Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues
Passage of environmental chemicals across the placenta has important toxicological consequences, as well as for choosing samples for analysis and for interpreting the results. To obtain systematic data, we collected in 2000 maternal and cord blood, cord tissue, placenta, and milk in connection with...
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ftcdc:oai:example.org:cdc:3985 2023-05-15T16:10:59+02:00 Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues Environ Sci Technol Needham, Larry L. Grandjean, Philippe Heinzow, Birger Jørgensen, Poul J. Nielsen, Flemming Patterson, Donald G. Sjödin, Andreas Turner, Wayman E. Weihe, Pal http://stacks.cdc.gov/view/cdc/3985/ unknown http://stacks.cdc.gov/view/cdc/3985/ Environ Sci Technol. 2010; 45(3):1121-1126. Article Adult Alkanesulfonic Acids Caprylates Environmental Monitoring Environmental Pollutants Environmental Pollution Female Fetal Blood Fluorocarbons Hair Humans Maternal Exposure Maternal-Fetal Exchange Metals Heavy Milk Human Pesticides Placenta Polychlorinated Biphenyls Pregnancy Umbilical Cord Young Adult ftcdc 2017-04-11T13:07:22Z Passage of environmental chemicals across the placenta has important toxicological consequences, as well as for choosing samples for analysis and for interpreting the results. To obtain systematic data, we collected in 2000 maternal and cord blood, cord tissue, placenta, and milk in connection with births in the Faroe Islands, where exposures to marine contaminants is increased. In 15 sample sets, we measured a total of 87 environmental chemicals, almost all of which were detected both in maternal and fetal tissues. The maternal serum lipid-based concentrations of organohalogen compounds averaged 1.7 times those of cord serum, 2.8 times those of cord tissue and placenta, and 0.7 those of milk. For organohalogen compounds detectable in all matrices, a high degree of correlation between concentrations in maternal serum and the other tissues investigated was generally observed (r(2) > 0.5). Greater degree of chlorination resulted in lower transfer from maternal serum into milk. Concentrations of pentachlorbenzene, γ-hexachlorocyclohexane, and several polychlorinated biphenyl congeners with low chlorination were higher in fetal samples and showed poor correlation with maternal levels. Perfluorinated compounds occurred in lower concentrations in cord serum than in maternal serum. Cadmium, lead, mercury, and selenium were all detected in fetal samples, but only mercury showed close correlations among concentrations in different matrices. Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform. Other/Unknown Material Faroe Islands CDC Stacks (Centers for Disease Control and Prevention) Faroe Islands |
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Article Adult Alkanesulfonic Acids Caprylates Environmental Monitoring Environmental Pollutants Environmental Pollution Female Fetal Blood Fluorocarbons Hair Humans Maternal Exposure Maternal-Fetal Exchange Metals Heavy Milk Human Pesticides Placenta Polychlorinated Biphenyls Pregnancy Umbilical Cord Young Adult |
spellingShingle |
Article Adult Alkanesulfonic Acids Caprylates Environmental Monitoring Environmental Pollutants Environmental Pollution Female Fetal Blood Fluorocarbons Hair Humans Maternal Exposure Maternal-Fetal Exchange Metals Heavy Milk Human Pesticides Placenta Polychlorinated Biphenyls Pregnancy Umbilical Cord Young Adult Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues |
topic_facet |
Article Adult Alkanesulfonic Acids Caprylates Environmental Monitoring Environmental Pollutants Environmental Pollution Female Fetal Blood Fluorocarbons Hair Humans Maternal Exposure Maternal-Fetal Exchange Metals Heavy Milk Human Pesticides Placenta Polychlorinated Biphenyls Pregnancy Umbilical Cord Young Adult |
description |
Passage of environmental chemicals across the placenta has important toxicological consequences, as well as for choosing samples for analysis and for interpreting the results. To obtain systematic data, we collected in 2000 maternal and cord blood, cord tissue, placenta, and milk in connection with births in the Faroe Islands, where exposures to marine contaminants is increased. In 15 sample sets, we measured a total of 87 environmental chemicals, almost all of which were detected both in maternal and fetal tissues. The maternal serum lipid-based concentrations of organohalogen compounds averaged 1.7 times those of cord serum, 2.8 times those of cord tissue and placenta, and 0.7 those of milk. For organohalogen compounds detectable in all matrices, a high degree of correlation between concentrations in maternal serum and the other tissues investigated was generally observed (r(2) > 0.5). Greater degree of chlorination resulted in lower transfer from maternal serum into milk. Concentrations of pentachlorbenzene, γ-hexachlorocyclohexane, and several polychlorinated biphenyl congeners with low chlorination were higher in fetal samples and showed poor correlation with maternal levels. Perfluorinated compounds occurred in lower concentrations in cord serum than in maternal serum. Cadmium, lead, mercury, and selenium were all detected in fetal samples, but only mercury showed close correlations among concentrations in different matrices. Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform. |
author2 |
Needham, Larry L. Grandjean, Philippe Heinzow, Birger Jørgensen, Poul J. Nielsen, Flemming Patterson, Donald G. Sjödin, Andreas Turner, Wayman E. Weihe, Pal |
title |
Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues |
title_short |
Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues |
title_full |
Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues |
title_fullStr |
Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues |
title_full_unstemmed |
Partition of Environmental Chemicals between Maternal and Fetal Blood and Tissues |
title_sort |
partition of environmental chemicals between maternal and fetal blood and tissues |
url |
http://stacks.cdc.gov/view/cdc/3985/ |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Environ Sci Technol. 2010; 45(3):1121-1126. |
op_relation |
http://stacks.cdc.gov/view/cdc/3985/ |
_version_ |
1765996115473203200 |