Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study
In this case-cohort study, we used data-driven computational anatomy approaches to assess within and between sex spatial differences in proximal femoral bone characteristics in relation to incident hip fracture. One hundred male and 234 female incident hip fracture cases, and 1047 randomly selected...
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2018
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ftcdlib:oai:escholarship.org:ark:/13030/qt2gq7v0bc 2023-11-05T03:43:01+01:00 Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study Marques, Elisa A Carballido-Gamio, Julio Gudnason, Vilmundur Sigurdsson, Gunnar Sigurdsson, Sigurdur Aspelund, Thor Siggeirsdottir, Kristin Launer, Lenore Eiriksdottir, Gudny Lang, Thomas Harris, Tamara B 2018-09-01 application/pdf https://escholarship.org/uc/item/2gq7v0bc unknown eScholarship, University of California qt2gq7v0bc https://escholarship.org/uc/item/2gq7v0bc public Biomedical and Clinical Sciences Clinical Sciences Osteoporosis Clinical Research Prevention Physical Injury - Accidents and Adverse Effects Musculoskeletal Aged 80 and over Aging Bone Density Cohort Studies Female Femur Hip Fractures Humans Iceland Male Sex Characteristics Bone Quantitative computed tomography Bone mineral density Cortical bone thickness Voxel-based morphometry (VBM Statistical parametric mapping Tensor-based morphometry Voxel-based morphometry Biological Sciences Engineering Medical and Health Sciences Endocrinology & Metabolism article 2018 ftcdlib 2023-10-09T18:08:15Z In this case-cohort study, we used data-driven computational anatomy approaches to assess within and between sex spatial differences in proximal femoral bone characteristics in relation to incident hip fracture. One hundred male and 234 female incident hip fracture cases, and 1047 randomly selected noncase subcohort participants (562 female) were chosen from the population-based AGES-Reykjavik study (mean age of 77 years). The baseline -i.e. before hip fracture- hip quantitative computed tomography scans of these subjects were analyzed using voxel-based morphometry, tensor-based morphometry, and surface-based statistical parametric mapping to assess the spatial distribution of volumetric bone mineral density (vBMD), internal structure, and cortical bone properties (thickness, vBMD and trabecular vBMD adjacent to the endosteal surface) of the proximal femur, respectively, in relation to incident hip fracture. Results showed that in both men and women: 1) the superior aspect of the femoral neck and the trochanteric region (except for cortical bone thickness) were consistently identified as being associated with incident hip fracture, and 2) differences in bone properties between noncases and incident hip fracture cases followed similar trends, were located at compatible regions, and manifested heterogeneity in the spatial distribution of their magnitude with focal regions showing larger differences. With respect to sex differences, most of the regions with a significant interaction between fracture group and sex showed: 1) differences of greater magnitude in men between noncases and incident hip fracture cases with different spatial distributions for all bone properties with the exception of cortical bone thickness, and 2) that while most of these regions showed better bone quality in male cases than in female cases, female cases showed higher vBMD in the principal compressive group and higher endotrabecular vBMD at several regions including the anterior, posterior, and lateral aspects of the proximal femur. These ... Article in Journal/Newspaper Iceland University of California: eScholarship |
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Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Biomedical and Clinical Sciences Clinical Sciences Osteoporosis Clinical Research Prevention Physical Injury - Accidents and Adverse Effects Musculoskeletal Aged 80 and over Aging Bone Density Cohort Studies Female Femur Hip Fractures Humans Iceland Male Sex Characteristics Bone Quantitative computed tomography Bone mineral density Cortical bone thickness Voxel-based morphometry (VBM Statistical parametric mapping Tensor-based morphometry Voxel-based morphometry Biological Sciences Engineering Medical and Health Sciences Endocrinology & Metabolism |
spellingShingle |
