Joint nested frailty models for clustered recurrent and terminal events: An application to colonoscopy screening visits and colorectal cancer risks in Lynch Syndrome families

• Published in: Statistical Methods in Medical Research
• Main Authors: CHOI, Y. H., Jacqmin-Gadda, Helene, Krol, A., PARFREY, P., BRIOLLAIS, L., Rondeau, Virginie
• Other Authors: Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2020
• Subjects: Biostatistics; EPICENE; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; Lynch; Newfoundland
• Online Access: https://hal.archives-ouvertes.fr/hal-03116171; https://doi.org/10.1177/0962280219863076

Joint models for recurrent and terminal events have not been yet developed for clustered data. The goals of our study are to develop a statistical framework for modelling clustered recurrent and terminal events and to perform dynamic predictions of the terminal event in family studies. We propose a...