Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos.
Variants of carnitine palmitoyltransferase 1A (CPT1A), a key hepatic lipid oxidation enzyme, may influence how fatty acid oxidation contributes to obesity and metabolic outcomes. CPT1A is regulated by diet, suggesting interactions between gene variants and diet may influence outcomes. The objective...
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ftcdlib:oai:escholarship.org:ark:/13030/qt4gt701w8 2023-05-15T16:06:40+02:00 Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. Lemas, Dominick J Wiener, Howard W O'Brien, Diane M Hopkins, Scarlett Stanhope, Kimber L Havel, Peter J Allison, David B Fernandez, Jose R Tiwari, Hemant K Boyer, Bert B 175 - 184 2012-01-01 application/pdf https://escholarship.org/uc/item/4gt701w8 unknown eScholarship, University of California qt4gt701w8 https://escholarship.org/uc/item/4gt701w8 public Journal of lipid research, vol 53, iss 1 Humans Obesity Carnitine O-Palmitoyltransferase Fatty Acids Omega-3 Body Composition Polymorphism Single Nucleotide Adolescent Adult Aged 80 and over Middle Aged Inuits Cholesterol HDL lipids lipids/oxidation mitochondria omega-3 fatty acids Alaska Native healthy obesity Genetics Digestive Diseases Nutrition Aetiology 2.1 Biological and endogenous factors Oral and gastrointestinal Stroke Metabolic and endocrine Cancer Cardiovascular Biochemistry and Cell Biology Medical Biochemistry and Metabolomics Biochemistry & Molecular Biology article 2012 ftcdlib 2022-12-19T18:37:24Z Variants of carnitine palmitoyltransferase 1A (CPT1A), a key hepatic lipid oxidation enzyme, may influence how fatty acid oxidation contributes to obesity and metabolic outcomes. CPT1A is regulated by diet, suggesting interactions between gene variants and diet may influence outcomes. The objective of this study was to test the association of CPT1A variants with body composition and lipids, mediated by consumption of polyunsaturated fatty acids (PUFA). Obesity phenotypes and fasting lipids were measured in a cross-sectional sample of Yup'ik Eskimo individuals (n = 1141) from the Center of Alaska Native Health Research (CANHR) study. Twenty-eight tagging CPT1A SNPs were evaluated with outcomes of interest in regression models accounting for family structure. Several CPT1A polymorphisms were associated with HDL-cholesterol and obesity phenotypes. The P479L (rs80356779) variant was associated with all obesity-related traits and fasting HDL-cholesterol. Interestingly, the association of P479L with HDL-cholesterol was still significant after correcting for body mass index (BMI), percentage body fat (PBF), or waist circumference (WC). Our findings are consistent with the hypothesis that the L479 allele of the CPT1A P479L variant confers a selective advantage that is both cardioprotective (through increased HDL-cholesterol) and associated with reduced adiposity. Article in Journal/Newspaper eskimo* inuits Yup'ik Alaska University of California: eScholarship |
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Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
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language |
unknown |
topic |
Humans Obesity Carnitine O-Palmitoyltransferase Fatty Acids Omega-3 Body Composition Polymorphism Single Nucleotide Adolescent Adult Aged 80 and over Middle Aged Inuits Cholesterol HDL lipids lipids/oxidation mitochondria omega-3 fatty acids Alaska Native healthy obesity Genetics Digestive Diseases Nutrition Aetiology 2.1 Biological and endogenous factors Oral and gastrointestinal Stroke Metabolic and endocrine Cancer Cardiovascular Biochemistry and Cell Biology Medical Biochemistry and Metabolomics Biochemistry & Molecular Biology |
spellingShingle |
