DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people.
A large body of evidence links a high dietary intake of n-3 (ω-3) polyunsaturated fatty acids (PUFAs) with improved cardiometabolic outcomes. Recent studies suggested that the biologic processes underlying the observed associations may involve epigenetic changes, specifically DNA methylation. To eva...
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ftcdlib:oai:escholarship.org/ark:/13030/qt72z2p49k 2023-05-15T16:55:29+02:00 DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. Aslibekyan, Stella Wiener, Howard W Havel, Peter J Stanhope, Kimber L O'Brien, Diane M Hopkins, Scarlett E Absher, Devin M Tiwari, Hemant K Boyer, Bert B 425 - 430 2014-04-01 application/pdf https://escholarship.org/uc/item/72z2p49k unknown eScholarship, University of California qt72z2p49k https://escholarship.org/uc/item/72z2p49k public The Journal of nutrition, vol 144, iss 4 Erythrocytes Humans Cardiovascular Diseases Diabetes Mellitus Nitrogen Isotopes Fatty Acids Omega-3 Risk Factors Cross-Sectional Studies DNA Methylation Epigenesis Genetic Adolescent Adult Aged Inuits Alaska Female Male Aquatic Organisms Diet High-Fat Biomarkers Nutrition and Dietetics Animal Production Food Sciences Nutrition & Dietetics article 2014 ftcdlib 2020-01-24T23:54:48Z A large body of evidence links a high dietary intake of n-3 (ω-3) polyunsaturated fatty acids (PUFAs) with improved cardiometabolic outcomes. Recent studies suggested that the biologic processes underlying the observed associations may involve epigenetic changes, specifically DNA methylation. To evaluate changes in methylation associated with n-3 PUFA intake, we conducted an epigenome-wide methylation association study of long-chain n-3 PUFA intake and tested associations between the diabetes- and cardiovascular disease-related traits. We assessed DNA methylation at ∼470,000 cytosine-phosphate-guanine (CpG) sites in a cross-sectional study of 185 Yup'ik Alaska Native individuals representing the top and bottom deciles of PUFA intake. Linear regression models were used to test for the associations of interest, adjusting for age, sex, and community group. We identified 27 differentially methylated CpG sites at biologically relevant regions that reached epigenome-wide significance (P < 1 × 10⁻⁷). Specifically, regions on chromosomes 3 (helicase-like transcription factor), 10 (actin α 2 smooth muscle/Fas cell surface death receptor), and 16 (protease serine 36/C16 open reading frame 67) each harbored 2 significant correlates of n-3 PUFA intake. In conclusion, we present promising evidence of association between several biologically relevant epigenetic markers and long-term intake of marine-derived n-3 PUFAs. Article in Journal/Newspaper inuits Yup'ik Alaska University of California: eScholarship |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Erythrocytes Humans Cardiovascular Diseases Diabetes Mellitus Nitrogen Isotopes Fatty Acids Omega-3 Risk Factors Cross-Sectional Studies DNA Methylation Epigenesis Genetic Adolescent Adult Aged Inuits Alaska Female Male Aquatic Organisms Diet High-Fat Biomarkers Nutrition and Dietetics Animal Production Food Sciences Nutrition & Dietetics |
spellingShingle |
Erythrocytes Humans Cardiovascular Diseases Diabetes Mellitus Nitrogen Isotopes Fatty Acids Omega-3 Risk Factors Cross-Sectional Studies DNA Methylation Epigenesis Genetic Adolescent Adult Aged Inuits Alaska Female Male Aquatic Organisms Diet High-Fat Biomarkers Nutrition and Dietetics Animal Production Food Sciences Nutrition & Dietetics Aslibekyan, Stella Wiener, Howard W Havel, Peter J Stanhope, Kimber L O'Brien, Diane M Hopkins, Scarlett E Absher, Devin M Tiwari, Hemant K Boyer, Bert B DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. |
topic_facet |
Erythrocytes Humans Cardiovascular Diseases Diabetes Mellitus Nitrogen Isotopes Fatty Acids Omega-3 Risk Factors Cross-Sectional Studies DNA Methylation Epigenesis Genetic Adolescent Adult Aged Inuits Alaska Female Male Aquatic Organisms Diet High-Fat Biomarkers Nutrition and Dietetics Animal Production Food Sciences Nutrition & Dietetics |
description |
A large body of evidence links a high dietary intake of n-3 (ω-3) polyunsaturated fatty acids (PUFAs) with improved cardiometabolic outcomes. Recent studies suggested that the biologic processes underlying the observed associations may involve epigenetic changes, specifically DNA methylation. To evaluate changes in methylation associated with n-3 PUFA intake, we conducted an epigenome-wide methylation association study of long-chain n-3 PUFA intake and tested associations between the diabetes- and cardiovascular disease-related traits. We assessed DNA methylation at ∼470,000 cytosine-phosphate-guanine (CpG) sites in a cross-sectional study of 185 Yup'ik Alaska Native individuals representing the top and bottom deciles of PUFA intake. Linear regression models were used to test for the associations of interest, adjusting for age, sex, and community group. We identified 27 differentially methylated CpG sites at biologically relevant regions that reached epigenome-wide significance (P < 1 × 10⁻⁷). Specifically, regions on chromosomes 3 (helicase-like transcription factor), 10 (actin α 2 smooth muscle/Fas cell surface death receptor), and 16 (protease serine 36/C16 open reading frame 67) each harbored 2 significant correlates of n-3 PUFA intake. In conclusion, we present promising evidence of association between several biologically relevant epigenetic markers and long-term intake of marine-derived n-3 PUFAs. |
format |
Article in Journal/Newspaper |
author |
Aslibekyan, Stella Wiener, Howard W Havel, Peter J Stanhope, Kimber L O'Brien, Diane M Hopkins, Scarlett E Absher, Devin M Tiwari, Hemant K Boyer, Bert B |
author_facet |
Aslibekyan, Stella Wiener, Howard W Havel, Peter J Stanhope, Kimber L O'Brien, Diane M Hopkins, Scarlett E Absher, Devin M Tiwari, Hemant K Boyer, Bert B |
author_sort |
Aslibekyan, Stella |
title |
DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. |
title_short |
DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. |
title_full |
DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. |
title_fullStr |
DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. |
title_full_unstemmed |
DNA methylation patterns are associated with n-3 fatty acid intake in Yup'ik people. |
title_sort |
dna methylation patterns are associated with n-3 fatty acid intake in yup'ik people. |
publisher |
eScholarship, University of California |
publishDate |
2014 |
url |
https://escholarship.org/uc/item/72z2p49k |
op_coverage |
425 - 430 |
genre |
inuits Yup'ik Alaska |
genre_facet |
inuits Yup'ik Alaska |
op_source |
The Journal of nutrition, vol 144, iss 4 |
op_relation |
qt72z2p49k https://escholarship.org/uc/item/72z2p49k |
op_rights |
public |
_version_ |
1766046480871718912 |