Towards Genomics-Informed Biodiversity Conservation: Case Studies on Environmental DNA, Fin Whales and Bobcats Genomics and the Distribution of Fitness Effects
Global biodiversity is declining at an alarming rate. Genetics approaches have been invaluable for conservation practices across scales, from identifying impacts of inbreeding in endangered species to mapping global biodiversity patterns. The rapid development of next-generation sequencing technolog...
Main Author: | |
---|---|
Other Authors: | , |
Format: | Thesis |
Language: | English |
Published: |
eScholarship, University of California
2022
|
Subjects: | |
Online Access: | https://escholarship.org/uc/item/6nr8p2d8 |
id |
ftcdlib:oai:escholarship.org:ark:/13030/qt6nr8p2d8 |
---|---|
record_format |
openpolar |
spelling |
ftcdlib:oai:escholarship.org:ark:/13030/qt6nr8p2d8 2024-06-23T07:51:33+00:00 Towards Genomics-Informed Biodiversity Conservation: Case Studies on Environmental DNA, Fin Whales and Bobcats Genomics and the Distribution of Fitness Effects Lin, Meixi Lohmueller, Kirk Edward Wayne, Robert 2022-01-01 application/pdf https://escholarship.org/uc/item/6nr8p2d8 en eng eScholarship, University of California qt6nr8p2d8 https://escholarship.org/uc/item/6nr8p2d8 public Genetics Ecology Conservation biology Community ecology Deleterious variation Fisher’s geometric model Genome assembly Molecular ecology Population genetics etd 2022 ftcdlib 2024-06-05T00:31:59Z Global biodiversity is declining at an alarming rate. Genetics approaches have been invaluable for conservation practices across scales, from identifying impacts of inbreeding in endangered species to mapping global biodiversity patterns. The rapid development of next-generation sequencing technologies and computational advances further enabled genomics-informed biodiversity conservation in the 21st century. Compared with a handful of genetic markers that could only be acquired in relatively high-quality genetic materials, genomics approaches generate data with whole genome coverage and allow analyses on environmental DNA (eDNA). Here I demonstrate the applications of genomics in biodiversity conservation in four case studies that encompass a wide spectrum of genetic material types, from eDNA to whole genome sequencing, and a wide spectrum of topics, from population genetics to landscape ecology. In the first chapter, I analyzed the landscape biodiversity pattern derived from eDNA metabarcoding using surface soil samples collected across California. Combining eDNA with environmental predictors, including remote sensing data, have capacity to model biodiversity at landscape scales and to create new biodiversity baselines that span the tree of life. In the second chapter, I analyzed the population genomics pattern in a pair of fin whale (Balaenoptera physalus) populations with contrasting demographic trajectories and whaling pressures. I was able to detect the severity of whaling in the Eastern North Pacific population and found that even low levels of migration are crucial to the sustenance of the small and isolated Gulf of California population. In the third chapter, I extended the single-species population genomics to a comparative framework and evaluated the extent of the Distribution of Fitness Effects variation in eight animal species with diverse phylogenetic relationships. I found that the DFE is more similar in more closely related species. In the appendix chapter, I provided another example of how ... Thesis Balaenoptera physalus Fin whale University of California: eScholarship Pacific |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
English |
topic |
Genetics Ecology Conservation biology Community ecology Deleterious variation Fisher’s geometric model Genome assembly Molecular ecology Population genetics |
spellingShingle |
Genetics Ecology Conservation biology Community ecology Deleterious variation Fisher’s geometric model Genome assembly Molecular ecology Population genetics Lin, Meixi Towards Genomics-Informed Biodiversity Conservation: Case Studies on Environmental DNA, Fin Whales and Bobcats Genomics and the Distribution of Fitness Effects |
topic_facet |
Genetics Ecology Conservation biology Community ecology Deleterious variation Fisher’s geometric model Genome assembly Molecular ecology Population genetics |
description |
Global biodiversity is declining at an alarming rate. Genetics approaches have been invaluable for conservation practices across scales, from identifying impacts of inbreeding in endangered species to mapping global biodiversity patterns. The rapid development of next-generation sequencing technologies and computational advances further enabled genomics-informed biodiversity conservation in the 21st century. Compared with a handful of genetic markers that could only be acquired in relatively high-quality genetic materials, genomics approaches generate data with whole genome coverage and allow analyses on environmental DNA (eDNA). Here I demonstrate the applications of genomics in biodiversity conservation in four case studies that encompass a wide spectrum of genetic material types, from eDNA to whole genome sequencing, and a wide spectrum of topics, from population genetics to landscape ecology. In the first chapter, I analyzed the landscape biodiversity pattern derived from eDNA metabarcoding using surface soil samples collected across California. Combining eDNA with environmental predictors, including remote sensing data, have capacity to model biodiversity at landscape scales and to create new biodiversity baselines that span the tree of life. In the second chapter, I analyzed the population genomics pattern in a pair of fin whale (Balaenoptera physalus) populations with contrasting demographic trajectories and whaling pressures. I was able to detect the severity of whaling in the Eastern North Pacific population and found that even low levels of migration are crucial to the sustenance of the small and isolated Gulf of California population. In the third chapter, I extended the single-species population genomics to a comparative framework and evaluated the extent of the Distribution of Fitness Effects variation in eight animal species with diverse phylogenetic relationships. I found that the DFE is more similar in more closely related species. In the appendix chapter, I provided another example of how ... |
author2 |
Lohmueller, Kirk Edward Wayne, Robert |
format |
Thesis |
author |
Lin, Meixi |
author_facet |
Lin, Meixi |
author_sort |
Lin, Meixi |
title |
Towards Genomics-Informed Biodiversity Conservation: Case Studies on Environmental DNA, Fin Whales and Bobcats Genomics and the Distribution of Fitness Effects |
title_short |
Towards Genomics-Informed Biodiversity Conservation: Case Studies on Environmental DNA, Fin Whales and Bobcats Genomics and the Distribution of Fitness Effects |
title_full |
Towards Genomics-Informed Biodiversity Conservation: Case Studies on Environmental DNA, Fin Whales and Bobcats Genomics and the Distribution of Fitness Effects |
title_fullStr |
Towards Genomics-Informed Biodiversity Conservation: Case Studies on Environmental DNA, Fin Whales and Bobcats Genomics and the Distribution of Fitness Effects |
title_full_unstemmed |
Towards Genomics-Informed Biodiversity Conservation: Case Studies on Environmental DNA, Fin Whales and Bobcats Genomics and the Distribution of Fitness Effects |
title_sort |
towards genomics-informed biodiversity conservation: case studies on environmental dna, fin whales and bobcats genomics and the distribution of fitness effects |
publisher |
eScholarship, University of California |
publishDate |
2022 |
url |
https://escholarship.org/uc/item/6nr8p2d8 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Balaenoptera physalus Fin whale |
genre_facet |
Balaenoptera physalus Fin whale |
op_relation |
qt6nr8p2d8 https://escholarship.org/uc/item/6nr8p2d8 |
op_rights |
public |
_version_ |
1802642672312123392 |