Population attributable fraction of incident HIV infections associated with alcohol consumption in fishing communities around Lake Victoria, Uganda.
BackgroundAlthough the association between alcohol consumption and HIV risk is well documented, few studies have examined the magnitude of new HIV infections that could be prevented by controlling alcohol use. We report the population attributable fraction (PAF) of incident HIV infections due to alc...
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ftcdlib:oai:escholarship.org/ark:/13030/qt9dm0s6w5 2023-05-15T16:30:25+02:00 Population attributable fraction of incident HIV infections associated with alcohol consumption in fishing communities around Lake Victoria, Uganda. Kiwanuka, Noah Ssetaala, Ali Ssekandi, Ismail Nalutaaya, Annet Kitandwe, Paul Kato Ssempiira, Julius Bagaya, Bernard Ssentalo Balyegisawa, Apolo Kaleebu, Pontiano Hahn, Judith Lindan, Christina Sewankambo, Nelson Kaulukusi e0171200 2017-01-01 application/pdf https://escholarship.org/uc/item/9dm0s6w5 unknown eScholarship, University of California qt9dm0s6w5 https://escholarship.org/uc/item/9dm0s6w5 public PloS one, vol 12, iss 2 Humans HIV-1 HIV Infections Incidence Risk Factors Longitudinal Studies Alcohol Drinking Risk-Taking Fisheries Adolescent Adult Middle Aged Uganda Female Male Young Adult Lakes General Science & Technology article 2017 ftcdlib 2021-01-24T17:38:23Z BackgroundAlthough the association between alcohol consumption and HIV risk is well documented, few studies have examined the magnitude of new HIV infections that could be prevented by controlling alcohol use. We report the population attributable fraction (PAF) of incident HIV infections due to alcohol consumption among the HIV high-risk population of fishing communities along Lake Victoria, Uganda.MethodsIn a community-based cohort study, 1607 HIV sero-negative participants aged 18-49 years were enrolled from eight fishing communities along Lake Victoria, Uganda. At follow up 12 months later, 1288 (80.1%) were seen and interviewed. At baseline and follow-up visits, participants completed interviewer-administered questionnaires on alcohol consumption, demographics, and sexual risk behavior, and were tested for HIV infection. HIV incidence and adjusted incident rate ratios (adjusted IRRs) were estimated using Poisson regression models; the crude and adjusted PAFs of incident HIV infections associated with alcohol consumption were calculated using the Greenland and Drescher method for cohort studies.ResultsAmong the 1288 participants seen at follow up, 53.5% reported drinking alcohol of whom 24.4% drank occasionally (2 days a week or less) and 29.1% drank regularly (3-7 days a week). Forty eight incident HIV infections occurred giving an incidence rate of 3.39/100 person years at-risk (pyar) (95% CI, 2.55-4.49). Compared to non-drinkers, the adjusted IRR of HIV was 3.09 (1.13-8.46) among occasional drinkers and 5.34 (2.04-13.97) among regular drinkers. The overall adjusted PAF of incident HIV infections due alcohol was 64.1 (95% CI; 23.5-83.1); ranging from 52.3 (11.9-74.2) among Muslims to 71.2 (32.6-87.7) for participants who reported ≥ 2 sexual partners in the past 12 months.ConclusionIn fishing communities along Lake Victoria, Uganda, 64% of new HIV infections can be attributed to drinking alcohol. Interventions to reduce alcohol consumption should be integrated in HIV/AIDS prevention activities for populations in whom both HIV and alcohol consumption are highly prevalent. Article in Journal/Newspaper Greenland University of California: eScholarship Greenland |
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Open Polar |
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University of California: eScholarship |
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ftcdlib |
language |
unknown |
topic |
Humans HIV-1 HIV Infections Incidence Risk Factors Longitudinal Studies Alcohol Drinking Risk-Taking Fisheries Adolescent Adult Middle Aged Uganda Female Male Young Adult Lakes General Science & Technology |
spellingShingle |
Humans HIV-1 HIV Infections Incidence Risk Factors Longitudinal Studies Alcohol Drinking Risk-Taking Fisheries Adolescent Adult Middle Aged Uganda Female Male Young Adult Lakes General Science & Technology Kiwanuka, Noah Ssetaala, Ali Ssekandi, Ismail Nalutaaya, Annet Kitandwe, Paul Kato Ssempiira, Julius Bagaya, Bernard Ssentalo Balyegisawa, Apolo Kaleebu, Pontiano Hahn, Judith Lindan, Christina Sewankambo, Nelson Kaulukusi Population attributable fraction of incident HIV infections associated with alcohol consumption in fishing communities around Lake Victoria, Uganda. |
