Joint nested frailty models for clustered recurrent and terminal events: An application to colonoscopy screening visits and colorectal cancer risks in Lynch Syndrome families
Joint models for recurrent and terminal events have not been yet developed for clustered data. The goals of our study are to develop a statistical framework for modelling clustered recurrent and terminal events and to perform dynamic predictions of the terminal event in family studies. We propose a...
Published in: | Statistical Methods in Medical Research |
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Online Access: | https://hal.archives-ouvertes.fr/hal-03116171 https://doi.org/10.1177/0962280219863076 |
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ftccsdartic:oai:HAL:hal-03116171v1 2023-05-15T17:22:32+02:00 Joint nested frailty models for clustered recurrent and terminal events: An application to colonoscopy screening visits and colorectal cancer risks in Lynch Syndrome families CHOI, Y. H. Jacqmin-Gadda, Helene Krol, A. PARFREY, P. BRIOLLAIS, L. Rondeau, Virginie Bordeaux population health (BPH) Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM) 2020 https://hal.archives-ouvertes.fr/hal-03116171 https://doi.org/10.1177/0962280219863076 en eng HAL CCSD SAGE Publications info:eu-repo/semantics/altIdentifier/doi/10.1177/0962280219863076 hal-03116171 https://hal.archives-ouvertes.fr/hal-03116171 doi:10.1177/0962280219863076 ISSN: 0962-2802 Statistical Methods in Medical Research https://hal.archives-ouvertes.fr/hal-03116171 Statistical Methods in Medical Research, SAGE Publications, In press, 5 (29), pp.1466-1479. ⟨10.1177/0962280219863076⟩ Biostatistics EPICENE [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie info:eu-repo/semantics/article Journal articles 2020 ftccsdartic https://doi.org/10.1177/0962280219863076 2021-12-25T23:36:54Z Joint models for recurrent and terminal events have not been yet developed for clustered data. The goals of our study are to develop a statistical framework for modelling clustered recurrent and terminal events and to perform dynamic predictions of the terminal event in family studies. We propose a joint nested frailty model for colonoscopy screening visits and colorectal cancer onset in Lynch Syndrome families. The screening and disease processes could each depend on individuals' screening history and other measured covariates and be correlated within families; our approach allows for familial correlations to affect both the visit process and the terminal event and the dependence between the two processes is specified through frailty distributions. We provide dynamic predictions of colorectal cancer risk for an individual conditional on his/her own screening history, his/her family history of screening and disease and other important clinical covariates. We apply our model to 18 Lynch Syndrome families from Newfoundland for individualized dynamic predictions of colorectal cancer risks. We demonstrate that the screening visits are non-ignorable for estimating the disease risks, and the joint nested frailty model improves dynamic prediction accuracies compared to existing joint frailty models after accounting for familial and individual screening and cancer histories. Article in Journal/Newspaper Newfoundland Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Lynch ENVELOPE(-57.683,-57.683,-63.783,-63.783) Statistical Methods in Medical Research 29 5 1466 1479 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
Biostatistics EPICENE [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
spellingShingle |
Biostatistics EPICENE [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie CHOI, Y. H. Jacqmin-Gadda, Helene Krol, A. PARFREY, P. BRIOLLAIS, L. Rondeau, Virginie Joint nested frailty models for clustered recurrent and terminal events: An application to colonoscopy screening visits and colorectal cancer risks in Lynch Syndrome families |
topic_facet |
Biostatistics EPICENE [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
description |
Joint models for recurrent and terminal events have not been yet developed for clustered data. The goals of our study are to develop a statistical framework for modelling clustered recurrent and terminal events and to perform dynamic predictions of the terminal event in family studies. We propose a joint nested frailty model for colonoscopy screening visits and colorectal cancer onset in Lynch Syndrome families. The screening and disease processes could each depend on individuals' screening history and other measured covariates and be correlated within families; our approach allows for familial correlations to affect both the visit process and the terminal event and the dependence between the two processes is specified through frailty distributions. We provide dynamic predictions of colorectal cancer risk for an individual conditional on his/her own screening history, his/her family history of screening and disease and other important clinical covariates. We apply our model to 18 Lynch Syndrome families from Newfoundland for individualized dynamic predictions of colorectal cancer risks. We demonstrate that the screening visits are non-ignorable for estimating the disease risks, and the joint nested frailty model improves dynamic prediction accuracies compared to existing joint frailty models after accounting for familial and individual screening and cancer histories. |
author2 |
Bordeaux population health (BPH) Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
format |
Article in Journal/Newspaper |
author |
CHOI, Y. H. Jacqmin-Gadda, Helene Krol, A. PARFREY, P. BRIOLLAIS, L. Rondeau, Virginie |
author_facet |
CHOI, Y. H. Jacqmin-Gadda, Helene Krol, A. PARFREY, P. BRIOLLAIS, L. Rondeau, Virginie |
author_sort |
CHOI, Y. H. |
title |
Joint nested frailty models for clustered recurrent and terminal events: An application to colonoscopy screening visits and colorectal cancer risks in Lynch Syndrome families |
title_short |
Joint nested frailty models for clustered recurrent and terminal events: An application to colonoscopy screening visits and colorectal cancer risks in Lynch Syndrome families |
title_full |
Joint nested frailty models for clustered recurrent and terminal events: An application to colonoscopy screening visits and colorectal cancer risks in Lynch Syndrome families |
title_fullStr |
Joint nested frailty models for clustered recurrent and terminal events: An application to colonoscopy screening visits and colorectal cancer risks in Lynch Syndrome families |
title_full_unstemmed |
Joint nested frailty models for clustered recurrent and terminal events: An application to colonoscopy screening visits and colorectal cancer risks in Lynch Syndrome families |
title_sort |
joint nested frailty models for clustered recurrent and terminal events: an application to colonoscopy screening visits and colorectal cancer risks in lynch syndrome families |
publisher |
HAL CCSD |
publishDate |
2020 |
url |
https://hal.archives-ouvertes.fr/hal-03116171 https://doi.org/10.1177/0962280219863076 |
long_lat |
ENVELOPE(-57.683,-57.683,-63.783,-63.783) |
geographic |
Lynch |
geographic_facet |
Lynch |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
ISSN: 0962-2802 Statistical Methods in Medical Research https://hal.archives-ouvertes.fr/hal-03116171 Statistical Methods in Medical Research, SAGE Publications, In press, 5 (29), pp.1466-1479. ⟨10.1177/0962280219863076⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1177/0962280219863076 hal-03116171 https://hal.archives-ouvertes.fr/hal-03116171 doi:10.1177/0962280219863076 |
op_doi |
https://doi.org/10.1177/0962280219863076 |
container_title |
Statistical Methods in Medical Research |
container_volume |
29 |
container_issue |
5 |
container_start_page |
1466 |
op_container_end_page |
1479 |
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1766109247932727296 |