Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to perfluoroalkyl carboxylic acids
International audience Perfluoroalkyl and polyfluoroalkyl substances (PFASs) may cause detrimental effects on physiological function and reproduction of Arctic animals. However, there is a paucity of information on the link between PFASs and oxidative stress, which can have potential detrimental eff...
Published in: | Environmental Research |
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Online Access: | https://hal.archives-ouvertes.fr/hal-02238536 https://hal.archives-ouvertes.fr/hal-02238536/document https://hal.archives-ouvertes.fr/hal-02238536/file/Costantini%20et%20al.%20-%202019%20-%20Higher%20plasma%20oxidative%20damage%20and%20lower%20plasma%20an.pdf https://doi.org/10.1016/j.envres.2018.10.003 |
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ftccsdartic:oai:HAL:hal-02238536v1 2023-05-15T14:54:14+02:00 Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to perfluoroalkyl carboxylic acids Costantini, David Blévin, Pierre Herzke, Dorte Moe, Borge Gabrielsen, Geir Wing Bustnes, Jan Ove Chastel, Olivier Physiologie moléculaire et adaptation (PhyMA) Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS) Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Norwegian Institute for Air Research (FRAM) High North Research Centre on Climate and the Environment Norwegian Institute for Nature Research (NINA) Fram Centre Norwegian Polar Institute ANR-16-CE34-0005,ILETOP,Impact des polluants historiques et émergents sur les prédateurs supérieurs marins de l'Arctique(2016) 2019-01 https://hal.archives-ouvertes.fr/hal-02238536 https://hal.archives-ouvertes.fr/hal-02238536/document https://hal.archives-ouvertes.fr/hal-02238536/file/Costantini%20et%20al.%20-%202019%20-%20Higher%20plasma%20oxidative%20damage%20and%20lower%20plasma%20an.pdf https://doi.org/10.1016/j.envres.2018.10.003 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envres.2018.10.003 hal-02238536 https://hal.archives-ouvertes.fr/hal-02238536 https://hal.archives-ouvertes.fr/hal-02238536/document https://hal.archives-ouvertes.fr/hal-02238536/file/Costantini%20et%20al.%20-%202019%20-%20Higher%20plasma%20oxidative%20damage%20and%20lower%20plasma%20an.pdf doi:10.1016/j.envres.2018.10.003 info:eu-repo/semantics/OpenAccess ISSN: 0013-9351 EISSN: 1096-0953 Environmental Research https://hal.archives-ouvertes.fr/hal-02238536 Environmental Research, Elsevier, 2019, 168, pp.278-285. ⟨10.1016/j.envres.2018.10.003⟩ Svalbard PFASs Antioxidants Birds Kittiwake [SDE]Environmental Sciences info:eu-repo/semantics/article Journal articles 2019 ftccsdartic https://doi.org/10.1016/j.envres.2018.10.003 2021-11-21T01:16:13Z International audience Perfluoroalkyl and polyfluoroalkyl substances (PFASs) may cause detrimental effects on physiological function and reproduction of Arctic animals. However, there is a paucity of information on the link between PFASs and oxidative stress, which can have potential detrimental effects on key fitness traits, such as cellular homeostasis or reproduction. We have examined the correlations between multiple blood-based markers of oxidative status and several perfluoroalkyl acids (i.e., with 8 or more carbons) in male Arctic black-legged kittiwakes (Rissa tridactyla) during the pre-laying period. Higher protein oxidative damage was found in those birds having higher concentrations of perfluorododecanoic acid (PFDoA), perfluorotridecanoic acid (PFTriA) and perfluorotetradecanoic acid (PFTeA). Lower plasmatic non-enzymatic micro-molecular antioxidants were found in those birds having higher concentrations of perfluoroundecanoic acid (PFUnA), PFDoA and PFTeA. Effect size estimates showed that the significant correlations between PFASs and oxidative status markers were intermediate to strong. The non-enzymatic antioxidant capacity (including antioxidants of protein origin) was significantly lower in those birds having higher plasma concentration of linear perfluorooctanesulfonic acid (PFOSlin). In contrast, the activity of the antioxidant enzyme glutathione peroxidase in erythrocytes was not associated with any PFAS compounds. Our results suggest that increased oxidative stress might be one consequence of long-chain PFASexposure. Experimental work will be needed to demonstrate whether PFASs cause toxic effects on free-living vertebrates through increased oxidative stress. Article in Journal/Newspaper Arctic rissa tridactyla Svalbard Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Arctic Svalbard Environmental Research 168 278 285 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
Svalbard PFASs Antioxidants Birds Kittiwake [SDE]Environmental Sciences |
spellingShingle |
