Total Synthesis of Cadlinolide A and Efforts Towards the Synthesis of Darwinolide
Natural products have always been a classic source of new treatments against diseases. Recently, the Darwinellidae family of Antarctic sea sponges have yielded a family of molecules with high potency against diseases with poor or no current treatment.1 Darwinolide has been shown to penetrate MRSA ba...
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2022
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ftcdlib:oai:escholarship.org:ark:/13030/qt67z0t3t0 2023-09-05T13:14:20+02:00 Total Synthesis of Cadlinolide A and Efforts Towards the Synthesis of Darwinolide Levin, Jacob Elliot Zakarian, Armen 2022-01-01 application/pdf https://escholarship.org/uc/item/67z0t3t0 en eng eScholarship, University of California qt67z0t3t0 https://escholarship.org/uc/item/67z0t3t0 public Organic chemistry Divergent Synthesis Total Synthesis etd 2022 ftcdlib 2023-08-21T18:05:46Z Natural products have always been a classic source of new treatments against diseases. Recently, the Darwinellidae family of Antarctic sea sponges have yielded a family of molecules with high potency against diseases with poor or no current treatment.1 Darwinolide has been shown to penetrate MRSA bacterial biofilms, while the six-membered ring variants have been shown to be active against Leishmaniasis and Malaria.1 These compounds can revolutionize treatments, but are difficult to make individually. A single, robust pathway toward the entire family will allow for the synthesis of related structures that can be tested for similar disease efficacy. The synthetic efforts described in this thesis will enable rapid construction of the common core structure and subsequent access to all family members as well as bioactive analogues. Thesis Antarc* Antarctic University of California: eScholarship Antarctic |
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Open Polar |
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University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
English |
topic |
Organic chemistry Divergent Synthesis Total Synthesis |
spellingShingle |
Organic chemistry Divergent Synthesis Total Synthesis Levin, Jacob Elliot Total Synthesis of Cadlinolide A and Efforts Towards the Synthesis of Darwinolide |
topic_facet |
Organic chemistry Divergent Synthesis Total Synthesis |
description |
Natural products have always been a classic source of new treatments against diseases. Recently, the Darwinellidae family of Antarctic sea sponges have yielded a family of molecules with high potency against diseases with poor or no current treatment.1 Darwinolide has been shown to penetrate MRSA bacterial biofilms, while the six-membered ring variants have been shown to be active against Leishmaniasis and Malaria.1 These compounds can revolutionize treatments, but are difficult to make individually. A single, robust pathway toward the entire family will allow for the synthesis of related structures that can be tested for similar disease efficacy. The synthetic efforts described in this thesis will enable rapid construction of the common core structure and subsequent access to all family members as well as bioactive analogues. |
author2 |
Zakarian, Armen |
format |
Thesis |
author |
Levin, Jacob Elliot |
author_facet |
Levin, Jacob Elliot |
author_sort |
Levin, Jacob Elliot |
title |
Total Synthesis of Cadlinolide A and Efforts Towards the Synthesis of Darwinolide |
title_short |
Total Synthesis of Cadlinolide A and Efforts Towards the Synthesis of Darwinolide |
title_full |
Total Synthesis of Cadlinolide A and Efforts Towards the Synthesis of Darwinolide |
title_fullStr |
Total Synthesis of Cadlinolide A and Efforts Towards the Synthesis of Darwinolide |
title_full_unstemmed |
Total Synthesis of Cadlinolide A and Efforts Towards the Synthesis of Darwinolide |
title_sort |
total synthesis of cadlinolide a and efforts towards the synthesis of darwinolide |
publisher |
eScholarship, University of California |
publishDate |
2022 |
url |
https://escholarship.org/uc/item/67z0t3t0 |
geographic |
Antarctic |
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Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
qt67z0t3t0 https://escholarship.org/uc/item/67z0t3t0 |
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public |
_version_ |
1776205327426912256 |