Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator
International audience Environmental factors that can influence telomeres are diverse, but the association between telomeres and exposure to environmental contaminants is far to be elucidated. To date, prior studies focused on legacy persistent chlorinated pollutants POPs, while the effects of poly-...
Published in: | Environmental Science & Technology |
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Online Access: | https://hal.archives-ouvertes.fr/hal-02910928 https://doi.org/10.1021/acs.est.0c03099 |
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ftccsdartic:oai:HAL:hal-02910928v1 2023-05-15T15:00:26+02:00 Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator Sebastiano, Manrico Angelier, Frédéric BLEVIN, Pierre Ribout, Cecile SAGERUP, Kjetil Descamps, Sebastien Herzke, Dorte, Moe, Borge Barbraud, Christophe Bustnes, Jan Ove Gabrielsen, Geir Wing Chastel, Olivier Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Akvaplan-Niva Tromsø Norwegian Institute for Water Research (NIVA) Norwegian Polar Institute, Fram Centre Norwegian Institute for Air Research (NILU) Division of Arctic Ecology (NINA) Norwegian Institute for Nature Research (NINA) Norvegian Polar Research Institute (NPRI) Norwegian Polar Institute ANR-16-CE34-0005,ILETOP,Impact des polluants historiques et émergents sur les prédateurs supérieurs marins de l'Arctique(2016) 2020 https://hal.archives-ouvertes.fr/hal-02910928 https://doi.org/10.1021/acs.est.0c03099 en eng HAL CCSD American Chemical Society info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.est.0c03099 hal-02910928 https://hal.archives-ouvertes.fr/hal-02910928 doi:10.1021/acs.est.0c03099 ISSN: 0013-936X EISSN: 1520-5851 Environmental Science and Technology https://hal.archives-ouvertes.fr/hal-02910928 Environmental Science and Technology, American Chemical Society, 2020, 54 (16), pp.10217-10226. ⟨10.1021/acs.est.0c03099⟩ [SDE]Environmental Sciences info:eu-repo/semantics/article Journal articles 2020 ftccsdartic https://doi.org/10.1021/acs.est.0c03099 2021-11-07T00:49:25Z International audience Environmental factors that can influence telomeres are diverse, but the association between telomeres and exposure to environmental contaminants is far to be elucidated. To date, prior studies focused on legacy persistent chlorinated pollutants POPs, while the effects of poly- and per-fluoroalkyl substances (PFAS) have poorly been documented. Here, we investigated the associations among PFAS congeners, absolute telomere length (cross-sectional approach), and telomere dynamics (rate of telomere length change over time, longitudinal approach), in one of the most contaminated arctic top predators, the glaucous gull Larus hyperboreus from Svalbard. We further estimated the effect of PFAS on apparent survival rates and re-sighting probabilities using a 10-year capture/recapture dataset (2010-2019). We found that birds exposed to higher concentration of perfluorononadecanoate PFNA (median of 1565 pg/mL of ww in males and 1370 pg/mL of ww in females) and perfluorotetradecanoate PFTeDA (median of 370 pg/mL of ww in males and 210 pg/mL of ww in females) showed the slowest rate of telomere shortening. We also found that high blood concentration of perfluorooctanoate PFOA (median of 120 pg/mL of ww in males and 150 pg/mL of ww in females) and perfluorohexanesulfonate PFHxS (median of 495 pg/mL of ww in males and 395 pg/mL of ww in females) were positively associated with higher re-sighting probabilities and apparent survival in males but not in females. Our work is the first to report an association between single PFAS compounds and telomeres, and the first to link PFAS exposure with survival probabilities, suggesting that the effect of PFAS exposure might be more tied to the type of compound rather than the total concentration of PFAS. Article in Journal/Newspaper Arctic Glaucous Gull Larus hyperboreus Svalbard Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Arctic Svalbard Environmental Science & Technology 54 16 10217 10226 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
[SDE]Environmental Sciences |
spellingShingle |
[SDE]Environmental Sciences Sebastiano, Manrico Angelier, Frédéric BLEVIN, Pierre Ribout, Cecile SAGERUP, Kjetil Descamps, Sebastien Herzke, Dorte, Moe, Borge Barbraud, Christophe Bustnes, Jan Ove Gabrielsen, Geir Wing Chastel, Olivier Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
