Genetics of canine subvalvular aortic stenosis (SAS).
Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring...
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2021
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ftcdlib:oai:escholarship.org/ark:/13030/qt2nr0m8z3 2023-05-15T17:22:10+02:00 Genetics of canine subvalvular aortic stenosis (SAS). Ontiveros, Eric S Stern, Joshua A 4 2021-05-07 application/pdf https://escholarship.org/uc/item/2nr0m8z3 unknown eScholarship, University of California qt2nr0m8z3 https://escholarship.org/uc/item/2nr0m8z3 public Canine medicine and genetics, vol 8, iss 1 Aortic stenosis Cardiac genetics Congenital heart disease Subaortic stenosis Veterinary article 2021 ftcdlib 2021-05-30T17:54:06Z Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity. This review is focused on the prevalence, inheritance pattern, and current genetic insights of canine SAS. The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital. The mode of inheritance for this disease has also been described in breeds with a high disease prevalence such as the Bullmastiff, Bouvier des Flandres, Dogue de Bordeaux, Golden Retriever, Newfoundland, and Rottweiler. Genetic investigations seeking to identify causative mutations for SAS are lacking with only a single published variant associated with SAS in Newfoundlands. Article in Journal/Newspaper Newfoundland University of California: eScholarship Bouvier ENVELOPE(-68.133,-68.133,-67.233,-67.233) Flandres ENVELOPE(-63.417,-63.417,-65.033,-65.033) |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Aortic stenosis Cardiac genetics Congenital heart disease Subaortic stenosis Veterinary |
spellingShingle |
Aortic stenosis Cardiac genetics Congenital heart disease Subaortic stenosis Veterinary Ontiveros, Eric S Stern, Joshua A Genetics of canine subvalvular aortic stenosis (SAS). |
topic_facet |
Aortic stenosis Cardiac genetics Congenital heart disease Subaortic stenosis Veterinary |
description |
Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity. This review is focused on the prevalence, inheritance pattern, and current genetic insights of canine SAS. The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital. The mode of inheritance for this disease has also been described in breeds with a high disease prevalence such as the Bullmastiff, Bouvier des Flandres, Dogue de Bordeaux, Golden Retriever, Newfoundland, and Rottweiler. Genetic investigations seeking to identify causative mutations for SAS are lacking with only a single published variant associated with SAS in Newfoundlands. |
format |
Article in Journal/Newspaper |
author |
Ontiveros, Eric S Stern, Joshua A |
author_facet |
Ontiveros, Eric S Stern, Joshua A |
author_sort |
Ontiveros, Eric S |
title |
Genetics of canine subvalvular aortic stenosis (SAS). |
title_short |
Genetics of canine subvalvular aortic stenosis (SAS). |
title_full |
Genetics of canine subvalvular aortic stenosis (SAS). |
title_fullStr |
Genetics of canine subvalvular aortic stenosis (SAS). |
title_full_unstemmed |
Genetics of canine subvalvular aortic stenosis (SAS). |
title_sort |
genetics of canine subvalvular aortic stenosis (sas). |
publisher |
eScholarship, University of California |
publishDate |
2021 |
url |
https://escholarship.org/uc/item/2nr0m8z3 |
op_coverage |
4 |
long_lat |
ENVELOPE(-68.133,-68.133,-67.233,-67.233) ENVELOPE(-63.417,-63.417,-65.033,-65.033) |
geographic |
Bouvier Flandres |
geographic_facet |
Bouvier Flandres |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Canine medicine and genetics, vol 8, iss 1 |
op_relation |
qt2nr0m8z3 https://escholarship.org/uc/item/2nr0m8z3 |
op_rights |
public |
_version_ |
1766108583016005632 |