Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study.
Muscle composition may affect mortality risk, but prior studies have been limited to specific samples or less precise determination of muscle composition. We evaluated associations of thigh muscle composition, determined using computed tomography imaging, and knee extension strength with mortality r...
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ftcdlib:oai:escholarship.org:ark:/13030/qt3bv0g07p 2023-10-25T01:39:53+02:00 Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. Reinders, Ilse Murphy, Rachel Brouwer, Ingeborg Visser, Marjolein Launer, Lenore Siggeirsdottir, Kristin Eiriksdottir, Gudny Gudnason, Vilmundur Jonsson, Palmi Harris, Tamara Lang, Thomas 2016-01-01 application/pdf https://escholarship.org/uc/item/3bv0g07p unknown eScholarship, University of California qt3bv0g07p https://escholarship.org/uc/item/3bv0g07p public American Journal of Epidemiology, vol 183, iss 1 adipose tissue aging computed tomography mortality risk muscle muscle composition strength Adiposity Age Factors Aged 80 and over Body Mass Index Environment Female Gene-Environment Interaction Health Behavior Health Status Humans Iceland Male Mortality Muscle Strength Skeletal Obesity Proportional Hazards Models Risk Factors Socioeconomic Factors Thigh Tomography X-Ray Computed article 2016 ftcdlib 2023-09-25T18:05:00Z Muscle composition may affect mortality risk, but prior studies have been limited to specific samples or less precise determination of muscle composition. We evaluated associations of thigh muscle composition, determined using computed tomography imaging, and knee extension strength with mortality risk among 4,824 participants aged 76.4 (standard deviation (SD), 5.5) years from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (2002-2006). Cox proportional hazards models were used to estimate hazard ratios. After 8.8 years of follow-up, there were 1,942 deaths. For men, each SD-increment increase in muscle lean area, muscle quality, and strength was associated with lower mortality risk, with decreases ranging between 11% and 22%. Each SD-increment increase in intermuscular adipose tissue and intramuscular adipose tissue was associated with higher mortality risk (hazard ratio (HR) = 1.13 (95% confidence interval (CI): 1.06, 1.22) and HR = 1.23 (95% CI: 1.15, 1.30), respectively). For women, each SD-increment increase in muscle lean area, muscle quality, and strength was associated with lower mortality risk, with decreases ranging between 12% and 19%. Greater intramuscular adipose tissue was associated with an 8% higher mortality risk (HR = 1.08, 95% CI: 1.01, 1.16). This study shows that muscle composition is associated with mortality risk. These results also show the importance of improving muscle strength and area and lowering muscle adipose tissue infiltration. Article in Journal/Newspaper Iceland University of California: eScholarship |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
adipose tissue aging computed tomography mortality risk muscle muscle composition strength Adiposity Age Factors Aged 80 and over Body Mass Index Environment Female Gene-Environment Interaction Health Behavior Health Status Humans Iceland Male Mortality Muscle Strength Skeletal Obesity Proportional Hazards Models Risk Factors Socioeconomic Factors Thigh Tomography X-Ray Computed |
spellingShingle |
adipose tissue aging computed tomography mortality risk muscle muscle composition strength Adiposity Age Factors Aged 80 and over Body Mass Index Environment Female Gene-Environment Interaction Health Behavior Health Status Humans Iceland Male Mortality Muscle Strength Skeletal Obesity Proportional Hazards Models Risk Factors Socioeconomic Factors Thigh Tomography X-Ray Computed Reinders, Ilse Murphy, Rachel Brouwer, Ingeborg Visser, Marjolein Launer, Lenore Siggeirsdottir, Kristin Eiriksdottir, Gudny Gudnason, Vilmundur Jonsson, Palmi Harris, Tamara Lang, Thomas Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. |
topic_facet |
adipose tissue aging computed tomography mortality risk muscle muscle composition strength Adiposity Age Factors Aged 80 and over Body Mass Index Environment Female Gene-Environment Interaction Health Behavior Health Status Humans Iceland Male Mortality Muscle Strength Skeletal Obesity Proportional Hazards Models Risk Factors Socioeconomic Factors Thigh Tomography X-Ray Computed |
description |
Muscle composition may affect mortality risk, but prior studies have been limited to specific samples or less precise determination of muscle composition. We evaluated associations of thigh muscle composition, determined using computed tomography imaging, and knee extension strength with mortality risk among 4,824 participants aged 76.4 (standard deviation (SD), 5.5) years from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (2002-2006). Cox proportional hazards models were used to estimate hazard ratios. After 8.8 years of follow-up, there were 1,942 deaths. For men, each SD-increment increase in muscle lean area, muscle quality, and strength was associated with lower mortality risk, with decreases ranging between 11% and 22%. Each SD-increment increase in intermuscular adipose tissue and intramuscular adipose tissue was associated with higher mortality risk (hazard ratio (HR) = 1.13 (95% confidence interval (CI): 1.06, 1.22) and HR = 1.23 (95% CI: 1.15, 1.30), respectively). For women, each SD-increment increase in muscle lean area, muscle quality, and strength was associated with lower mortality risk, with decreases ranging between 12% and 19%. Greater intramuscular adipose tissue was associated with an 8% higher mortality risk (HR = 1.08, 95% CI: 1.01, 1.16). This study shows that muscle composition is associated with mortality risk. These results also show the importance of improving muscle strength and area and lowering muscle adipose tissue infiltration. |
format |
Article in Journal/Newspaper |
author |
Reinders, Ilse Murphy, Rachel Brouwer, Ingeborg Visser, Marjolein Launer, Lenore Siggeirsdottir, Kristin Eiriksdottir, Gudny Gudnason, Vilmundur Jonsson, Palmi Harris, Tamara Lang, Thomas |
author_facet |
Reinders, Ilse Murphy, Rachel Brouwer, Ingeborg Visser, Marjolein Launer, Lenore Siggeirsdottir, Kristin Eiriksdottir, Gudny Gudnason, Vilmundur Jonsson, Palmi Harris, Tamara Lang, Thomas |
author_sort |
Reinders, Ilse |
title |
Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. |
title_short |
Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. |
title_full |
Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. |
title_fullStr |
Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. |
title_full_unstemmed |
Muscle Quality and Myosteatosis: Novel Associations With Mortality Risk: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study. |
title_sort |
muscle quality and myosteatosis: novel associations with mortality risk: the age, gene/environment susceptibility (ages)-reykjavik study. |
publisher |
eScholarship, University of California |
publishDate |
2016 |
url |
https://escholarship.org/uc/item/3bv0g07p |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
American Journal of Epidemiology, vol 183, iss 1 |
op_relation |
qt3bv0g07p https://escholarship.org/uc/item/3bv0g07p |
op_rights |
public |
_version_ |
1780735467007770624 |