The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults
Background Helicobacter pylori (H. pylori) infection has been correlated with low serum ferritin and iron deficiency. As a secondary analysis of a study of H. pylori reinfection, we investigated the association of H. pylori infection and the effect of its eradication on serum ferritin and iron defic...
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ftcdc:oai:example.org:cdc:34201 2023-05-15T16:55:30+02:00 The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults Helicobacter Miernyk, Karen Bruden, Dana Zanis, Carolyn McMahon, Brian Sacco, Frank Hennessy, Thomas Parkinson, Alan Bruce, Michael http://stacks.cdc.gov/view/cdc/34201/ unknown http://stacks.cdc.gov/view/cdc/34201/ Helicobacter. 18(3):222-228. Article Adult Alaska Anemia Iron-Deficiency Anti-Bacterial Agents Female Ferritins Helicobacter Infections Helicobacter pylori Humans Indians North American Inuits Iron Male Middle Aged Urban Population ftcdc 2017-04-11T13:31:32Z Background Helicobacter pylori (H. pylori) infection has been correlated with low serum ferritin and iron deficiency. As a secondary analysis of a study of H. pylori reinfection, we investigated the association of H. pylori infection and the effect of its eradication on serum ferritin and iron deficiency. Methods Alaska Native adults undergoing esophagogastroduodenoscopy had sera collected and a 13C urea breath test (UBT) performed. Those H. pylori positive were treated with an antibiotic regimen; those who tested negative 2 months after treatment were evaluated at 4, 6, 12, and 24 months by UBT and serum ferritin with an immunoradiometric assay. We excluded persons from further analysis if they were prescribed iron by their provider. Results We measured serum ferritin for 241 persons; 121/241 were H. pylori positive. The geometric mean ferritin (GMF) for persons with and without H. pylori infection were 37 µg/L and 50 µg/L, respectively (p=0.04). At enrollment, 19/121 H. pylori-positive persons had iron deficiency compared with 8/120 H. pylori negative (p=0.02). Among 66 persons tested at 24 months, the GMF was higher at 24 months (49.6 µg/L) versus enrollment (36.5 µg/L; p=0.02). Six of 11 persons with iron deficiency at enrollment no longer had iron deficiency and had a higher GMF (p=0.02) 24 months after treatment. Conclusions H. pylori infection was correlated with lower serum ferritin and iron deficiency. After H. pylori eradication, serum ferritin increased and approximately half of persons resolved their iron deficiency. Testing for H. pylori infection and subsequent treatment of those positive could be considered in persons with unexplained iron deficiency. KCM4/Intramural CDC HHS/United States 2015-09-10T00:00:00Z 23316928 PMC4565132 Other/Unknown Material inuits Alaska CDC Stacks (Centers for Disease Control and Prevention) |
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Article Adult Alaska Anemia Iron-Deficiency Anti-Bacterial Agents Female Ferritins Helicobacter Infections Helicobacter pylori Humans Indians North American Inuits Iron Male Middle Aged Urban Population |
spellingShingle |
Article Adult Alaska Anemia Iron-Deficiency Anti-Bacterial Agents Female Ferritins Helicobacter Infections Helicobacter pylori Humans Indians North American Inuits Iron Male Middle Aged Urban Population The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults |
topic_facet |
Article Adult Alaska Anemia Iron-Deficiency Anti-Bacterial Agents Female Ferritins Helicobacter Infections Helicobacter pylori Humans Indians North American Inuits Iron Male Middle Aged Urban Population |
description |
Background Helicobacter pylori (H. pylori) infection has been correlated with low serum ferritin and iron deficiency. As a secondary analysis of a study of H. pylori reinfection, we investigated the association of H. pylori infection and the effect of its eradication on serum ferritin and iron deficiency. Methods Alaska Native adults undergoing esophagogastroduodenoscopy had sera collected and a 13C urea breath test (UBT) performed. Those H. pylori positive were treated with an antibiotic regimen; those who tested negative 2 months after treatment were evaluated at 4, 6, 12, and 24 months by UBT and serum ferritin with an immunoradiometric assay. We excluded persons from further analysis if they were prescribed iron by their provider. Results We measured serum ferritin for 241 persons; 121/241 were H. pylori positive. The geometric mean ferritin (GMF) for persons with and without H. pylori infection were 37 µg/L and 50 µg/L, respectively (p=0.04). At enrollment, 19/121 H. pylori-positive persons had iron deficiency compared with 8/120 H. pylori negative (p=0.02). Among 66 persons tested at 24 months, the GMF was higher at 24 months (49.6 µg/L) versus enrollment (36.5 µg/L; p=0.02). Six of 11 persons with iron deficiency at enrollment no longer had iron deficiency and had a higher GMF (p=0.02) 24 months after treatment. Conclusions H. pylori infection was correlated with lower serum ferritin and iron deficiency. After H. pylori eradication, serum ferritin increased and approximately half of persons resolved their iron deficiency. Testing for H. pylori infection and subsequent treatment of those positive could be considered in persons with unexplained iron deficiency. KCM4/Intramural CDC HHS/United States 2015-09-10T00:00:00Z 23316928 PMC4565132 |
author2 |
Miernyk, Karen Bruden, Dana Zanis, Carolyn McMahon, Brian Sacco, Frank Hennessy, Thomas Parkinson, Alan Bruce, Michael |
title |
The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults |
title_short |
The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults |
title_full |
The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults |
title_fullStr |
The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults |
title_full_unstemmed |
The effect of Helicobacter pylori infection on iron stores and iron deficiency in urban Alaska Native adults |
title_sort |
effect of helicobacter pylori infection on iron stores and iron deficiency in urban alaska native adults |
url |
http://stacks.cdc.gov/view/cdc/34201/ |
genre |
inuits Alaska |
genre_facet |
inuits Alaska |
op_source |
Helicobacter. 18(3):222-228. |
op_relation |
http://stacks.cdc.gov/view/cdc/34201/ |
_version_ |
1766046490409566208 |