Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean.

• Published in: Journal of General Virology
• Main Authors: Filippone, Claudia, Castel, Guillaume, Murri, Séverine, Beaulieux, Frédérik, Ermonval, Myriam, Jallet, Corinne, Wise, Emma L, Ellis, Richard J, Marston, Denise A, McElhinney, Lorraine M, Fooks, Anthony R, Desvars, Amélie, Halos, Lénaı G, Vourc'h, Gwenaël, Marianneau, Philippe, Tordo, Noël
• Other Authors: Stratégies antivirales, Institut Pasteur Paris, Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD France-Sud )-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Laboratoire de Lyon ANSES, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Hôpital de la Croix-Rousse CHU - HCL, Hospices Civils de Lyon (HCL), Centre de Recherche Clinique Lyon, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Wildlife Zoonoses and Vector-borne Diseases Research Group, Animal Health and Veterinary Laboratories Agency (AHVLA), University of Liverpool, Unité de Recherche d'Épidémiologie Animale (UR EpiA), Institut National de la Recherche Agronomique (INRA), Mérial Lyon, Mérial, This study was supported by the EU FP7 programmes: EDENext (no. 261504), EMPERIE (no. 223498), ANTIGONE (no. 278976) and the Research Infrastructure Grant European Virus Archive (no. 19 228292). We thank Sandra Lacote (Virology Unit, Anses-Laboratoire, Lyon, France) for helping during RNA extraction. A. R. F. was supported by the Research and Policy for Infectious Disease Dynamics Program (RAPIDD), Science and Technology Directorate, US Department of Homeland Security and Fogarty International Center, US National Institutes of Health. Sampling was supported by the French Research National Agency ChikAni (ANR no. 06SEST06)., European Project: 261504,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,EDENEXT(2011), European Project: 223498,EC:FP7:HEALTH,FP7-HEALTH-2007-B,EMPERIE(2009), European Project: 278976,EC:FP7:HEALTH,FP7-HEALTH-2011-two-stage,ANTIGONE(2011), European Project: 228292,EC:FP7:INFRA,FP7-INFRASTRUCTURES-2008-1,EVA(2009)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2016
• Subjects: [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; Indian; Rattus rattus
• Online Access: https://hal-pasteur.archives-ouvertes.fr/pasteur-01350075; https://hal-pasteur.archives-ouvertes.fr/pasteur-01350075/document; https://hal-pasteur.archives-ouvertes.fr/pasteur-01350075/file/JGV-2016.pdf; https://doi.org/10.1099/jgv.0.000440

International audience Hantaviruses are emerging zoonotic viruses that cause human diseases. In this study, sera from 642 mammals from La Réunion and Mayotte islands (Indian Ocean) were screened for the presence of hantaviruses by molecular analysis. None of the mammals from La Réunion island was positive, but hantavirus genomic RNA was discovered in 29/160 (18 %) Rattus rattus from Mayotte island. The nucleoprotein coding region was sequenced from the liver and spleen of all positive individuals allowing epidemiological and intra-strain variability analyses. Phylogenetic analysis based on complete coding genomic sequences showed that this Murinae-associated hantavirus is a new variant of Thailand virus. Further studies are needed to investigate hantaviruses in rodent hosts and in Haemorrhagic Fever with Renal Syndrome (HFRS) human cases.