Humans Obesity Carnitine O-Palmitoyltransferase Fatty Acids Omega-3 Body Composition Polymorphism Single Nucleotide Adolescent Adult Aged 80 and over Middle Aged Inuits Cholesterol HDL lipids lipids/oxidation mitochondria omega-3 fatty acids Alaska Native healthy obesity Genetics Digestive Diseases Nutrition Aetiology 2.1 Biological and endogenous factors Oral and gastrointestinal Stroke Metabolic and endocrine Cancer Cardiovascular Biochemistry and Cell Biology Medical Biochemistry and Metabolomics Biochemistry & Molecular Biology Lemas, Dominick J Wiener, Howard W O'Brien, Diane M Hopkins, Scarlett Stanhope, Kimber L Havel, Peter J Allison, David B Fernandez, Jose R Tiwari, Hemant K Boyer, Bert B Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. |
topic_facet |
Humans Obesity Carnitine O-Palmitoyltransferase Fatty Acids Omega-3 Body Composition Polymorphism Single Nucleotide Adolescent Adult Aged 80 and over Middle Aged Inuits Cholesterol HDL lipids lipids/oxidation mitochondria omega-3 fatty acids Alaska Native healthy obesity Genetics Digestive Diseases Nutrition Aetiology 2.1 Biological and endogenous factors Oral and gastrointestinal Stroke Metabolic and endocrine Cancer Cardiovascular Biochemistry and Cell Biology Medical Biochemistry and Metabolomics Biochemistry & Molecular Biology |
description |
Variants of carnitine palmitoyltransferase 1A (CPT1A), a key hepatic lipid oxidation enzyme, may influence how fatty acid oxidation contributes to obesity and metabolic outcomes. CPT1A is regulated by diet, suggesting interactions between gene variants and diet may influence outcomes. The objective of this study was to test the association of CPT1A variants with body composition and lipids, mediated by consumption of polyunsaturated fatty acids (PUFA). Obesity phenotypes and fasting lipids were measured in a cross-sectional sample of Yup'ik Eskimo individuals (n = 1141) from the Center of Alaska Native Health Research (CANHR) study. Twenty-eight tagging CPT1A SNPs were evaluated with outcomes of interest in regression models accounting for family structure. Several CPT1A polymorphisms were associated with HDL-cholesterol and obesity phenotypes. The P479L (rs80356779) variant was associated with all obesity-related traits and fasting HDL-cholesterol. Interestingly, the association of P479L with HDL-cholesterol was still significant after correcting for body mass index (BMI), percentage body fat (PBF), or waist circumference (WC). Our findings are consistent with the hypothesis that the L479 allele of the CPT1A P479L variant confers a selective advantage that is both cardioprotective (through increased HDL-cholesterol) and associated with reduced adiposity. |
format |
Article in Journal/Newspaper |
author |
Lemas, Dominick J Wiener, Howard W O'Brien, Diane M Hopkins, Scarlett Stanhope, Kimber L Havel, Peter J Allison, David B Fernandez, Jose R Tiwari, Hemant K Boyer, Bert B |
author_facet |
Lemas, Dominick J Wiener, Howard W O'Brien, Diane M Hopkins, Scarlett Stanhope, Kimber L Havel, Peter J Allison, David B Fernandez, Jose R Tiwari, Hemant K Boyer, Bert B |
author_sort |
Lemas, Dominick J |
title |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. |
title_short |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. |
title_full |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. |
title_fullStr |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. |
title_full_unstemmed |
Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. |
title_sort |
genetic polymorphisms in carnitine palmitoyltransferase 1a gene are associated with variation in body composition and fasting lipid traits in yup'ik eskimos. |
publisher |
eScholarship, University of California |
publishDate |
2012 |
url |
https://escholarship.org/uc/item/4gt701w8 |
op_coverage |
175 - 184 |
genre |
eskimo* inuits Yup'ik Alaska |
genre_facet |
eskimo* inuits Yup'ik Alaska |
op_source |
Journal of lipid research, vol 53, iss 1 |
op_relation |
qt4gt701w8 https://escholarship.org/uc/item/4gt701w8 |
op_rights |
public |
_version_ |
1766402665820979200 |