Svalbard PFASs Antioxidants Birds Kittiwake [SDE]Environmental Sciences Costantini, David Blévin, Pierre Herzke, Dorte Moe, Borge Gabrielsen, Geir Wing Bustnes, Jan Ove Chastel, Olivier Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to perfluoroalkyl carboxylic acids |
topic_facet |
Svalbard PFASs Antioxidants Birds Kittiwake [SDE]Environmental Sciences |
description |
International audience Perfluoroalkyl and polyfluoroalkyl substances (PFASs) may cause detrimental effects on physiological function and reproduction of Arctic animals. However, there is a paucity of information on the link between PFASs and oxidative stress, which can have potential detrimental effects on key fitness traits, such as cellular homeostasis or reproduction. We have examined the correlations between multiple blood-based markers of oxidative status and several perfluoroalkyl acids (i.e., with 8 or more carbons) in male Arctic black-legged kittiwakes (Rissa tridactyla) during the pre-laying period. Higher protein oxidative damage was found in those birds having higher concentrations of perfluorododecanoic acid (PFDoA), perfluorotridecanoic acid (PFTriA) and perfluorotetradecanoic acid (PFTeA). Lower plasmatic non-enzymatic micro-molecular antioxidants were found in those birds having higher concentrations of perfluoroundecanoic acid (PFUnA), PFDoA and PFTeA. Effect size estimates showed that the significant correlations between PFASs and oxidative status markers were intermediate to strong. The non-enzymatic antioxidant capacity (including antioxidants of protein origin) was significantly lower in those birds having higher plasma concentration of linear perfluorooctanesulfonic acid (PFOSlin). In contrast, the activity of the antioxidant enzyme glutathione peroxidase in erythrocytes was not associated with any PFAS compounds. Our results suggest that increased oxidative stress might be one consequence of long-chain PFASexposure. Experimental work will be needed to demonstrate whether PFASs cause toxic effects on free-living vertebrates through increased oxidative stress. |
author2 |
Physiologie moléculaire et adaptation (PhyMA) Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS) Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) Norwegian Institute for Air Research (FRAM) High North Research Centre on Climate and the Environment Norwegian Institute for Nature Research (NINA) Fram Centre Norwegian Polar Institute ANR-16-CE34-0005,ILETOP,Impact des polluants historiques et émergents sur les prédateurs supérieurs marins de l'Arctique(2016) |
format |
Article in Journal/Newspaper |
author |
Costantini, David Blévin, Pierre Herzke, Dorte Moe, Borge Gabrielsen, Geir Wing Bustnes, Jan Ove Chastel, Olivier |
author_facet |
Costantini, David Blévin, Pierre Herzke, Dorte Moe, Borge Gabrielsen, Geir Wing Bustnes, Jan Ove Chastel, Olivier |
author_sort |
Costantini, David |
title |
Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to perfluoroalkyl carboxylic acids |
title_short |
Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to perfluoroalkyl carboxylic acids |
title_full |
Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to perfluoroalkyl carboxylic acids |
title_fullStr |
Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to perfluoroalkyl carboxylic acids |
title_full_unstemmed |
Higher plasma oxidative damage and lower plasma antioxidant defences in an Arctic seabird exposed to perfluoroalkyl carboxylic acids |
title_sort |
higher plasma oxidative damage and lower plasma antioxidant defences in an arctic seabird exposed to perfluoroalkyl carboxylic acids |
publisher |
HAL CCSD |
publishDate |
2019 |
url |
https://hal.archives-ouvertes.fr/hal-02238536 https://hal.archives-ouvertes.fr/hal-02238536/document https://hal.archives-ouvertes.fr/hal-02238536/file/Costantini%20et%20al.%20-%202019%20-%20Higher%20plasma%20oxidative%20damage%20and%20lower%20plasma%20an.pdf https://doi.org/10.1016/j.envres.2018.10.003 |
geographic |
Arctic Svalbard |
geographic_facet |
Arctic Svalbard |
genre |
Arctic rissa tridactyla Svalbard |
genre_facet |
Arctic rissa tridactyla Svalbard |
op_source |
ISSN: 0013-9351 EISSN: 1096-0953 Environmental Research https://hal.archives-ouvertes.fr/hal-02238536 Environmental Research, Elsevier, 2019, 168, pp.278-285. ⟨10.1016/j.envres.2018.10.003⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.envres.2018.10.003 hal-02238536 https://hal.archives-ouvertes.fr/hal-02238536 https://hal.archives-ouvertes.fr/hal-02238536/document https://hal.archives-ouvertes.fr/hal-02238536/file/Costantini%20et%20al.%20-%202019%20-%20Higher%20plasma%20oxidative%20damage%20and%20lower%20plasma%20an.pdf doi:10.1016/j.envres.2018.10.003 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1016/j.envres.2018.10.003 |
container_title |
Environmental Research |
container_volume |
168 |
container_start_page |
278 |
op_container_end_page |
285 |
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1766325954346483712 |