A supergene determines highly divergent male reproductive morphs in the ruff.
Three strikingly different alternative male mating morphs (aggressive 'independents', semicooperative 'satellites' and female-mimic 'faeders') coexist as a balanced polymorphism in the ruff, Philomachus pugnax, a lek-breeding wading bird. Major differences in body size,...
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ftcdlib:oai:escholarship.org/ark:/13030/qt0q03r34z 2023-05-15T17:58:41+02:00 A supergene determines highly divergent male reproductive morphs in the ruff. Küpper, Clemens Stocks, Michael Risse, Judith E Dos Remedios, Natalie Farrell, Lindsay L McRae, Susan B Morgan, Tawna C Karlionova, Natalia Pinchuk, Pavel Verkuil, Yvonne I Kitaysky, Alexander S Wingfield, John C Piersma, Theunis Zeng, Kai Slate, Jon Blaxter, Mark Lank, David B Burke, Terry 79 - 83 2016-01-01 application/pdf https://escholarship.org/uc/item/0q03r34z unknown eScholarship, University of California qt0q03r34z https://escholarship.org/uc/item/0q03r34z public Nature genetics, vol 48, iss 1 Testis Animals Birds Steroids Chromosomal Proteins Non-Histone Reproduction Haplotypes Polymorphism Single Nucleotide Female Male Sexual Behavior Animal Genome-Wide Association Study Genetic Linkage Developmental Biology Biological Sciences Medical and Health Sciences article 2016 ftcdlib 2020-11-20T15:17:05Z Three strikingly different alternative male mating morphs (aggressive 'independents', semicooperative 'satellites' and female-mimic 'faeders') coexist as a balanced polymorphism in the ruff, Philomachus pugnax, a lek-breeding wading bird. Major differences in body size, ornamentation, and aggressive and mating behaviors are inherited as an autosomal polymorphism. We show that development into satellites and faeders is determined by a supergene consisting of divergent alternative, dominant and non-recombining haplotypes of an inversion on chromosome 11, which contains 125 predicted genes. Independents are homozygous for the ancestral sequence. One breakpoint of the inversion disrupts the essential CENP-N gene (encoding centromere protein N), and pedigree analysis confirms the lethality of homozygosity for the inversion. We describe new differences in behavior, testis size and steroid metabolism among morphs and identify polymorphic genes within the inversion that are likely to contribute to the differences among morphs in reproductive traits. Article in Journal/Newspaper Philomachus pugnax Ruff University of California: eScholarship |
institution |
Open Polar |
collection |
University of California: eScholarship |
op_collection_id |
ftcdlib |
language |
unknown |
topic |
Testis Animals Birds Steroids Chromosomal Proteins Non-Histone Reproduction Haplotypes Polymorphism Single Nucleotide Female Male Sexual Behavior Animal Genome-Wide Association Study Genetic Linkage Developmental Biology Biological Sciences Medical and Health Sciences |
spellingShingle |
Testis Animals Birds Steroids Chromosomal Proteins Non-Histone Reproduction Haplotypes Polymorphism Single Nucleotide Female Male Sexual Behavior Animal Genome-Wide Association Study Genetic Linkage Developmental Biology Biological Sciences Medical and Health Sciences Küpper, Clemens Stocks, Michael Risse, Judith E Dos Remedios, Natalie Farrell, Lindsay L McRae, Susan B Morgan, Tawna C Karlionova, Natalia Pinchuk, Pavel Verkuil, Yvonne I Kitaysky, Alexander S Wingfield, John C Piersma, Theunis Zeng, Kai Slate, Jon Blaxter, Mark Lank, David B Burke, Terry A supergene determines highly divergent male reproductive morphs in the ruff. |
topic_facet |
Testis Animals Birds Steroids Chromosomal Proteins Non-Histone Reproduction Haplotypes Polymorphism Single Nucleotide Female Male Sexual Behavior Animal Genome-Wide Association Study Genetic Linkage Developmental Biology Biological Sciences Medical and Health Sciences |
description |
Three strikingly different alternative male mating morphs (aggressive 'independents', semicooperative 'satellites' and female-mimic 'faeders') coexist as a balanced polymorphism in the ruff, Philomachus pugnax, a lek-breeding wading bird. Major differences in body size, ornamentation, and aggressive and mating behaviors are inherited as an autosomal polymorphism. We show that development into satellites and faeders is determined by a supergene consisting of divergent alternative, dominant and non-recombining haplotypes of an inversion on chromosome 11, which contains 125 predicted genes. Independents are homozygous for the ancestral sequence. One breakpoint of the inversion disrupts the essential CENP-N gene (encoding centromere protein N), and pedigree analysis confirms the lethality of homozygosity for the inversion. We describe new differences in behavior, testis size and steroid metabolism among morphs and identify polymorphic genes within the inversion that are likely to contribute to the differences among morphs in reproductive traits. |
format |
Article in Journal/Newspaper |
author |
Küpper, Clemens Stocks, Michael Risse, Judith E Dos Remedios, Natalie Farrell, Lindsay L McRae, Susan B Morgan, Tawna C Karlionova, Natalia Pinchuk, Pavel Verkuil, Yvonne I Kitaysky, Alexander S Wingfield, John C Piersma, Theunis Zeng, Kai Slate, Jon Blaxter, Mark Lank, David B Burke, Terry |
author_facet |
Küpper, Clemens Stocks, Michael Risse, Judith E Dos Remedios, Natalie Farrell, Lindsay L McRae, Susan B Morgan, Tawna C Karlionova, Natalia Pinchuk, Pavel Verkuil, Yvonne I Kitaysky, Alexander S Wingfield, John C Piersma, Theunis Zeng, Kai Slate, Jon Blaxter, Mark Lank, David B Burke, Terry |
author_sort |
Küpper, Clemens |
title |
A supergene determines highly divergent male reproductive morphs in the ruff. |
title_short |
A supergene determines highly divergent male reproductive morphs in the ruff. |
title_full |
A supergene determines highly divergent male reproductive morphs in the ruff. |
title_fullStr |
A supergene determines highly divergent male reproductive morphs in the ruff. |
title_full_unstemmed |
A supergene determines highly divergent male reproductive morphs in the ruff. |
title_sort |
supergene determines highly divergent male reproductive morphs in the ruff. |
publisher |
eScholarship, University of California |
publishDate |
2016 |
url |
https://escholarship.org/uc/item/0q03r34z |
op_coverage |
79 - 83 |
genre |
Philomachus pugnax Ruff |
genre_facet |
Philomachus pugnax Ruff |
op_source |
Nature genetics, vol 48, iss 1 |
op_relation |
qt0q03r34z https://escholarship.org/uc/item/0q03r34z |
op_rights |
public |
_version_ |
1766167371602460672 |