topic_facet |
Humans HIV-1 HIV Infections Incidence Risk Factors Longitudinal Studies Alcohol Drinking Risk-Taking Fisheries Adolescent Adult Middle Aged Uganda Female Male Young Adult Lakes General Science & Technology |
description |
BackgroundAlthough the association between alcohol consumption and HIV risk is well documented, few studies have examined the magnitude of new HIV infections that could be prevented by controlling alcohol use. We report the population attributable fraction (PAF) of incident HIV infections due to alcohol consumption among the HIV high-risk population of fishing communities along Lake Victoria, Uganda.MethodsIn a community-based cohort study, 1607 HIV sero-negative participants aged 18-49 years were enrolled from eight fishing communities along Lake Victoria, Uganda. At follow up 12 months later, 1288 (80.1%) were seen and interviewed. At baseline and follow-up visits, participants completed interviewer-administered questionnaires on alcohol consumption, demographics, and sexual risk behavior, and were tested for HIV infection. HIV incidence and adjusted incident rate ratios (adjusted IRRs) were estimated using Poisson regression models; the crude and adjusted PAFs of incident HIV infections associated with alcohol consumption were calculated using the Greenland and Drescher method for cohort studies.ResultsAmong the 1288 participants seen at follow up, 53.5% reported drinking alcohol of whom 24.4% drank occasionally (2 days a week or less) and 29.1% drank regularly (3-7 days a week). Forty eight incident HIV infections occurred giving an incidence rate of 3.39/100 person years at-risk (pyar) (95% CI, 2.55-4.49). Compared to non-drinkers, the adjusted IRR of HIV was 3.09 (1.13-8.46) among occasional drinkers and 5.34 (2.04-13.97) among regular drinkers. The overall adjusted PAF of incident HIV infections due alcohol was 64.1 (95% CI; 23.5-83.1); ranging from 52.3 (11.9-74.2) among Muslims to 71.2 (32.6-87.7) for participants who reported ≥ 2 sexual partners in the past 12 months.ConclusionIn fishing communities along Lake Victoria, Uganda, 64% of new HIV infections can be attributed to drinking alcohol. Interventions to reduce alcohol consumption should be integrated in HIV/AIDS prevention activities for populations in whom both HIV and alcohol consumption are highly prevalent. |
format |
Article in Journal/Newspaper |
author |
Kiwanuka, Noah Ssetaala, Ali Ssekandi, Ismail Nalutaaya, Annet Kitandwe, Paul Kato Ssempiira, Julius Bagaya, Bernard Ssentalo Balyegisawa, Apolo Kaleebu, Pontiano Hahn, Judith Lindan, Christina Sewankambo, Nelson Kaulukusi |
author_facet |
Kiwanuka, Noah Ssetaala, Ali Ssekandi, Ismail Nalutaaya, Annet Kitandwe, Paul Kato Ssempiira, Julius Bagaya, Bernard Ssentalo Balyegisawa, Apolo Kaleebu, Pontiano Hahn, Judith Lindan, Christina Sewankambo, Nelson Kaulukusi |
author_sort |
Kiwanuka, Noah |
title |
Population attributable fraction of incident HIV infections associated with alcohol consumption in fishing communities around Lake Victoria, Uganda. |
title_short |
Population attributable fraction of incident HIV infections associated with alcohol consumption in fishing communities around Lake Victoria, Uganda. |
title_full |
Population attributable fraction of incident HIV infections associated with alcohol consumption in fishing communities around Lake Victoria, Uganda. |
title_fullStr |
Population attributable fraction of incident HIV infections associated with alcohol consumption in fishing communities around Lake Victoria, Uganda. |
title_full_unstemmed |
Population attributable fraction of incident HIV infections associated with alcohol consumption in fishing communities around Lake Victoria, Uganda. |
title_sort |
population attributable fraction of incident hiv infections associated with alcohol consumption in fishing communities around lake victoria, uganda. |
publisher |
eScholarship, University of California |
publishDate |
2017 |
url |
https://escholarship.org/uc/item/9dm0s6w5 |
op_coverage |
e0171200 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland |
genre_facet |
Greenland |
op_source |
PloS one, vol 12, iss 2 |
op_relation |
qt9dm0s6w5 https://escholarship.org/uc/item/9dm0s6w5 |
op_rights |
public |
_version_ |
1766020150689005568 |