Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs
BackgroundHeritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown.ObjectiveInvestigate the heritability and mode of inheritance of DM in AED.AnimalsAn extended family of AED including 71 AED without DM, 47 AED with an unknown phenotype, an...
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ftcdlib:oai:escholarship.org:ark:/13030/qt5625z7rw 2023-11-05T03:41:46+01:00 Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs Cai, Stephen V Famula, Thomas R Oberbauer, Anita M Hess, Rebecka S 1926 - 1934 2019-09-01 application/pdf https://escholarship.org/uc/item/5625z7rw unknown eScholarship, University of California qt5625z7rw https://escholarship.org/uc/item/5625z7rw public Journal of Veterinary Internal Medicine, vol 33, iss 5 Veterinary Sciences Agricultural Veterinary and Food Sciences Diabetes Animals Diabetes Mellitus Dog Diseases Dogs Female Genetic Predisposition to Disease Male Orchiectomy Ovariectomy Pedigree Retrospective Studies canine genetic risk non-Mendelian polygenic article 2019 ftcdlib 2023-10-09T18:07:03Z BackgroundHeritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown.ObjectiveInvestigate the heritability and mode of inheritance of DM in AED.AnimalsAn extended family of AED including 71 AED without DM, 47 AED with an unknown phenotype, and 38 AED with spontaneous DM.MethodsRetrospective evaluation of inheritance. A logistic regression model was formulated to evaluate the heritability of DM, including effects of sex and neuter status. Subsequently, complex segregation analysis was employed to investigate the inheritance pattern of DM in AED. Six plausible models were considered, and the Akaike Information Criterion was used to determine the best of the biologically feasible models of inheritance of DM in AED.ResultsHeritability of DM in AED is estimated at 0.62 (95% posterior interval 0.01-0.99). Predicted DM probabilities for neutered females (NF), intact females (IF), neutered males (NM), and intact males (IM) were 0.76, 0.11, 0.63, and 0.12, respectively. There was no overlap between the 95% posterior intervals of disease probabilities in NF and IF or in NF and IM. Complex segregation analysis suggested that the mode of inheritance of DM in AED is polygenic, with no evidence for a single gene of large effect.Conclusions and clinical importanceThe estimated heritability of DM in AED is high but has low precision. Diabetes mellitus transmission in AED appears to follow a polygenic inheritance. Breeders could successfully implement a breeding program to decrease the incidence of DM in AED. Article in Journal/Newspaper eskimo* University of California: eScholarship |
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Open Polar |
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University of California: eScholarship |
op_collection_id |
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language |
unknown |
topic |
Veterinary Sciences Agricultural Veterinary and Food Sciences Diabetes Animals Diabetes Mellitus Dog Diseases Dogs Female Genetic Predisposition to Disease Male Orchiectomy Ovariectomy Pedigree Retrospective Studies canine genetic risk non-Mendelian polygenic |
spellingShingle |
Veterinary Sciences Agricultural Veterinary and Food Sciences Diabetes Animals Diabetes Mellitus Dog Diseases Dogs Female Genetic Predisposition to Disease Male Orchiectomy Ovariectomy Pedigree Retrospective Studies canine genetic risk non-Mendelian polygenic Cai, Stephen V Famula, Thomas R Oberbauer, Anita M Hess, Rebecka S Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
topic_facet |
Veterinary Sciences Agricultural Veterinary and Food Sciences Diabetes Animals Diabetes Mellitus Dog Diseases Dogs Female Genetic Predisposition to Disease Male Orchiectomy Ovariectomy Pedigree Retrospective Studies canine genetic risk non-Mendelian polygenic |
description |
BackgroundHeritability and mode of inheritance of spontaneous diabetes mellitus (DM) in American Eskimo Dogs (AED) are unknown.ObjectiveInvestigate the heritability and mode of inheritance of DM in AED.AnimalsAn extended family of AED including 71 AED without DM, 47 AED with an unknown phenotype, and 38 AED with spontaneous DM.MethodsRetrospective evaluation of inheritance. A logistic regression model was formulated to evaluate the heritability of DM, including effects of sex and neuter status. Subsequently, complex segregation analysis was employed to investigate the inheritance pattern of DM in AED. Six plausible models were considered, and the Akaike Information Criterion was used to determine the best of the biologically feasible models of inheritance of DM in AED.ResultsHeritability of DM in AED is estimated at 0.62 (95% posterior interval 0.01-0.99). Predicted DM probabilities for neutered females (NF), intact females (IF), neutered males (NM), and intact males (IM) were 0.76, 0.11, 0.63, and 0.12, respectively. There was no overlap between the 95% posterior intervals of disease probabilities in NF and IF or in NF and IM. Complex segregation analysis suggested that the mode of inheritance of DM in AED is polygenic, with no evidence for a single gene of large effect.Conclusions and clinical importanceThe estimated heritability of DM in AED is high but has low precision. Diabetes mellitus transmission in AED appears to follow a polygenic inheritance. Breeders could successfully implement a breeding program to decrease the incidence of DM in AED. |
format |
Article in Journal/Newspaper |
author |
Cai, Stephen V Famula, Thomas R Oberbauer, Anita M Hess, Rebecka S |
author_facet |
Cai, Stephen V Famula, Thomas R Oberbauer, Anita M Hess, Rebecka S |
author_sort |
Cai, Stephen V |
title |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_short |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_full |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_fullStr |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_full_unstemmed |
Heritability and complex segregation analysis of diabetes mellitus in American Eskimo Dogs |
title_sort |
heritability and complex segregation analysis of diabetes mellitus in american eskimo dogs |
publisher |
eScholarship, University of California |
publishDate |
2019 |
url |
https://escholarship.org/uc/item/5625z7rw |
op_coverage |
1926 - 1934 |
genre |
eskimo* |
genre_facet |
eskimo* |
op_source |
Journal of Veterinary Internal Medicine, vol 33, iss 5 |
op_relation |
qt5625z7rw https://escholarship.org/uc/item/5625z7rw |
op_rights |
public |
_version_ |
1781698396253323264 |