Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes
International audience Antibiotic consumption and its abuses have been historically and repeatedly pointed out as the major driver of antibiotic resistance emergence and propagation. However, several examples show that resistance may persist despite substantial reductions in antibiotic use, and that...
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ftccsdartic:oai:HAL:hal-04301598v1 2024-01-21T09:59:17+01:00 Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes Pradier, Léa Bedhomme, Stéphanie Centre d’Ecologie Fonctionnelle et Evolutive (CEFE) Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE) Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD France-Sud )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM) 2023-02-14 https://hal.science/hal-04301598 https://doi.org/10.7554/eLife.77015 en eng HAL CCSD eLife Sciences Publication info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.77015 hal-04301598 https://hal.science/hal-04301598 doi:10.7554/eLife.77015 EISSN: 2050-084X eLife https://hal.science/hal-04301598 eLife, 2023, 12, ⟨10.7554/eLife.77015⟩ [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2023 ftccsdartic https://doi.org/10.7554/eLife.77015 2023-12-23T23:33:25Z International audience Antibiotic consumption and its abuses have been historically and repeatedly pointed out as the major driver of antibiotic resistance emergence and propagation. However, several examples show that resistance may persist despite substantial reductions in antibiotic use, and that other factors are at stake. Here, we study the temporal, spatial, and ecological distribution patterns of aminoglycoside resistance, by screening more than 160,000 publicly available genomes for 27 clusters of genes encoding aminoglycoside-modifying enzymes (AME genes). We find that AME genes display a very ubiquitous pattern: about 25% of sequenced bacteria carry AME genes. These bacteria were sequenced from all the continents (except Antarctica) and terrestrial biomes, and belong to a wide number of phyla. By focusing on European countries between 1997 and 2018, we show that aminoglycoside consumption has little impact on the prevalence of AME-gene-carrying bacteria, whereas most variation in prevalence is observed among biomes. We further analyze the resemblance of resistome compositions across biomes: soil, wildlife, and human samples appear to be central to understand the exchanges of AME genes between different ecological contexts. Together, these results support the idea that interventional strategies based on reducing antibiotic use should be complemented by a stronger control of exchanges, especially between ecosystems. Article in Journal/Newspaper Antarc* Antarctica Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) eLife 12 |
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Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
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[SDV]Life Sciences [q-bio] |
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[SDV]Life Sciences [q-bio] Pradier, Léa Bedhomme, Stéphanie Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes |
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[SDV]Life Sciences [q-bio] |
description |
International audience Antibiotic consumption and its abuses have been historically and repeatedly pointed out as the major driver of antibiotic resistance emergence and propagation. However, several examples show that resistance may persist despite substantial reductions in antibiotic use, and that other factors are at stake. Here, we study the temporal, spatial, and ecological distribution patterns of aminoglycoside resistance, by screening more than 160,000 publicly available genomes for 27 clusters of genes encoding aminoglycoside-modifying enzymes (AME genes). We find that AME genes display a very ubiquitous pattern: about 25% of sequenced bacteria carry AME genes. These bacteria were sequenced from all the continents (except Antarctica) and terrestrial biomes, and belong to a wide number of phyla. By focusing on European countries between 1997 and 2018, we show that aminoglycoside consumption has little impact on the prevalence of AME-gene-carrying bacteria, whereas most variation in prevalence is observed among biomes. We further analyze the resemblance of resistome compositions across biomes: soil, wildlife, and human samples appear to be central to understand the exchanges of AME genes between different ecological contexts. Together, these results support the idea that interventional strategies based on reducing antibiotic use should be complemented by a stronger control of exchanges, especially between ecosystems. |
author2 |
Centre d’Ecologie Fonctionnelle et Evolutive (CEFE) Université Paul-Valéry - Montpellier 3 (UPVM)-École Pratique des Hautes Études (EPHE) Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD France-Sud )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM) |
format |
Article in Journal/Newspaper |
author |
Pradier, Léa Bedhomme, Stéphanie |
author_facet |
Pradier, Léa Bedhomme, Stéphanie |
author_sort |
Pradier, Léa |
title |
Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes |
title_short |
Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes |
title_full |
Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes |
title_fullStr |
Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes |
title_full_unstemmed |
Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes |
title_sort |
ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes |
publisher |
HAL CCSD |
publishDate |
2023 |
url |
https://hal.science/hal-04301598 https://doi.org/10.7554/eLife.77015 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
EISSN: 2050-084X eLife https://hal.science/hal-04301598 eLife, 2023, 12, ⟨10.7554/eLife.77015⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.7554/eLife.77015 hal-04301598 https://hal.science/hal-04301598 doi:10.7554/eLife.77015 |
op_doi |
https://doi.org/10.7554/eLife.77015 |
container_title |
eLife |
container_volume |
12 |
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1788695134896914432 |