Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age
Dietary exposure to trans-fatty acids (TFA) is likely to be high among Canadian Inuit; yet no data are available on the physiological effects of TFA in this population. The purpose of the present study was to assess the association between TFA and plasma lipid profiles in Inuit men and women living...
Published in: | British Journal of Nutrition |
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Online Access: | https://hal.science/hal-04265791 https://doi.org/10.1017/S0007114509297182 |
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ftccsdartic:oai:HAL:hal-04265791v1 2023-12-03T10:25:06+01:00 Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age Counil, Emilie Julien, Pierre Lamarche, Benoît Chateau-Degat, Marie-Ludivine Ferland, Annie Dewailly, Eric Université Laval Québec (ULaval) 2009-09-01 https://hal.science/hal-04265791 https://doi.org/10.1017/S0007114509297182 en eng HAL CCSD info:eu-repo/semantics/altIdentifier/doi/10.1017/S0007114509297182 hal-04265791 https://hal.science/hal-04265791 doi:10.1017/S0007114509297182 ISSN: 0007-1145 EISSN: 0007-1145 British Journal of Nutrition https://hal.science/hal-04265791 British Journal of Nutrition, 2009, 102 (5), pp.766-776. ⟨10.1017/S0007114509297182⟩ https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/association-between-transfatty-acids-in-erythrocytes-and-proatherogenic-lipid-profiles-among-canadian-inuit-of-nunavik-possible-influences-of-sex-and-age/93087B31DF3F2BC5DD95B0DC69CBC6B7 Cholesterol Diet Hydrogenated fat Lipoproteins Trans-fatty acids Health Inuit Canada Feeding Age Sex Quebec [SHS]Humanities and Social Sciences [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie info:eu-repo/semantics/article Journal articles 2009 ftccsdartic https://doi.org/10.1017/S0007114509297182 2023-11-04T23:29:02Z Dietary exposure to trans-fatty acids (TFA) is likely to be high among Canadian Inuit; yet no data are available on the physiological effects of TFA in this population. The purpose of the present study was to assess the association between TFA and plasma lipid profiles in Inuit men and women living in Nunavik (Québec, Canada). In a cross-sectional, population-based survey, a total of 795 Nunavik Inuit eligible participants gave a blood sample. Exposure to TFA was assessed by their relative proportion in erythrocyte membrane. We performed multiple regression analysis using plasma lipids or their linear combinations as the dependent variables and TFA as the main predictor, adjusting for potential confounders. The associations varied markedly between the sexes and according to age. In men (n 357, aged 36·3 (sd 14·3) years, TFA 1·24 (sd 0·54) %), TFA tended to be negatively associated with HDL-cholesterol (HDL-C), apoA1 and LDL particle size, and positively associated with non-HDL-C, LDL-cholesterol (LDL-C), apoB100, the apoB100:apoA1 ratio and the ratios of total cholesterol (TC), LDL-C and TAG to HDL-C. No such trends were observed in women (n 438, aged 37·0 (sd 14·1) years, TFA 1·16 (sd 0·54) %), except for HDL-C and apoA1 in women aged 50 years and more. These results suggest that TFA could raise the risk of CHD in Inuit men at least through their physiological effects on plasma lipids. The differential associations reported in pre- and postmenopausal women need to be reproduced in other populations and in experimental studies addressing the influence of sex hormones in response to dietary fats. Article in Journal/Newspaper inuit Nunavik Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Nunavik Canada British Journal of Nutrition 102 5 766 776 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
Cholesterol Diet Hydrogenated fat Lipoproteins Trans-fatty acids Health Inuit Canada Feeding Age Sex Quebec [SHS]Humanities and Social Sciences [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
spellingShingle |
