Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos)

International audience Oxidative stress, which is believed to promote muscle atrophy, has been reported to occurin a few hibernators. However, hibernating bears exhibit ecient energy savings and muscle proteinsparing, despite long-term physical inactivity and fasting. We hypothesized that the regula...

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Bibliographic Details
Published in:Antioxidants
Main Authors: Chazarin, Blandine, Ziemianin, Anna, Evans, Alina L., Meugnier, Emmanuelle, Loizon, Emmanuelle, Chery, Isabelle, Arnemo, Jon M., Swenson, Jon E., Gauquelin-Koch, Guillemette, Simon, Chantal, Blanc, Stéphane, Lefai, Etienne, Bertile, Fabrice
Other Authors: Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Etudes Spatiales, Department of Forestry and Wildlife Management Inland Norway University of Applied Sciences, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences (SLU), Faculty of Environmental Sciences and Natural Resource Management, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne 2017-2020 (UCA 2017-2020 )
Format: Article in Journal/Newspaper
Language:English
Published: HAL CCSD 2019
Subjects:
hibernation
brown bears
skeletal muscle
cold response
NRF2
oxidative stress
[SDE]Environmental Sciences
Ursus arctos
Online Access:https://hal.archives-ouvertes.fr/hal-02274540
https://hal.archives-ouvertes.fr/hal-02274540/document
https://hal.archives-ouvertes.fr/hal-02274540/file/antioxidants-08-00334-v2.pdf
https://doi.org/10.3390/antiox8090334
Description
Summary:International audience Oxidative stress, which is believed to promote muscle atrophy, has been reported to occurin a few hibernators. However, hibernating bears exhibit ecient energy savings and muscle proteinsparing, despite long-term physical inactivity and fasting. We hypothesized that the regulation ofthe oxidant/antioxidant balance and oxidative stress could favor skeletal muscle maintenance inhibernating brown bears. We showed that increased expressions of cold-inducible proteins CIRBPand RBM3 could favor muscle mass maintenance and alleviate oxidative stress during hibernation.Downregulation of the subunits of the mitochondrial electron transfer chain complexes I, II, and III,and antioxidant enzymes, possibly due to the reduced mitochondrial content, indicated a possiblereduction of the production of reactive oxygen species in the hibernating muscle. Concomitantly, theupregulation of cytosolic antioxidant systems, under the control of the transcription factor NRF2, andthe maintenance of the GSH/GSSG ratio suggested that bear skeletal muscle is not under a significantoxidative insult during hibernation. Accordingly, lower levels of oxidative damage were recorded inhibernating bear skeletal muscles. These results identify mechanisms by which limited oxidativestress may underlie the resistance to skeletal muscle atrophy in hibernatin

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