaper Iceland University of California: eScholarship |
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Open Polar |
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University of California: eScholarship |
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unknown |
topic |
Biomedical and Clinical Sciences Clinical Sciences Nutrition Aging Prevention Obesity Osteoporosis Clinical Research Musculoskeletal Absorptiometry Photon Adaptor Proteins Signal Transducing Adipose Tissue Aged 80 and over Biomarkers Bone Density Bone Marrow Bone Morphogenetic Proteins Cohort Studies Cross-Sectional Studies Female Genetic Markers Humans Iceland Male Osteocytes Sex Characteristics Tomography X-Ray Computed Paediatrics and Reproductive Medicine Endocrinology & Metabolism |
spellingShingle |
Biomedical and Clinical Sciences Clinical Sciences Nutrition Aging Prevention Obesity Osteoporosis Clinical Research Musculoskeletal Absorptiometry Photon Adaptor Proteins Signal Transducing Adipose Tissue Aged 80 and over Biomarkers Bone Density Bone Marrow Bone Morphogenetic Proteins Cohort Studies Cross-Sectional Studies Female Genetic Markers Humans Iceland Male Osteocytes Sex Characteristics Tomography X-Ray Computed Paediatrics and Reproductive Medicine Endocrinology & Metabolism Vivian, Yu-Heng Schwartz, Ann V Sigurdsson, Sigurdur Hue, Trisha F Lang, Thomas F Harris, Tamara B Rosen, Clifford J Vittinghoff, Eric Eiriksdottir, Gudny Hauksdottir, Alda M Siggeirsdottir, Kristin Sigurdsson, Gunnar Oskarsdottir, Diana Napoli, Nicola Palermo, Lisa Gudnason, Vilmundur Li, Xiaojuan Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women |
topic_facet |
Biomedical and Clinical Sciences Clinical Sciences Nutrition Aging Prevention Obesity Osteoporosis Clinical Research Musculoskeletal Absorptiometry Photon Adaptor Proteins Signal Transducing Adipose Tissue Aged 80 and over Biomarkers Bone Density Bone Marrow Bone Morphogenetic Proteins Cohort Studies Cross-Sectional Studies Female Genetic Markers Humans Iceland Male Osteocytes Sex Characteristics Tomography X-Ray Computed Paediatrics and Reproductive Medicine Endocrinology & Metabolism |
description |
ContextOsteocyte activity is crucial to the maintenance of bone quality. Sclerostin, an osteocyte product, inhibits bone formation, yet higher circulating sclerostin is associated with higher bone density. Bone marrow fat (MF) is associated with osteoporosis, but little is known about the relationship between osteocyte activity and MF.ObjectiveOur objective was to assess the relationships between circulating sclerostin, vertebral MF, volumetric bone mineral density (vBMD), and other fat depots in older adults.Design, setting, and participantsWe conducted a cross-sectional study in the Age Gene/Environment Susceptibility-Reykjavik cohort.Main outcome measuresOutcome measures included vertebral MF (L1-L4) measured with magnetic resonance spectroscopy and vBMD (spine and hip) and abdominal fat measured with quantitative computed tomography.ResultsAfter excluding subjects with bone-active medication use (n = 50), inadequate serum (n = 2), or inadequate magnetic resonance spectroscopy (n = 1), analyses included 115 men and 134 women (mean age 79 y, mean body mass index 27.7 kg/m(2)). In men, but not women, vertebral MF was greater in those with higher serum sclerostin levels. MF was 52.2 % in the lowest tertile of serum sclerostin and 56.3% in the highest tertile in men (P for trend <.01) in models adjusted for age, body mass index, and diabetes. Sclerostin was positively associated with cortical and trabecular total hip vBMD, weight in men and women, and total fat mass in men but was not associated with total lean mass or abdominal fat depots.ConclusionCirculating sclerostin levels are associated with higher vertebral marrow fat in men, suggesting a relationship between osteocyte function and marrow adipogenesis. |
format |
Article in Journal/Newspaper |
author |
Vivian, Yu-Heng Schwartz, Ann V Sigurdsson, Sigurdur Hue, Trisha F Lang, Thomas F Harris, Tamara B Rosen, Clifford J Vittinghoff, Eric Eiriksdottir, Gudny Hauksdottir, Alda M Siggeirsdottir, Kristin Sigurdsson, Gunnar Oskarsdottir, Diana Napoli, Nicola Palermo, Lisa Gudnason, Vilmundur Li, Xiaojuan |
author_facet |
Vivian, Yu-Heng Schwartz, Ann V Sigurdsson, Sigurdur Hue, Trisha F Lang, Thomas F Harris, Tamara B Rosen, Clifford J Vittinghoff, Eric Eiriksdottir, Gudny Hauksdottir, Alda M Siggeirsdottir, Kristin Sigurdsson, Gunnar Oskarsdottir, Diana Napoli, Nicola Palermo, Lisa Gudnason, Vilmundur Li, Xiaojuan |
author_sort |
Vivian, Yu-Heng |
title |
Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women |
title_short |
Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women |
title_full |
Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women |
title_fullStr |
Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women |
title_full_unstemmed |
Circulating Sclerostin Associated With Vertebral Bone Marrow Fat in Older Men But Not Women |
title_sort |
circulating sclerostin associated with vertebral bone marrow fat in older men but not women |
publisher |
eScholarship, University of California |
publishDate |
2014 |
url |
https://escholarship.org/uc/item/72s732r2 |
op_coverage |
e2584 - e2590 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
The Journal of Clinical Endocrinology & Metabolism, vol 99, iss 12 |
op_relation |
qt72s732r2 https://escholarship.org/uc/item/72s732r2 |
op_rights |
public |
_version_ |
1780735476260405248 |