Cholesterol Diet Hydrogenated fat Lipoproteins Trans-fatty acids Health Inuit Canada Feeding Age Sex Quebec [SHS]Humanities and Social Sciences [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Counil, Emilie Julien, Pierre Lamarche, Benoît Chateau-Degat, Marie-Ludivine Ferland, Annie Dewailly, Eric Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
topic_facet |
Cholesterol Diet Hydrogenated fat Lipoproteins Trans-fatty acids Health Inuit Canada Feeding Age Sex Quebec [SHS]Humanities and Social Sciences [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
description |
Dietary exposure to trans-fatty acids (TFA) is likely to be high among Canadian Inuit; yet no data are available on the physiological effects of TFA in this population. The purpose of the present study was to assess the association between TFA and plasma lipid profiles in Inuit men and women living in Nunavik (Québec, Canada). In a cross-sectional, population-based survey, a total of 795 Nunavik Inuit eligible participants gave a blood sample. Exposure to TFA was assessed by their relative proportion in erythrocyte membrane. We performed multiple regression analysis using plasma lipids or their linear combinations as the dependent variables and TFA as the main predictor, adjusting for potential confounders. The associations varied markedly between the sexes and according to age. In men (n 357, aged 36·3 (sd 14·3) years, TFA 1·24 (sd 0·54) %), TFA tended to be negatively associated with HDL-cholesterol (HDL-C), apoA1 and LDL particle size, and positively associated with non-HDL-C, LDL-cholesterol (LDL-C), apoB100, the apoB100:apoA1 ratio and the ratios of total cholesterol (TC), LDL-C and TAG to HDL-C. No such trends were observed in women (n 438, aged 37·0 (sd 14·1) years, TFA 1·16 (sd 0·54) %), except for HDL-C and apoA1 in women aged 50 years and more. These results suggest that TFA could raise the risk of CHD in Inuit men at least through their physiological effects on plasma lipids. The differential associations reported in pre- and postmenopausal women need to be reproduced in other populations and in experimental studies addressing the influence of sex hormones in response to dietary fats. |
author2 |
Université Laval Québec (ULaval) |
format |
Article in Journal/Newspaper |
author |
Counil, Emilie Julien, Pierre Lamarche, Benoît Chateau-Degat, Marie-Ludivine Ferland, Annie Dewailly, Eric |
author_facet |
Counil, Emilie Julien, Pierre Lamarche, Benoît Chateau-Degat, Marie-Ludivine Ferland, Annie Dewailly, Eric |
author_sort |
Counil, Emilie |
title |
Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_short |
Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_full |
Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_fullStr |
Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_full_unstemmed |
Association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among Canadian Inuit of Nunavik: possible influences of sex and age |
title_sort |
association between trans-fatty acids in erythrocytes and pro-atherogenic lipid profiles among canadian inuit of nunavik: possible influences of sex and age |
publisher |
HAL CCSD |
publishDate |
2009 |
url |
https://hal.science/hal-04265791 https://doi.org/10.1017/S0007114509297182 |
geographic |
Nunavik Canada |
geographic_facet |
Nunavik Canada |
genre |
inuit Nunavik |
genre_facet |
inuit Nunavik |
op_source |
ISSN: 0007-1145 EISSN: 0007-1145 British Journal of Nutrition https://hal.science/hal-04265791 British Journal of Nutrition, 2009, 102 (5), pp.766-776. ⟨10.1017/S0007114509297182⟩ https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/association-between-transfatty-acids-in-erythrocytes-and-proatherogenic-lipid-profiles-among-canadian-inuit-of-nunavik-possible-influences-of-sex-and-age/93087B31DF3F2BC5DD95B0DC69CBC6B7 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1017/S0007114509297182 hal-04265791 https://hal.science/hal-04265791 doi:10.1017/S0007114509297182 |
op_doi |
https://doi.org/10.1017/S0007114509297182 |
container_title |
British Journal of Nutrition |
container_volume |
102 |
container_issue |
5 |
container_start_page |
766 |
op_container_end_page |
776 |
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1784273793209860096 |