Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages.
The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this quest...
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2024
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ftcdlib:oai:escholarship.org:ark:/13030/qt2mv6q0xm 2024-06-23T07:53:58+00:00 Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. Di, Yazheng Mefford, Joel Rahmani, Elior Wang, Jinhan Ravi, Vijay Gorla, Aditya Alwan, Abeer Zhu, Tingshao Flint, Jonathan Frederic Rest 2024-05-07 application/pdf https://escholarship.org/uc/item/2mv6q0xm unknown eScholarship, University of California qt2mv6q0xm https://escholarship.org/uc/item/2mv6q0xm public Communications Biology, vol 7, iss 1 Humans Male Language Female Genome-Wide Association Study Polymorphism Single Nucleotide Adult Iceland Case-Control Studies Middle Aged Voice Pitch Perception Asian People article 2024 ftcdlib 2024-05-29T00:34:23Z The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this question by searching for genetic associations with interindividual variation in median pitch in a Chinese major depression case-control cohort and compared our results with a genome-wide association study from Iceland. The same genetic variant, rs11046212-T in an intron of the ABCC9 gene, was one of the most strongly associated loci with median pitch in both samples. Our meta-analysis revealed four genome-wide significant hits, including two novel associations. The discovery of genetic variants influencing vocal pitch across both tonal and non-tonal languages suggests the possibility of a common genetic contribution to the human vocal system shared in two distinct populations with languages that differ in tonality (Icelandic and Mandarin). Article in Journal/Newspaper Iceland University of California: eScholarship |
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University of California: eScholarship |
op_collection_id |
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topic |
Humans Male Language Female Genome-Wide Association Study Polymorphism Single Nucleotide Adult Iceland Case-Control Studies Middle Aged Voice Pitch Perception Asian People |
spellingShingle |
Humans Male Language Female Genome-Wide Association Study Polymorphism Single Nucleotide Adult Iceland Case-Control Studies Middle Aged Voice Pitch Perception Asian People Di, Yazheng Mefford, Joel Rahmani, Elior Wang, Jinhan Ravi, Vijay Gorla, Aditya Alwan, Abeer Zhu, Tingshao Flint, Jonathan Frederic Rest Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
topic_facet |
Humans Male Language Female Genome-Wide Association Study Polymorphism Single Nucleotide Adult Iceland Case-Control Studies Middle Aged Voice Pitch Perception Asian People |
description |
The genetic influence on human vocal pitch in tonal and non-tonal languages remains largely unknown. In tonal languages, such as Mandarin Chinese, pitch changes differentiate word meanings, whereas in non-tonal languages, such as Icelandic, pitch is used to convey intonation. We addressed this question by searching for genetic associations with interindividual variation in median pitch in a Chinese major depression case-control cohort and compared our results with a genome-wide association study from Iceland. The same genetic variant, rs11046212-T in an intron of the ABCC9 gene, was one of the most strongly associated loci with median pitch in both samples. Our meta-analysis revealed four genome-wide significant hits, including two novel associations. The discovery of genetic variants influencing vocal pitch across both tonal and non-tonal languages suggests the possibility of a common genetic contribution to the human vocal system shared in two distinct populations with languages that differ in tonality (Icelandic and Mandarin). |
format |
Article in Journal/Newspaper |
author |
Di, Yazheng Mefford, Joel Rahmani, Elior Wang, Jinhan Ravi, Vijay Gorla, Aditya Alwan, Abeer Zhu, Tingshao Flint, Jonathan Frederic Rest |
author_facet |
Di, Yazheng Mefford, Joel Rahmani, Elior Wang, Jinhan Ravi, Vijay Gorla, Aditya Alwan, Abeer Zhu, Tingshao Flint, Jonathan Frederic Rest |
author_sort |
Di, Yazheng |
title |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_short |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_full |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_fullStr |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_full_unstemmed |
Genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
title_sort |
genetic association analysis of human median voice pitch identifies a common locus for tonal and non-tonal languages. |
publisher |
eScholarship, University of California |
publishDate |
2024 |
url |
https://escholarship.org/uc/item/2mv6q0xm |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Communications Biology, vol 7, iss 1 |
op_relation |
qt2mv6q0xm https://escholarship.org/uc/item/2mv6q0xm |
op_rights |
public |
_version_ |
1802645878080536576 |