Spread of antibiotic resistance in water: a public health and environmental issue
(IF N/A; Q4) International audience Genes encoding antibiotic resistance have been found in DNA present in 30,000-year-old permafrost sediment and in areas without human activity. Antibiotics belong to a class of small bioactive molecules secreted by environmental microorganisms. Since 1950, intensi...
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ftccsdartic:oai:HAL:hal-02438961v1 2023-05-15T17:58:08+02:00 Spread of antibiotic resistance in water: a public health and environmental issue Petit, Fabienne Morphodynamique Continentale et Côtière (M2C) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rouen Normandie (UNIROUEN) Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS) 2018-04 https://hal-normandie-univ.archives-ouvertes.fr/hal-02438961 https://doi.org/10.1684/ers.2017.1098 en eng HAL CCSD John Libbey Eurotext info:eu-repo/semantics/altIdentifier/doi/10.1684/ers.2017.1098 hal-02438961 https://hal-normandie-univ.archives-ouvertes.fr/hal-02438961 doi:10.1684/ers.2017.1098 ISSN: 1635-0421 Environnement, Risques and Santé https://hal-normandie-univ.archives-ouvertes.fr/hal-02438961 Environnement, Risques and Santé, John Libbey Eurotext, 2018, 17, pp.40-46. ⟨10.1684/ers.2017.1098⟩ résistance aux antibiotiques agents antibactérien eau estuaire [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology [SDV.EE]Life Sciences [q-bio]/Ecology environment info:eu-repo/semantics/article Journal articles 2018 ftccsdartic https://doi.org/10.1684/ers.2017.1098 2021-11-07T01:24:33Z (IF N/A; Q4) International audience Genes encoding antibiotic resistance have been found in DNA present in 30,000-year-old permafrost sediment and in areas without human activity. Antibiotics belong to a class of small bioactive molecules secreted by environmental microorganisms. Since 1950, intensive use of antibiotics in human and veterinary medicine has been accompanied by an unprecedented increase in bacterial resistance in clinical settings, and a contamination of the environment, mainly surface water, by antibiotics and by antibiotic-resistant (ATBr) bacteria. To further illustrate this problem, we study here the fate of both antibiotic and antibiotic-resistant fecal bacteria in the Seine estuary in France, highly impacted by humans. Thus, ATBr Escherichia coli and ATBr Enterococcus spp. were investigated along a medical center-wastewater treatment plant-river continuum and along a rural hydrological continuum, in relation to antibiotic prescription and contamination of surface water. To date, notwithstanding the spread of ATBr bacteria in aquatic environments, it remains difficult to estimate their risk to human health. Environmental contamination by ATBr bacteria could be linked to the transfer of clinical integrons and antibiotic resistance genes to (i) environmental strains that are opportunistic pathogens in humans, or (ii) environmental organisms that may secondarily transfer such genes to strains that are pathogenic in humans. One of the major scientific challenges of the decades to come will be the evaluation of the vulnerability and resilience of the aquatic environment to contamination by ATBr bacteria and their genes. For this purpose, collaborative research should be conducted, supported by environmental observatories and in accordance with the DPSIR (Driving forces-Pressure-State-Impact-Response) concept. Article in Journal/Newspaper permafrost Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
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collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
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ftccsdartic |
language |
English |
topic |
résistance aux antibiotiques agents antibactérien eau estuaire [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology [SDV.EE]Life Sciences [q-bio]/Ecology environment |
spellingShingle |
résistance aux antibiotiques agents antibactérien eau estuaire [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology [SDV.EE]Life Sciences [q-bio]/Ecology environment Petit, Fabienne Spread of antibiotic resistance in water: a public health and environmental issue |
topic_facet |
résistance aux antibiotiques agents antibactérien eau estuaire [SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology [SDV.EE]Life Sciences [q-bio]/Ecology environment |
description |
(IF N/A; Q4) International audience Genes encoding antibiotic resistance have been found in DNA present in 30,000-year-old permafrost sediment and in areas without human activity. Antibiotics belong to a class of small bioactive molecules secreted by environmental microorganisms. Since 1950, intensive use of antibiotics in human and veterinary medicine has been accompanied by an unprecedented increase in bacterial resistance in clinical settings, and a contamination of the environment, mainly surface water, by antibiotics and by antibiotic-resistant (ATBr) bacteria. To further illustrate this problem, we study here the fate of both antibiotic and antibiotic-resistant fecal bacteria in the Seine estuary in France, highly impacted by humans. Thus, ATBr Escherichia coli and ATBr Enterococcus spp. were investigated along a medical center-wastewater treatment plant-river continuum and along a rural hydrological continuum, in relation to antibiotic prescription and contamination of surface water. To date, notwithstanding the spread of ATBr bacteria in aquatic environments, it remains difficult to estimate their risk to human health. Environmental contamination by ATBr bacteria could be linked to the transfer of clinical integrons and antibiotic resistance genes to (i) environmental strains that are opportunistic pathogens in humans, or (ii) environmental organisms that may secondarily transfer such genes to strains that are pathogenic in humans. One of the major scientific challenges of the decades to come will be the evaluation of the vulnerability and resilience of the aquatic environment to contamination by ATBr bacteria and their genes. For this purpose, collaborative research should be conducted, supported by environmental observatories and in accordance with the DPSIR (Driving forces-Pressure-State-Impact-Response) concept. |
author2 |
Morphodynamique Continentale et Côtière (M2C) Université de Caen Normandie (UNICAEN) Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rouen Normandie (UNIROUEN) Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS) |
format |
Article in Journal/Newspaper |
author |
Petit, Fabienne |
author_facet |
Petit, Fabienne |
author_sort |
Petit, Fabienne |
title |
Spread of antibiotic resistance in water: a public health and environmental issue |
title_short |
Spread of antibiotic resistance in water: a public health and environmental issue |
title_full |
Spread of antibiotic resistance in water: a public health and environmental issue |
title_fullStr |
Spread of antibiotic resistance in water: a public health and environmental issue |
title_full_unstemmed |
Spread of antibiotic resistance in water: a public health and environmental issue |
title_sort |
spread of antibiotic resistance in water: a public health and environmental issue |
publisher |
HAL CCSD |
publishDate |
2018 |
url |
https://hal-normandie-univ.archives-ouvertes.fr/hal-02438961 https://doi.org/10.1684/ers.2017.1098 |
genre |
permafrost |
genre_facet |
permafrost |
op_source |
ISSN: 1635-0421 Environnement, Risques and Santé https://hal-normandie-univ.archives-ouvertes.fr/hal-02438961 Environnement, Risques and Santé, John Libbey Eurotext, 2018, 17, pp.40-46. ⟨10.1684/ers.2017.1098⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1684/ers.2017.1098 hal-02438961 https://hal-normandie-univ.archives-ouvertes.fr/hal-02438961 doi:10.1684/ers.2017.1098 |
op_doi |
https://doi.org/10.1684/ers.2017.1098 |
_version_ |
1766166679407034368 |