Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos
International audience Peptaibols are known membrane-modifying peptides that were recently detected in marine sediments and mussels collected from a shellfish farming area (Fier d'Ars, Atlantic coast, France). In this investigation, embryotoxicity bioassays with oysters (Crassostrea gigas) were...
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Online Access: | https://hal-nantes-universite.archives-ouvertes.fr/hal-03596297 https://doi.org/10.1016/j.aquatox.2007.04.009 |
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ftccsdartic:oai:HAL:hal-03596297v1 2023-05-15T15:57:57+02:00 Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos Poirier, Laurence Quiniou, Françoise Ruiz, Nicolas Montagu, Monique Amiard, Jean-Claude Pouchus, Yves François Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques Université de Nantes (UN) Biogéochimie et Ecotoxicologie (BE) Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) 2007-08 https://hal-nantes-universite.archives-ouvertes.fr/hal-03596297 https://doi.org/10.1016/j.aquatox.2007.04.009 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aquatox.2007.04.009 hal-03596297 https://hal-nantes-universite.archives-ouvertes.fr/hal-03596297 doi:10.1016/j.aquatox.2007.04.009 ISSN: 0166-445X Aquatic Toxicology https://hal-nantes-universite.archives-ouvertes.fr/hal-03596297 Aquatic Toxicology, Elsevier, 2007, 83 (4), pp.254-262. ⟨10.1016/j.aquatox.2007.04.009⟩ Risk assessment Embryotoxicity Bivalve bioassay Mycotoxins Marine fungi [SDE]Environmental Sciences [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2007 ftccsdartic https://doi.org/10.1016/j.aquatox.2007.04.009 2022-05-14T22:27:24Z International audience Peptaibols are known membrane-modifying peptides that were recently detected in marine sediments and mussels collected from a shellfish farming area (Fier d'Ars, Atlantic coast, France). In this investigation, embryotoxicity bioassays with oysters (Crassostrea gigas) were performed to assess acute toxicity of alamethicin and different groups of peptaibols produced by a Trichoderma longibrachiatum strain isolated from marine environment. C. gigas embryos appeared very sensitive to all the metabolites examined with higher toxic effects for long-sequence peptides (EC 50 ranging from 10 to 64 nM). D-shaped larvae with mantle abnormality were particularly noticed when peptaibol concentrations increased. Disturbances of embryogenesis were also observed following exposure to organic and aqueous extract of sediments from Fier d'Ars (EC 50 = 42.4 and 6.6 g L −1 dry weight, respectively). Although peptaibol concentrations measured in these sediments could explain only a part of the toxic effects observed, this study suggests that these mycotoxins can induce larval abnormalities in a population of exposed animals at environmentally realistic concentrations. Their detection in coastal areas devoted to bivalve culture should be taken into account. Article in Journal/Newspaper Crassostrea gigas Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Aquatic Toxicology 83 4 254 262 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
Risk assessment Embryotoxicity Bivalve bioassay Mycotoxins Marine fungi [SDE]Environmental Sciences [SDV]Life Sciences [q-bio] |
spellingShingle |
Risk assessment Embryotoxicity Bivalve bioassay Mycotoxins Marine fungi [SDE]Environmental Sciences [SDV]Life Sciences [q-bio] Poirier, Laurence Quiniou, Françoise Ruiz, Nicolas Montagu, Monique Amiard, Jean-Claude Pouchus, Yves François Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos |
topic_facet |
Risk assessment Embryotoxicity Bivalve bioassay Mycotoxins Marine fungi [SDE]Environmental Sciences [SDV]Life Sciences [q-bio] |
description |
International audience Peptaibols are known membrane-modifying peptides that were recently detected in marine sediments and mussels collected from a shellfish farming area (Fier d'Ars, Atlantic coast, France). In this investigation, embryotoxicity bioassays with oysters (Crassostrea gigas) were performed to assess acute toxicity of alamethicin and different groups of peptaibols produced by a Trichoderma longibrachiatum strain isolated from marine environment. C. gigas embryos appeared very sensitive to all the metabolites examined with higher toxic effects for long-sequence peptides (EC 50 ranging from 10 to 64 nM). D-shaped larvae with mantle abnormality were particularly noticed when peptaibol concentrations increased. Disturbances of embryogenesis were also observed following exposure to organic and aqueous extract of sediments from Fier d'Ars (EC 50 = 42.4 and 6.6 g L −1 dry weight, respectively). Although peptaibol concentrations measured in these sediments could explain only a part of the toxic effects observed, this study suggests that these mycotoxins can induce larval abnormalities in a population of exposed animals at environmentally realistic concentrations. Their detection in coastal areas devoted to bivalve culture should be taken into account. |
author2 |
Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques Université de Nantes (UN) Biogéochimie et Ecotoxicologie (BE) Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) |
format |
Article in Journal/Newspaper |
author |
Poirier, Laurence Quiniou, Françoise Ruiz, Nicolas Montagu, Monique Amiard, Jean-Claude Pouchus, Yves François |
author_facet |
Poirier, Laurence Quiniou, Françoise Ruiz, Nicolas Montagu, Monique Amiard, Jean-Claude Pouchus, Yves François |
author_sort |
Poirier, Laurence |
title |
Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos |
title_short |
Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos |
title_full |
Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos |
title_fullStr |
Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos |
title_full_unstemmed |
Toxicity assessment of peptaibols and contaminated sediments on Crassostrea gigas embryos |
title_sort |
toxicity assessment of peptaibols and contaminated sediments on crassostrea gigas embryos |
publisher |
HAL CCSD |
publishDate |
2007 |
url |
https://hal-nantes-universite.archives-ouvertes.fr/hal-03596297 https://doi.org/10.1016/j.aquatox.2007.04.009 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
ISSN: 0166-445X Aquatic Toxicology https://hal-nantes-universite.archives-ouvertes.fr/hal-03596297 Aquatic Toxicology, Elsevier, 2007, 83 (4), pp.254-262. ⟨10.1016/j.aquatox.2007.04.009⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.aquatox.2007.04.009 hal-03596297 https://hal-nantes-universite.archives-ouvertes.fr/hal-03596297 doi:10.1016/j.aquatox.2007.04.009 |
op_doi |
https://doi.org/10.1016/j.aquatox.2007.04.009 |
container_title |
Aquatic Toxicology |
container_volume |
83 |
container_issue |
4 |
container_start_page |
254 |
op_container_end_page |
262 |
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1766393674673946624 |