Innovative In Silico Approaches to Address Avian Flu Using Grid Technology
The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viru...
Main Authors: | , , , , , , , , , , |
---|---|
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2009
|
Subjects: | |
Online Access: | http://hal.in2p3.fr/in2p3-00441054 |
id |
ftccsdartic:oai:HAL:in2p3-00441054v1 |
---|---|
record_format |
openpolar |
spelling |
ftccsdartic:oai:HAL:in2p3-00441054v1 2023-05-15T15:34:10+02:00 Innovative In Silico Approaches to Address Avian Flu Using Grid Technology BRETON, Vincent Da Costa, L.A. De Vlieger, Paul Kim, Y.-M. Maigne, L. Reuillon, Romain Sarramia, D. H.A.I. Truong, N. Q. U.A.N.G. Nguyen, H. Kim, D. Wu, Y.-T. Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC) Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) 2009 http://hal.in2p3.fr/in2p3-00441054 en eng HAL CCSD in2p3-00441054 http://hal.in2p3.fr/in2p3-00441054 Infectious disorders drug targets http://hal.in2p3.fr/in2p3-00441054 Infectious disorders drug targets, 2009, 9, pp.358-365 Avian flu grid surveillance network virtual screening molecular epidemiology [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] info:eu-repo/semantics/article Journal articles 2009 ftccsdartic 2021-12-19T03:57:03Z The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper proposes new approaches for the integration of existing data sources towards a global surveillance network for molecular epidemiology and in silico drug discovery. Article in Journal/Newspaper Avian flu Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
Avian flu grid surveillance network virtual screening molecular epidemiology [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] |
spellingShingle |
Avian flu grid surveillance network virtual screening molecular epidemiology [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] BRETON, Vincent Da Costa, L.A. De Vlieger, Paul Kim, Y.-M. Maigne, L. Reuillon, Romain Sarramia, D. H.A.I. Truong, N. Q. U.A.N.G. Nguyen, H. Kim, D. Wu, Y.-T. Innovative In Silico Approaches to Address Avian Flu Using Grid Technology |
topic_facet |
Avian flu grid surveillance network virtual screening molecular epidemiology [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] |
description |
The recent years have seen the emergence of diseases which have spread very quickly all around the world either through human travels like SARS or animal migration like avian flu. Among the biggest challenges raised by infectious emerging diseases, one is related to the constant mutation of the viruses which turns them into continuously moving targets for drug and vaccine discovery. Another challenge is related to the early detection and surveillance of the diseases as new cases can appear just anywhere due to the globalization of exchanges and the circulation of people and animals around the earth, as recently demonstrated by the avian flu epidemics. For 3 years now, a collaboration of teams in Europe and Asia has been exploring some innovative in silico approaches to better tackle avian flu taking advantage of the very large computing resources available on international grid infrastructures. Grids were used to study the impact of mutations on the effectiveness of existing drugs against H5N1 and to find potentially new leads active on mutated strains. Grids allow also the integration of distributed data in a completely secured way. The paper proposes new approaches for the integration of existing data sources towards a global surveillance network for molecular epidemiology and in silico drug discovery. |
author2 |
Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC) Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) |
format |
Article in Journal/Newspaper |
author |
BRETON, Vincent Da Costa, L.A. De Vlieger, Paul Kim, Y.-M. Maigne, L. Reuillon, Romain Sarramia, D. H.A.I. Truong, N. Q. U.A.N.G. Nguyen, H. Kim, D. Wu, Y.-T. |
author_facet |
BRETON, Vincent Da Costa, L.A. De Vlieger, Paul Kim, Y.-M. Maigne, L. Reuillon, Romain Sarramia, D. H.A.I. Truong, N. Q. U.A.N.G. Nguyen, H. Kim, D. Wu, Y.-T. |
author_sort |
BRETON, Vincent |
title |
Innovative In Silico Approaches to Address Avian Flu Using Grid Technology |
title_short |
Innovative In Silico Approaches to Address Avian Flu Using Grid Technology |
title_full |
Innovative In Silico Approaches to Address Avian Flu Using Grid Technology |
title_fullStr |
Innovative In Silico Approaches to Address Avian Flu Using Grid Technology |
title_full_unstemmed |
Innovative In Silico Approaches to Address Avian Flu Using Grid Technology |
title_sort |
innovative in silico approaches to address avian flu using grid technology |
publisher |
HAL CCSD |
publishDate |
2009 |
url |
http://hal.in2p3.fr/in2p3-00441054 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
Infectious disorders drug targets http://hal.in2p3.fr/in2p3-00441054 Infectious disorders drug targets, 2009, 9, pp.358-365 |
op_relation |
in2p3-00441054 http://hal.in2p3.fr/in2p3-00441054 |
_version_ |
1766364667661254656 |