Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections.
The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared wi...
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ftcdlib:oai:escholarship.org:ark:/13030/qt2tr7j30r 2023-11-12T04:14:48+01:00 Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. Komadina, N Sullivan, S Kedzierska, K Quiñones-Parra, S Leder, K McVernon, J 2019-01-01 application/pdf https://escholarship.org/uc/item/2tr7j30r unknown eScholarship, University of California qt2tr7j30r https://escholarship.org/uc/item/2tr7j30r public Avian flu H5N1 H7N9 immunogenic peptides influenza A Age Distribution Antigens Viral China Disease Susceptibility Environmental Exposure Female Humans Incidence Influenza A Virus H5N1 Subtype H7N9 Subtype Influenza Human Male Peptides article 2019 ftcdlib 2023-10-30T19:04:42Z The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns observed for H5N1 and H7N9 viruses. A comparison of relatedness of immunogenic peptides between historical human strains and the two avian emerged viruses was undertaken for a possible explanation in the differences in age incidence observed. There appeared to be some relationship between past exposure to related peptides and the lower number of H5N1 virus cases in older populations, however the relationship between prior exposure and older populations among H7N9 virus patients was less clear. Article in Journal/Newspaper Avian flu University of California: eScholarship |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Avian flu H5N1 H7N9 immunogenic peptides influenza A Age Distribution Antigens Viral China Disease Susceptibility Environmental Exposure Female Humans Incidence Influenza A Virus H5N1 Subtype H7N9 Subtype Influenza Human Male Peptides |
spellingShingle |
Avian flu H5N1 H7N9 immunogenic peptides influenza A Age Distribution Antigens Viral China Disease Susceptibility Environmental Exposure Female Humans Incidence Influenza A Virus H5N1 Subtype H7N9 Subtype Influenza Human Male Peptides Komadina, N Sullivan, S Kedzierska, K Quiñones-Parra, S Leder, K McVernon, J Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. |
topic_facet |
Avian flu H5N1 H7N9 immunogenic peptides influenza A Age Distribution Antigens Viral China Disease Susceptibility Environmental Exposure Female Humans Incidence Influenza A Virus H5N1 Subtype H7N9 Subtype Influenza Human Male Peptides |
description |
The epidemiology of H5N1 and H7N9 avian viruses of humans infected in China differs despite both viruses being avian reassortants that have inherited six internal genes from a common ancestor, H9N2. The median age of infected populations is substantially younger for H5N1 virus (26 years) compared with H7N9 virus (63 years). Population susceptibility to infection with seasonal influenza is understood to be influenced by cross-reactive CD8+ T cells directed towards immunogenic peptides derived from internal viral proteins which may provide some level of protection against further influenza infection. Prior exposure to seasonal influenza peptides may influence the age-related infection patterns observed for H5N1 and H7N9 viruses. A comparison of relatedness of immunogenic peptides between historical human strains and the two avian emerged viruses was undertaken for a possible explanation in the differences in age incidence observed. There appeared to be some relationship between past exposure to related peptides and the lower number of H5N1 virus cases in older populations, however the relationship between prior exposure and older populations among H7N9 virus patients was less clear. |
format |
Article in Journal/Newspaper |
author |
Komadina, N Sullivan, S Kedzierska, K Quiñones-Parra, S Leder, K McVernon, J |
author_facet |
Komadina, N Sullivan, S Kedzierska, K Quiñones-Parra, S Leder, K McVernon, J |
author_sort |
Komadina, N |
title |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. |
title_short |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. |
title_full |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. |
title_fullStr |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. |
title_full_unstemmed |
Prior exposure to immunogenic peptides found in human influenza A viruses may influence the age distribution of cases with avian influenza H5N1 and H7N9 virus infections. |
title_sort |
prior exposure to immunogenic peptides found in human influenza a viruses may influence the age distribution of cases with avian influenza h5n1 and h7n9 virus infections. |
publisher |
eScholarship, University of California |
publishDate |
2019 |
url |
https://escholarship.org/uc/item/2tr7j30r |
genre |
Avian flu |
genre_facet |
Avian flu |
op_relation |
qt2tr7j30r https://escholarship.org/uc/item/2tr7j30r |
op_rights |
public |
_version_ |
1782332351398805504 |