topic_facet |
[SDE]Environmental Sciences |
description |
International audience Environmental factors that can influence telomeres are diverse, but the association between telomeres and exposure to environmental contaminants is far to be elucidated. To date, prior studies focused on legacy persistent chlorinated pollutants POPs, while the effects of poly- and per-fluoroalkyl substances (PFAS) have poorly been documented. Here, we investigated the associations among PFAS congeners, absolute telomere length (cross-sectional approach), and telomere dynamics (rate of telomere length change over time, longitudinal approach), in one of the most contaminated arctic top predators, the glaucous gull Larus hyperboreus from Svalbard. We further estimated the effect of PFAS on apparent survival rates and re-sighting probabilities using a 10-year capture/recapture dataset (2010-2019). We found that birds exposed to higher concentration of perfluorononadecanoate PFNA (median of 1565 pg/mL of ww in males and 1370 pg/mL of ww in females) and perfluorotetradecanoate PFTeDA (median of 370 pg/mL of ww in males and 210 pg/mL of ww in females) showed the slowest rate of telomere shortening. We also found that high blood concentration of perfluorooctanoate PFOA (median of 120 pg/mL of ww in males and 150 pg/mL of ww in females) and perfluorohexanesulfonate PFHxS (median of 495 pg/mL of ww in males and 395 pg/mL of ww in females) were positively associated with higher re-sighting probabilities and apparent survival in males but not in females. Our work is the first to report an association between single PFAS compounds and telomeres, and the first to link PFAS exposure with survival probabilities, suggesting that the effect of PFAS exposure might be more tied to the type of compound rather than the total concentration of PFAS. |
author2 |
Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Akvaplan-Niva Tromsø Norwegian Institute for Water Research (NIVA) Norwegian Polar Institute, Fram Centre Norwegian Institute for Air Research (NILU) Division of Arctic Ecology (NINA) Norwegian Institute for Nature Research (NINA) Norvegian Polar Research Institute (NPRI) Norwegian Polar Institute ANR-16-CE34-0005,ILETOP,Impact des polluants historiques et émergents sur les prédateurs supérieurs marins de l'Arctique(2016) |
format |
Article in Journal/Newspaper |
author |
Sebastiano, Manrico Angelier, Frédéric BLEVIN, Pierre Ribout, Cecile SAGERUP, Kjetil Descamps, Sebastien Herzke, Dorte, Moe, Borge Barbraud, Christophe Bustnes, Jan Ove Gabrielsen, Geir Wing Chastel, Olivier |
author_facet |
Sebastiano, Manrico Angelier, Frédéric BLEVIN, Pierre Ribout, Cecile SAGERUP, Kjetil Descamps, Sebastien Herzke, Dorte, Moe, Borge Barbraud, Christophe Bustnes, Jan Ove Gabrielsen, Geir Wing Chastel, Olivier |
author_sort |
Sebastiano, Manrico |
title |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_short |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_full |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_fullStr |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_full_unstemmed |
Exposure to PFAS is associated with telomere length dynamics and demographic responses of an arctic top predator |
title_sort |
exposure to pfas is associated with telomere length dynamics and demographic responses of an arctic top predator |
publisher |
HAL CCSD |
publishDate |
2020 |
url |
https://hal.archives-ouvertes.fr/hal-02910928 https://doi.org/10.1021/acs.est.0c03099 |
geographic |
Arctic Svalbard |
geographic_facet |
Arctic Svalbard |
genre |
Arctic Glaucous Gull Larus hyperboreus Svalbard |
genre_facet |
Arctic Glaucous Gull Larus hyperboreus Svalbard |
op_source |
ISSN: 0013-936X EISSN: 1520-5851 Environmental Science and Technology https://hal.archives-ouvertes.fr/hal-02910928 Environmental Science and Technology, American Chemical Society, 2020, 54 (16), pp.10217-10226. ⟨10.1021/acs.est.0c03099⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.est.0c03099 hal-02910928 https://hal.archives-ouvertes.fr/hal-02910928 doi:10.1021/acs.est.0c03099 |
op_doi |
https://doi.org/10.1021/acs.est.0c03099 |
container_title |
Environmental Science & Technology |
container_volume |
54 |
container_issue |
16 |
container_start_page |
10217 |
op_container_end_page |
10226 |
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1766332539094433792 |