Biomedical and Clinical Sciences Clinical Sciences Osteoporosis Clinical Research Prevention Physical Injury - Accidents and Adverse Effects Musculoskeletal Aged 80 and over Aging Bone Density Cohort Studies Female Femur Hip Fractures Humans Iceland Male Sex Characteristics Bone Quantitative computed tomography Bone mineral density Cortical bone thickness Voxel-based morphometry (VBM Statistical parametric mapping Tensor-based morphometry Voxel-based morphometry Biological Sciences Engineering Medical and Health Sciences Endocrinology & Metabolism Marques, Elisa A Carballido-Gamio, Julio Gudnason, Vilmundur Sigurdsson, Gunnar Sigurdsson, Sigurdur Aspelund, Thor Siggeirsdottir, Kristin Launer, Lenore Eiriksdottir, Gudny Lang, Thomas Harris, Tamara B Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study |
topic_facet |
Biomedical and Clinical Sciences Clinical Sciences Osteoporosis Clinical Research Prevention Physical Injury - Accidents and Adverse Effects Musculoskeletal Aged 80 and over Aging Bone Density Cohort Studies Female Femur Hip Fractures Humans Iceland Male Sex Characteristics Bone Quantitative computed tomography Bone mineral density Cortical bone thickness Voxel-based morphometry (VBM Statistical parametric mapping Tensor-based morphometry Voxel-based morphometry Biological Sciences Engineering Medical and Health Sciences Endocrinology & Metabolism |
description |
In this case-cohort study, we used data-driven computational anatomy approaches to assess within and between sex spatial differences in proximal femoral bone characteristics in relation to incident hip fracture. One hundred male and 234 female incident hip fracture cases, and 1047 randomly selected noncase subcohort participants (562 female) were chosen from the population-based AGES-Reykjavik study (mean age of 77 years). The baseline -i.e. before hip fracture- hip quantitative computed tomography scans of these subjects were analyzed using voxel-based morphometry, tensor-based morphometry, and surface-based statistical parametric mapping to assess the spatial distribution of volumetric bone mineral density (vBMD), internal structure, and cortical bone properties (thickness, vBMD and trabecular vBMD adjacent to the endosteal surface) of the proximal femur, respectively, in relation to incident hip fracture. Results showed that in both men and women: 1) the superior aspect of the femoral neck and the trochanteric region (except for cortical bone thickness) were consistently identified as being associated with incident hip fracture, and 2) differences in bone properties between noncases and incident hip fracture cases followed similar trends, were located at compatible regions, and manifested heterogeneity in the spatial distribution of their magnitude with focal regions showing larger differences. With respect to sex differences, most of the regions with a significant interaction between fracture group and sex showed: 1) differences of greater magnitude in men between noncases and incident hip fracture cases with different spatial distributions for all bone properties with the exception of cortical bone thickness, and 2) that while most of these regions showed better bone quality in male cases than in female cases, female cases showed higher vBMD in the principal compressive group and higher endotrabecular vBMD at several regions including the anterior, posterior, and lateral aspects of the proximal femur. These ... |
format |
Article in Journal/Newspaper |
author |
Marques, Elisa A Carballido-Gamio, Julio Gudnason, Vilmundur Sigurdsson, Gunnar Sigurdsson, Sigurdur Aspelund, Thor Siggeirsdottir, Kristin Launer, Lenore Eiriksdottir, Gudny Lang, Thomas Harris, Tamara B |
author_facet |
Marques, Elisa A Carballido-Gamio, Julio Gudnason, Vilmundur Sigurdsson, Gunnar Sigurdsson, Sigurdur Aspelund, Thor Siggeirsdottir, Kristin Launer, Lenore Eiriksdottir, Gudny Lang, Thomas Harris, Tamara B |
author_sort |
Marques, Elisa A |
title |
Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study |
title_short |
Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study |
title_full |
Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study |
title_fullStr |
Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study |
title_full_unstemmed |
Sex differences in the spatial distribution of bone in relation to incident hip fracture: Findings from the AGES-Reykjavik study |
title_sort |
sex differences in the spatial distribution of bone in relation to incident hip fracture: findings from the ages-reykjavik study |
publisher |
eScholarship, University of California |
publishDate |
2018 |
url |
https://escholarship.org/uc/item/2gq7v0bc |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
qt2gq7v0bc https://escholarship.org/uc/item/2gq7v0bc |
op_rights |
public |
_version_ |
1781700760182980608 |