Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B
International audience The study provides detailed information on the differences in the structural, thermal and degradation properties of poly(ε-caprolactone) synthesized in two different ionic liquids, 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] and 1-butyl-3-methylimidazolium bis(...
Published in: | Journal of Applied Polymer Science |
---|---|
Main Authors: | , , , |
Other Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2016
|
Subjects: | |
Online Access: | https://hal.archives-ouvertes.fr/hal-01644363 https://hal.archives-ouvertes.fr/hal-01644363/document https://hal.archives-ouvertes.fr/hal-01644363/file/Piotrowska_18209.pdf https://doi.org/10.1002/app.43728 |
id |
ftccsdartic:oai:HAL:hal-01644363v1 |
---|---|
record_format |
openpolar |
spelling |
ftccsdartic:oai:HAL:hal-01644363v1 2023-05-15T13:31:49+02:00 Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B Piotrowska, Urszula Sobczak, Marcin Oledzka, Ewa Combes, Christèle Medical University of Warsaw - Poland Kazimierz Pulaski University of Technology and Humanities in Radom Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT) Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3) Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP) Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC) 2016 https://hal.archives-ouvertes.fr/hal-01644363 https://hal.archives-ouvertes.fr/hal-01644363/document https://hal.archives-ouvertes.fr/hal-01644363/file/Piotrowska_18209.pdf https://doi.org/10.1002/app.43728 en eng HAL CCSD Wiley info:eu-repo/semantics/altIdentifier/doi/10.1002/app.43728 hal-01644363 https://hal.archives-ouvertes.fr/hal-01644363 https://hal.archives-ouvertes.fr/hal-01644363/document https://hal.archives-ouvertes.fr/hal-01644363/file/Piotrowska_18209.pdf doi:10.1002/app.43728 OATAO: 18209 info:eu-repo/semantics/OpenAccess ISSN: 0021-8995 EISSN: 1097-4628 Journal of Applied Polymer Science https://hal.archives-ouvertes.fr/hal-01644363 Journal of Applied Polymer Science, Wiley, 2016, 133 (31), ⟨10.1002/app.43728⟩ Properties and characterization Polyesters Ionic liquids Degradation Drug delivery systems [CHIM.POLY]Chemical Sciences/Polymers info:eu-repo/semantics/article Journal articles 2016 ftccsdartic https://doi.org/10.1002/app.43728 2021-12-12T03:44:55Z International audience The study provides detailed information on the differences in the structural, thermal and degradation properties of poly(ε-caprolactone) synthesized in two different ionic liquids, 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [bmim][NTf2], regarding its further usage in the pharmaceutical field. The polymer structure confirms the presence of both linear polymer chains with end-functional hydroxyl groups allowing covalent coupling of the therapeutic agents, and cyclic macromolecules, both affecting the degree of crystallinity of polymer. The highest macrocyclic content (64%) after 7 days of polymerization at 80 8C was observed for [bmim][NTf2]. For [bmim][PF6], the macrocyclic content value was not dependent on the reaction time and remained at a similar level (10–14% at 80 8C). The results of degradation test revealed that hydrolytic degradation of ester bonds is more pronounced for PCLs synthesized in [bmim][NTf2], due to their lower degree of crystallinity compared with PCLs obtained in [bmim][PF6]. A high purity, low polydispersity index of the obtained polymers and high yield of the process (ca., 90%) indicate that ionic liquids seem to be promising solvents for the synthesis of biomedical polymers. Article in Journal/Newspaper Antarc* Antarctica Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Journal of Applied Polymer Science 133 31 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
Properties and characterization Polyesters Ionic liquids Degradation Drug delivery systems [CHIM.POLY]Chemical Sciences/Polymers |
spellingShingle |
Properties and characterization Polyesters Ionic liquids Degradation Drug delivery systems [CHIM.POLY]Chemical Sciences/Polymers Piotrowska, Urszula Sobczak, Marcin Oledzka, Ewa Combes, Christèle Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
topic_facet |
Properties and characterization Polyesters Ionic liquids Degradation Drug delivery systems [CHIM.POLY]Chemical Sciences/Polymers |
description |
International audience The study provides detailed information on the differences in the structural, thermal and degradation properties of poly(ε-caprolactone) synthesized in two different ionic liquids, 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6] and 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide [bmim][NTf2], regarding its further usage in the pharmaceutical field. The polymer structure confirms the presence of both linear polymer chains with end-functional hydroxyl groups allowing covalent coupling of the therapeutic agents, and cyclic macromolecules, both affecting the degree of crystallinity of polymer. The highest macrocyclic content (64%) after 7 days of polymerization at 80 8C was observed for [bmim][NTf2]. For [bmim][PF6], the macrocyclic content value was not dependent on the reaction time and remained at a similar level (10–14% at 80 8C). The results of degradation test revealed that hydrolytic degradation of ester bonds is more pronounced for PCLs synthesized in [bmim][NTf2], due to their lower degree of crystallinity compared with PCLs obtained in [bmim][PF6]. A high purity, low polydispersity index of the obtained polymers and high yield of the process (ca., 90%) indicate that ionic liquids seem to be promising solvents for the synthesis of biomedical polymers. |
author2 |
Medical University of Warsaw - Poland Kazimierz Pulaski University of Technology and Humanities in Radom Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT) Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3) Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP) Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC) |
format |
Article in Journal/Newspaper |
author |
Piotrowska, Urszula Sobczak, Marcin Oledzka, Ewa Combes, Christèle |
author_facet |
Piotrowska, Urszula Sobczak, Marcin Oledzka, Ewa Combes, Christèle |
author_sort |
Piotrowska, Urszula |
title |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_short |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_full |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_fullStr |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_full_unstemmed |
Effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of Candida antarctica lipase B |
title_sort |
effect of ionic liquids on the structural, thermal and in vitro degradation properties of poly(ε-caprolactone) synthesized in the presence of candida antarctica lipase b |
publisher |
HAL CCSD |
publishDate |
2016 |
url |
https://hal.archives-ouvertes.fr/hal-01644363 https://hal.archives-ouvertes.fr/hal-01644363/document https://hal.archives-ouvertes.fr/hal-01644363/file/Piotrowska_18209.pdf https://doi.org/10.1002/app.43728 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
ISSN: 0021-8995 EISSN: 1097-4628 Journal of Applied Polymer Science https://hal.archives-ouvertes.fr/hal-01644363 Journal of Applied Polymer Science, Wiley, 2016, 133 (31), ⟨10.1002/app.43728⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1002/app.43728 hal-01644363 https://hal.archives-ouvertes.fr/hal-01644363 https://hal.archives-ouvertes.fr/hal-01644363/document https://hal.archives-ouvertes.fr/hal-01644363/file/Piotrowska_18209.pdf doi:10.1002/app.43728 OATAO: 18209 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1002/app.43728 |
container_title |
Journal of Applied Polymer Science |
container_volume |
133 |
container_issue |
31 |
_version_ |
1766021067928764416 |