Genetics of canine subvalvular aortic stenosis (SAS)

• Main Authors: Ontiveros, Eric S, Stern, Joshua A
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: eScholarship, University of California 2021
• Subjects: Genetics; Cardiovascular; Pediatric; Heart Disease; 2.1 Biological and endogenous factors; Aetiology; Aortic stenosis; Cardiac genetics; Congenital heart disease; Subaortic stenosis; Veterinary; Bouvier; Flandres; Newfoundland
• Online Access: https://escholarship.org/uc/item/2nr0m8z3

Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring...