Reasons for the Failure of Platelet Function Testing to Adjust Antiplatelet Therapy

• Published in: Circulation: Cardiovascular Interventions
• Main Authors: Lattuca, Benoit, Silvain, Johanne, Yan, Yan, Pouillot, Christophe, Cuisset, Thomas, Cayla, Guillaume, Henry, Patrick, Diallo, Abdourahmane, Elhadad, Simon, Range, Grégoire, Lhermusier, Thibault, Boueri, Ziad, Motreff, Pascal, Carrie, Didier, Vicaut, Eric, Montalescot, Gilles, Collet, Jean-Philippe
• Other Authors: Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut de cardiologie CHU Pitié-Salpêtrière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière AP-HP, University of Science and Technology Beijing Beijing (USTB), Clinique Sainte Clotilde, Hôpital de la Timone CHU - APHM (TIMONE), Hôpital Lariboisière-Fernand-Widal APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal, Service de Cardiologie, Centre Hospitalier Lagny-Marne la Vallée, Hôpital Louis Pasteur Chartres, Service de cardiologie Toulouse, Hôpital de Rangueil, CHU Toulouse Toulouse -CHU Toulouse Toulouse, Hôpital de Bastia, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne 2017-2020 (UCA 2017-2020 )-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie Thoracique et Cardiovasculaire CHU Pitié-Salpêtrière, CHU Pitié-Salpêtrière AP-HP, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2019
• Subjects: clopidogrel; myocardial infarction; percutaneous coronary intervention; platelet function test; platelet reactivity; thrombosis; [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system; Arctic; Stent; Human health
• Online Access: https://hal.archives-ouvertes.fr/hal-02869075; https://doi.org/10.1161/CIRCINTERVENTIONS.118.007749

International audience In the ARCTIC trial (Assessment by a Double Randomization of a Conventional Antiplatelet Strategy Versus a Monitoring-Guided Strategy for Drug-Eluting Stent Implantation and of Treatment Interruption Versus Continuation One Year After Stenting), treatment adjustment following platelet function testing failed to improve clinical outcomes. However, high-on-treatment platelet reactivity (HPR) is considered as a predictor of poor ischemic outcome. This prespecified substudy evaluated clinical outcomes according to the residual platelet reactivity status after antiplatelet therapy adjustment. URL: https://www.clinicaltrials.gov. Unique identifier: NCT00827411.