Molecular characterization of a new leucine-rich repeat-containing G protein-coupled receptor from a bivalve mollusc: evolutionary implications.

International audience The family of leucine-rich repeat-containing G protein-coupled receptors (LGRs) shows members in both vertebrates and invertebrates including the most ancestral ones. Although this suggests an early evolutionary origin of this family of receptors, little is known about their d...

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Bibliographic Details
Published in:Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
Main Authors: Herpin, Amaury, Badariotti, Fabien, Rodet, Frank, Favrel, Pascal
Other Authors: Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Conseil Regional de Basse-Normandie & Agence de l’Eau "Seine- Normandie" (France)
Format: Article in Journal/Newspaper
Language:English
Published: HAL CCSD 2004
Subjects:
G protein-coupled receptor
Phylogeny
glycoprotein hormone receptor
leucine-rich repeat
lophotrochozoa
mollusc
[SDV.BA]Life Sciences [q-bio]/Animal biology
[SDV.BDD]Life Sciences [q-bio]/Development Biology
[SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology
Crassostrea gigas
Online Access:https://hal.inrae.fr/hal-02682204
https://doi.org/10.1016/j.bbaexp.2004.09.003
Description
Summary:International audience The family of leucine-rich repeat-containing G protein-coupled receptors (LGRs) shows members in both vertebrates and invertebrates including the most ancestral ones. Although this suggests an early evolutionary origin of this family of receptors, little is known about their diversity in molluscs, a major phylum of bilaterian invertebrates. Based on sequences of mammalian and insect LGRs, we have cloned and characterized a new typical LGR in the bivalve mollusc Crassostrea gigas. This receptor named Cg-LGRB exhibits high degree of amino acid sequence identity with both mammalian and Drosophila LGRs. Phylogenetic analysis indicates that Cg-LGRB belongs to the cluster of type B orphan LGRs and suggests that molluscs likely express the three LGR subgroups identified previously in other animals. Quantitative RT-PCR shows that Cg-LGRB is expressed mainly in the digestive gland and only at moderate levels in other organs and developmental stages. A possible involvement in the control of cytological changes occurring in bivalve mollusc digestive gland is discussed.

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