Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar)
International audience AbstractViral diseases are among the main challenges in farming of Atlantic salmon (Salmo salar). The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD...
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ftccsdartic:oai:HAL:hal-02973469v1 2023-05-15T15:30:37+02:00 Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) Lund, Morten Røsæg, Magnus Vikan Krasnov, Aleksei Timmerhaus, Gerrit Nyman, Ingvild Berg Aspehaug, Vidar Rimstad, Espen Dahle, Maria Krudtaa 2016-12 https://hal.archives-ouvertes.fr/hal-02973469 https://hal.archives-ouvertes.fr/hal-02973469/document https://hal.archives-ouvertes.fr/hal-02973469/file/springer.pdf https://doi.org/10.1186/s13567-016-0389-y en eng HAL CCSD BioMed Central info:eu-repo/semantics/altIdentifier/doi/10.1186/s13567-016-0389-y hal-02973469 https://hal.archives-ouvertes.fr/hal-02973469 https://hal.archives-ouvertes.fr/hal-02973469/document https://hal.archives-ouvertes.fr/hal-02973469/file/springer.pdf doi:10.1186/s13567-016-0389-y info:eu-repo/semantics/OpenAccess ISSN: 0928-4249 EISSN: 1297-9716 Veterinary Research https://hal.archives-ouvertes.fr/hal-02973469 Veterinary Research, BioMed Central, 2016, 47 (1), pp.107. ⟨10.1186/s13567-016-0389-y⟩ [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2016 ftccsdartic https://doi.org/10.1186/s13567-016-0389-y 2021-02-20T23:31:10Z International audience AbstractViral diseases are among the main challenges in farming of Atlantic salmon (Salmo salar). The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus (SAV). Both PRV and SAV target heart and skeletal muscles, but SAV additionally targets exocrine pancreas. PRV and SAV are often present in the same locations and co-infections occur, but the effect of this crosstalk on disease development has not been investigated. In the present experiment, the effect of a primary PRV infection on subsequent SAV infection was studied. Atlantic salmon were infected with PRV by cohabitation, followed by addition of SAV shedder fish 4 or 10 weeks after the initial PRV infection. Histopathological evaluation, monitoring of viral RNA levels and host gene expression analysis were used to assess disease development. Significant reduction of SAV RNA levels and of PD specific histopathological changes were observed in the co-infected groups compared to fish infected by SAV only. A strong correlation was found between histopathological development and expression of disease related genes in heart. In conclusion, experimentally PRV infected salmon are less susceptible to secondary SAV infection and development of PD. Article in Journal/Newspaper Atlantic salmon Salmo salar Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Sav’ ENVELOPE(156.400,156.400,68.817,68.817) Veterinary Research 47 1 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
[SDV]Life Sciences [q-bio] |
spellingShingle |
[SDV]Life Sciences [q-bio] Lund, Morten Røsæg, Magnus Vikan Krasnov, Aleksei Timmerhaus, Gerrit Nyman, Ingvild Berg Aspehaug, Vidar Rimstad, Espen Dahle, Maria Krudtaa Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) |
topic_facet |
[SDV]Life Sciences [q-bio] |
description |
International audience AbstractViral diseases are among the main challenges in farming of Atlantic salmon (Salmo salar). The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus (SAV). Both PRV and SAV target heart and skeletal muscles, but SAV additionally targets exocrine pancreas. PRV and SAV are often present in the same locations and co-infections occur, but the effect of this crosstalk on disease development has not been investigated. In the present experiment, the effect of a primary PRV infection on subsequent SAV infection was studied. Atlantic salmon were infected with PRV by cohabitation, followed by addition of SAV shedder fish 4 or 10 weeks after the initial PRV infection. Histopathological evaluation, monitoring of viral RNA levels and host gene expression analysis were used to assess disease development. Significant reduction of SAV RNA levels and of PD specific histopathological changes were observed in the co-infected groups compared to fish infected by SAV only. A strong correlation was found between histopathological development and expression of disease related genes in heart. In conclusion, experimentally PRV infected salmon are less susceptible to secondary SAV infection and development of PD. |
format |
Article in Journal/Newspaper |
author |
Lund, Morten Røsæg, Magnus Vikan Krasnov, Aleksei Timmerhaus, Gerrit Nyman, Ingvild Berg Aspehaug, Vidar Rimstad, Espen Dahle, Maria Krudtaa |
author_facet |
Lund, Morten Røsæg, Magnus Vikan Krasnov, Aleksei Timmerhaus, Gerrit Nyman, Ingvild Berg Aspehaug, Vidar Rimstad, Espen Dahle, Maria Krudtaa |
author_sort |
Lund, Morten |
title |
Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) |
title_short |
Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) |
title_full |
Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) |
title_fullStr |
Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) |
title_full_unstemmed |
Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) |
title_sort |
experimental piscine orthoreovirus infection mediates protection against pancreas disease in atlantic salmon (salmo salar) |
publisher |
HAL CCSD |
publishDate |
2016 |
url |
https://hal.archives-ouvertes.fr/hal-02973469 https://hal.archives-ouvertes.fr/hal-02973469/document https://hal.archives-ouvertes.fr/hal-02973469/file/springer.pdf https://doi.org/10.1186/s13567-016-0389-y |
long_lat |
ENVELOPE(156.400,156.400,68.817,68.817) |
geographic |
Sav’ |
geographic_facet |
Sav’ |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
ISSN: 0928-4249 EISSN: 1297-9716 Veterinary Research https://hal.archives-ouvertes.fr/hal-02973469 Veterinary Research, BioMed Central, 2016, 47 (1), pp.107. ⟨10.1186/s13567-016-0389-y⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13567-016-0389-y hal-02973469 https://hal.archives-ouvertes.fr/hal-02973469 https://hal.archives-ouvertes.fr/hal-02973469/document https://hal.archives-ouvertes.fr/hal-02973469/file/springer.pdf doi:10.1186/s13567-016-0389-y |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1186/s13567-016-0389-y |
container_title |
Veterinary Research |
container_volume |
47 |
container_issue |
1 |
_version_ |
1766361068936888320 |