CO2-induced ocean acidification increases anxiety in rockfish via alteration of GABAA receptor functioning.
The average surface pH of the ocean is dropping at a rapid rate due to the dissolution of anthropogenic CO2, raising concerns for marine life. Additionally, some coastal areas periodically experience upwelling of CO2-enriched water with reduced pH. Previous research has demonstrated ocean acidificat...
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ftcdlib:oai:escholarship.org/ark:/13030/qt0vp448hj 2023-05-15T17:50:42+02:00 CO2-induced ocean acidification increases anxiety in rockfish via alteration of GABAA receptor functioning. Hamilton, Trevor James Holcombe, Adam Tresguerres, Martin 20132509 2014-01-22 application/pdf https://escholarship.org/uc/item/0vp448hj unknown eScholarship, University of California qt0vp448hj https://escholarship.org/uc/item/0vp448hj public Proceedings. Biological sciences, vol 281, iss 1775 Animals Perciformes Carbon Dioxide Muscimol Pyridazines Fish Proteins Receptors GABA-A GABA Antagonists Behavior Animal Anxiety Seawater Environmental Exposure Hydrogen-Ion Concentration Oceans and Seas GABA-A Receptor Agonists Sebastes gabazine upwelling Biological Sciences Medical and Health Sciences Agricultural and Veterinary Sciences article 2014 ftcdlib 2020-01-17T23:53:29Z The average surface pH of the ocean is dropping at a rapid rate due to the dissolution of anthropogenic CO2, raising concerns for marine life. Additionally, some coastal areas periodically experience upwelling of CO2-enriched water with reduced pH. Previous research has demonstrated ocean acidification (OA)-induced changes in behavioural and sensory systems including olfaction, which is due to altered function of neural gamma-aminobutyric acid type A (GABAA) receptors. Here, we used a camera-based tracking software system to examine whether OA-dependent changes in GABAA receptors affect anxiety in juvenile Californian rockfish (Sebastes diploproa). Anxiety was estimated using behavioural tests that measure light/dark preference (scototaxis) and proximity to an object. After one week in OA conditions projected for the next century in the California shore (1125 ± 100 µatm, pH 7.75), anxiety was significantly increased relative to controls (483 ± 40 µatm CO2, pH 8.1). The GABAA-receptor agonist muscimol, but not the antagonist gabazine, caused a significant increase in anxiety consistent with altered Cl(-) flux in OA-exposed fish. OA-exposed fish remained more anxious even after 7 days back in control seawater; however, they resumed their normal behaviour by day 12. These results show that OA could severely alter rockfish behaviour; however, this effect is reversible. Article in Journal/Newspaper Ocean acidification University of California: eScholarship |
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Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
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topic |
Animals Perciformes Carbon Dioxide Muscimol Pyridazines Fish Proteins Receptors GABA-A GABA Antagonists Behavior Animal Anxiety Seawater Environmental Exposure Hydrogen-Ion Concentration Oceans and Seas GABA-A Receptor Agonists Sebastes gabazine upwelling Biological Sciences Medical and Health Sciences Agricultural and Veterinary Sciences |
spellingShingle |
Animals Perciformes Carbon Dioxide Muscimol Pyridazines Fish Proteins Receptors GABA-A GABA Antagonists Behavior Animal Anxiety Seawater Environmental Exposure Hydrogen-Ion Concentration Oceans and Seas GABA-A Receptor Agonists Sebastes gabazine upwelling Biological Sciences Medical and Health Sciences Agricultural and Veterinary Sciences Hamilton, Trevor James Holcombe, Adam Tresguerres, Martin CO2-induced ocean acidification increases anxiety in rockfish via alteration of GABAA receptor functioning. |
topic_facet |
Animals Perciformes Carbon Dioxide Muscimol Pyridazines Fish Proteins Receptors GABA-A GABA Antagonists Behavior Animal Anxiety Seawater Environmental Exposure Hydrogen-Ion Concentration Oceans and Seas GABA-A Receptor Agonists Sebastes gabazine upwelling Biological Sciences Medical and Health Sciences Agricultural and Veterinary Sciences |
description |
The average surface pH of the ocean is dropping at a rapid rate due to the dissolution of anthropogenic CO2, raising concerns for marine life. Additionally, some coastal areas periodically experience upwelling of CO2-enriched water with reduced pH. Previous research has demonstrated ocean acidification (OA)-induced changes in behavioural and sensory systems including olfaction, which is due to altered function of neural gamma-aminobutyric acid type A (GABAA) receptors. Here, we used a camera-based tracking software system to examine whether OA-dependent changes in GABAA receptors affect anxiety in juvenile Californian rockfish (Sebastes diploproa). Anxiety was estimated using behavioural tests that measure light/dark preference (scototaxis) and proximity to an object. After one week in OA conditions projected for the next century in the California shore (1125 ± 100 µatm, pH 7.75), anxiety was significantly increased relative to controls (483 ± 40 µatm CO2, pH 8.1). The GABAA-receptor agonist muscimol, but not the antagonist gabazine, caused a significant increase in anxiety consistent with altered Cl(-) flux in OA-exposed fish. OA-exposed fish remained more anxious even after 7 days back in control seawater; however, they resumed their normal behaviour by day 12. These results show that OA could severely alter rockfish behaviour; however, this effect is reversible. |
format |
Article in Journal/Newspaper |
author |
Hamilton, Trevor James Holcombe, Adam Tresguerres, Martin |
author_facet |
Hamilton, Trevor James Holcombe, Adam Tresguerres, Martin |
author_sort |
Hamilton, Trevor James |
title |
CO2-induced ocean acidification increases anxiety in rockfish via alteration of GABAA receptor functioning. |
title_short |
CO2-induced ocean acidification increases anxiety in rockfish via alteration of GABAA receptor functioning. |
title_full |
CO2-induced ocean acidification increases anxiety in rockfish via alteration of GABAA receptor functioning. |
title_fullStr |
CO2-induced ocean acidification increases anxiety in rockfish via alteration of GABAA receptor functioning. |
title_full_unstemmed |
CO2-induced ocean acidification increases anxiety in rockfish via alteration of GABAA receptor functioning. |
title_sort |
co2-induced ocean acidification increases anxiety in rockfish via alteration of gabaa receptor functioning. |
publisher |
eScholarship, University of California |
publishDate |
2014 |
url |
https://escholarship.org/uc/item/0vp448hj |
op_coverage |
20132509 |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_source |
Proceedings. Biological sciences, vol 281, iss 1775 |
op_relation |
qt0vp448hj https://escholarship.org/uc/item/0vp448hj |
op_rights |
public |
_version_ |
1766157580960268288 |