Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance.

• Published in: Metabolomics
• Main Authors: Olmstead, Keedrian I, La Frano, Michael R, Fahrmann, Johannes, Grapov, Dmitry, Viscarra, Jose A, Newman, John W, Fiehn, Oliver, Crocker, Daniel E, Filipp, Fabian V, Ortiz, Rudy M
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: eScholarship, University of California 2017
• Subjects: Endocannabinoids; Fatty acids; Lipidomics; Metabolomics; Substrate metabolism; Nutrition; Diabetes; Obesity; Metabolic and endocrine; Analytical Chemistry; Biochemistry and Cell Biology; Clinical Sciences; Elephant Seals
• Online Access: https://escholarship.org/uc/item/3x70w0hv; https://escholarship.org/content/qt3x70w0hv/qt3x70w0hv.pdf; https://doi.org/10.1007/s11306-017-1186-y

Prolonged fasting in northern elephant seals (NES) is characterized by a reliance on lipid metabolism, conservation of protein, and reduced plasma insulin. During early fasting, glucose infusion previously reduced plasma free fatty acids (FFA); however, during late-fasting, it induced an atypical el...