Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV)
International audience AbstractInfectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in European Atlantic salmon (Salmo salar) farms, but is considered...
Published in: | Veterinary Research |
---|---|
Main Authors: | , , , , , , , |
Other Authors: | , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2018
|
Subjects: | |
Online Access: | https://hal.archives-ouvertes.fr/hal-01731164 https://hal.archives-ouvertes.fr/hal-01731164/document https://hal.archives-ouvertes.fr/hal-01731164/file/13567_2018_Article_524.pdf https://doi.org/10.1186/s13567-018-0524-z |
id |
ftccsdartic:oai:HAL:hal-01731164v1 |
---|---|
record_format |
openpolar |
spelling |
ftccsdartic:oai:HAL:hal-01731164v1 2023-05-15T15:29:29+02:00 Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) Vendramin, Niccoló Alencar, Anna Luiza Farias Iburg, Tine Moesgaard Dahle, Maria Krudtaa Wessel, Øystein Olsen, Anne Berit Rimstad, Espen Olesen, Niels Jørgen National Veterinary Institute Technical University of Denmark Lyngby (DTU) 2018-12 https://hal.archives-ouvertes.fr/hal-01731164 https://hal.archives-ouvertes.fr/hal-01731164/document https://hal.archives-ouvertes.fr/hal-01731164/file/13567_2018_Article_524.pdf https://doi.org/10.1186/s13567-018-0524-z en eng HAL CCSD BioMed Central info:eu-repo/semantics/altIdentifier/doi/10.1186/s13567-018-0524-z hal-01731164 https://hal.archives-ouvertes.fr/hal-01731164 https://hal.archives-ouvertes.fr/hal-01731164/document https://hal.archives-ouvertes.fr/hal-01731164/file/13567_2018_Article_524.pdf doi:10.1186/s13567-018-0524-z info:eu-repo/semantics/OpenAccess ISSN: 0928-4249 EISSN: 1297-9716 Veterinary Research https://hal.archives-ouvertes.fr/hal-01731164 Veterinary Research, BioMed Central, 2018, 49 (1), pp.30. ⟨10.1186/s13567-018-0524-z⟩ [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2018 ftccsdartic https://doi.org/10.1186/s13567-018-0524-z 2021-02-21T01:04:21Z International audience AbstractInfectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in European Atlantic salmon (Salmo salar) farms, but is considered as a major threat for the European salmon industry. Another virus, Piscine orthoreovirus (PRV), is widespread in the sea phase of Atlantic salmon, and is identified as the causative agent of heart and skeletal muscle inflammation. The aim of this study was to investigate the interactions between a primary PRV infection and a secondary IHNV infection under experimental conditions. A PRV cohabitation challenge was performed with Atlantic salmon. At peak of PRV viremia the fish were challenged by immersion with an IHNV genogroup E isolate. Clinical signs and morbidity were monitored. Target organs were sampled at selected time points to assess viral loads of both pathogens. Antiviral immune response and presence of histopathological findings were also investigated. Whereas the PRV-negative/IHNV positive group suffered significant decrease in survival caused by IHNV, the PRV infected groups did not suffer any morbidity and showed negligible levels of IHNV infection. Antiviral response genes were induced, as measured in spleen samples, from PRV infected fish prior to IHNV challenge. In conclusion, PRV-infection protects Atlantic salmon against IHNV infection and morbidity, most likely by inducing a protective innate antiviral response. Article in Journal/Newspaper Atlantic salmon Salmo salar Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Pacific Veterinary Research 49 1 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
[SDV]Life Sciences [q-bio] |
spellingShingle |
[SDV]Life Sciences [q-bio] Vendramin, Niccoló Alencar, Anna Luiza Farias Iburg, Tine Moesgaard Dahle, Maria Krudtaa Wessel, Øystein Olsen, Anne Berit Rimstad, Espen Olesen, Niels Jørgen Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
topic_facet |
[SDV]Life Sciences [q-bio] |
description |
International audience AbstractInfectious hematopoietic necrosis virus (IHNV) is endemic in farmed rainbow trout in continental Europe and in various salmonid fish species at the Pacific coast of North America. IHN has never occurred in European Atlantic salmon (Salmo salar) farms, but is considered as a major threat for the European salmon industry. Another virus, Piscine orthoreovirus (PRV), is widespread in the sea phase of Atlantic salmon, and is identified as the causative agent of heart and skeletal muscle inflammation. The aim of this study was to investigate the interactions between a primary PRV infection and a secondary IHNV infection under experimental conditions. A PRV cohabitation challenge was performed with Atlantic salmon. At peak of PRV viremia the fish were challenged by immersion with an IHNV genogroup E isolate. Clinical signs and morbidity were monitored. Target organs were sampled at selected time points to assess viral loads of both pathogens. Antiviral immune response and presence of histopathological findings were also investigated. Whereas the PRV-negative/IHNV positive group suffered significant decrease in survival caused by IHNV, the PRV infected groups did not suffer any morbidity and showed negligible levels of IHNV infection. Antiviral response genes were induced, as measured in spleen samples, from PRV infected fish prior to IHNV challenge. In conclusion, PRV-infection protects Atlantic salmon against IHNV infection and morbidity, most likely by inducing a protective innate antiviral response. |
author2 |
National Veterinary Institute Technical University of Denmark Lyngby (DTU) |
format |
Article in Journal/Newspaper |
author |
Vendramin, Niccoló Alencar, Anna Luiza Farias Iburg, Tine Moesgaard Dahle, Maria Krudtaa Wessel, Øystein Olsen, Anne Berit Rimstad, Espen Olesen, Niels Jørgen |
author_facet |
Vendramin, Niccoló Alencar, Anna Luiza Farias Iburg, Tine Moesgaard Dahle, Maria Krudtaa Wessel, Øystein Olsen, Anne Berit Rimstad, Espen Olesen, Niels Jørgen |
author_sort |
Vendramin, Niccoló |
title |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_short |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_full |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_fullStr |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_full_unstemmed |
Piscine orthoreovirus infection in Atlantic salmon (Salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (IHNV) |
title_sort |
piscine orthoreovirus infection in atlantic salmon (salmo salar) protects against subsequent challenge with infectious hematopoietic necrosis virus (ihnv) |
publisher |
HAL CCSD |
publishDate |
2018 |
url |
https://hal.archives-ouvertes.fr/hal-01731164 https://hal.archives-ouvertes.fr/hal-01731164/document https://hal.archives-ouvertes.fr/hal-01731164/file/13567_2018_Article_524.pdf https://doi.org/10.1186/s13567-018-0524-z |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
ISSN: 0928-4249 EISSN: 1297-9716 Veterinary Research https://hal.archives-ouvertes.fr/hal-01731164 Veterinary Research, BioMed Central, 2018, 49 (1), pp.30. ⟨10.1186/s13567-018-0524-z⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13567-018-0524-z hal-01731164 https://hal.archives-ouvertes.fr/hal-01731164 https://hal.archives-ouvertes.fr/hal-01731164/document https://hal.archives-ouvertes.fr/hal-01731164/file/13567_2018_Article_524.pdf doi:10.1186/s13567-018-0524-z |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1186/s13567-018-0524-z |
container_title |
Veterinary Research |
container_volume |
49 |
container_issue |
1 |
_version_ |
1766359905167474688 |