Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction.
The observation that small isolated populations often suffer reduced fitness from inbreeding depression has guided conservation theory and practice for decades. However, investigating the genome-wide dynamics associated with inbreeding depression in natural populations is only now feasible with rela...
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2019
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ftcdlib:oai:escholarship.org:ark:/13030/qt3d45158p 2023-10-25T01:37:28+02:00 Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction. Räikkönen, Jannikke Vucetich, Leah Vucetich, John Peterson, Rolf Lohmueller, Kirk Wayne, Robert Robinson, Jacqueline 2019-05-01 application/pdf https://escholarship.org/uc/item/3d45158p unknown eScholarship, University of California qt3d45158p https://escholarship.org/uc/item/3d45158p public Science Advances, vol 5, iss 5 Abnormalities Multiple Animals Extinction Biological Female Genetic Variation Genetics Population Genome Homozygote Inbreeding Male Michigan Whole Genome Sequencing Wolves article 2019 ftcdlib 2023-09-25T18:04:45Z The observation that small isolated populations often suffer reduced fitness from inbreeding depression has guided conservation theory and practice for decades. However, investigating the genome-wide dynamics associated with inbreeding depression in natural populations is only now feasible with relatively inexpensive sequencing technology and annotated reference genomes. To characterize the genome-wide effects of intense inbreeding and isolation, we performed whole-genome sequencing and morphological analysis of an iconic inbred population, the gray wolves (Canis lupus) of Isle Royale. Through population genetic simulations and comparison with wolf genomes from a variety of demographic histories, we find evidence that severe inbreeding depression in this population is due to increased homozygosity of strongly deleterious recessive mutations. Our results have particular relevance in light of the recent translocation of wolves from the mainland to Isle Royale, as well as broader implications for management of genetic variation in the fragmented landscape of the modern world. Article in Journal/Newspaper Canis lupus University of California: eScholarship |
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University of California: eScholarship |
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topic |
Abnormalities Multiple Animals Extinction Biological Female Genetic Variation Genetics Population Genome Homozygote Inbreeding Male Michigan Whole Genome Sequencing Wolves |
spellingShingle |
Abnormalities Multiple Animals Extinction Biological Female Genetic Variation Genetics Population Genome Homozygote Inbreeding Male Michigan Whole Genome Sequencing Wolves Räikkönen, Jannikke Vucetich, Leah Vucetich, John Peterson, Rolf Lohmueller, Kirk Wayne, Robert Robinson, Jacqueline Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction. |
topic_facet |
Abnormalities Multiple Animals Extinction Biological Female Genetic Variation Genetics Population Genome Homozygote Inbreeding Male Michigan Whole Genome Sequencing Wolves |
description |
The observation that small isolated populations often suffer reduced fitness from inbreeding depression has guided conservation theory and practice for decades. However, investigating the genome-wide dynamics associated with inbreeding depression in natural populations is only now feasible with relatively inexpensive sequencing technology and annotated reference genomes. To characterize the genome-wide effects of intense inbreeding and isolation, we performed whole-genome sequencing and morphological analysis of an iconic inbred population, the gray wolves (Canis lupus) of Isle Royale. Through population genetic simulations and comparison with wolf genomes from a variety of demographic histories, we find evidence that severe inbreeding depression in this population is due to increased homozygosity of strongly deleterious recessive mutations. Our results have particular relevance in light of the recent translocation of wolves from the mainland to Isle Royale, as well as broader implications for management of genetic variation in the fragmented landscape of the modern world. |
format |
Article in Journal/Newspaper |
author |
Räikkönen, Jannikke Vucetich, Leah Vucetich, John Peterson, Rolf Lohmueller, Kirk Wayne, Robert Robinson, Jacqueline |
author_facet |
Räikkönen, Jannikke Vucetich, Leah Vucetich, John Peterson, Rolf Lohmueller, Kirk Wayne, Robert Robinson, Jacqueline |
author_sort |
Räikkönen, Jannikke |
title |
Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction. |
title_short |
Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction. |
title_full |
Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction. |
title_fullStr |
Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction. |
title_full_unstemmed |
Genomic signatures of extensive inbreeding in Isle Royale wolves, a population on the threshold of extinction. |
title_sort |
genomic signatures of extensive inbreeding in isle royale wolves, a population on the threshold of extinction. |
publisher |
eScholarship, University of California |
publishDate |
2019 |
url |
https://escholarship.org/uc/item/3d45158p |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_source |
Science Advances, vol 5, iss 5 |
op_relation |
qt3d45158p https://escholarship.org/uc/item/3d45158p |
op_rights |
public |
_version_ |
1780732428879396864 |