A Secondary Sialic Acid Binding Site on Influenza Virus Neuraminidase: Fact or Fiction?

• Published in: Angewandte Chemie International Edition
• Main Authors: Lai, Jimmy C. C., Garcia, Jean-Michel, Dyason, Jeffrey C., Böhm, Raphael, Madge, Paul D., Rose, Faith J., Nicholls, John M., Peiris, J. S. Malik, Haselhorst, Thomas, Von Itzstein, Mark
• Other Authors: Centre de recherche Université de Hong-Kong-Pasteur, Réseau International des Instituts Pasteur (RIIP), Institute for Glycomics, Griffith University Brisbane, Department of pathology HKU, The University of Hong Kong (HKU)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2012
• Subjects: [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; Avian flu
• Online Access: https://hal-riip.archives-ouvertes.fr/pasteur-00664159; https://doi.org/10.1002/anie.201108245

International audience One flu over the cuckoo's nest: The biological significance of a secondary sialic acid binding site on influenza virus neuraminidase remains elusive. On blocking the active site influenza-virus-containing virus-like particles with oseltamivir carboxylate, binding to α(2,3)-sialyllactose is still detected. Thus the sialyllactose must bind at a secondary sialic acid binding site (see structures: docking study of α(2,3)-sialyllactose in the secondary binding site of avian flu neuraminidase).