Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot (Scophthalmus maximus)
Disease resistance-related traits have received increasing importance in aquaculture breeding programs worldwide. Currently, genomic information offers new possibilities in breeding to address the improvement of this kind of traits. The turbot is one of the most promising European aquaculture specie...
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Online Access: | https://hal.archives-ouvertes.fr/hal-01465160 https://doi.org/10.1111/j.1365-2052.2012.02385.x |
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ftccsdartic:oai:HAL:hal-01465160v1 2023-05-15T18:15:52+02:00 Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot (Scophthalmus maximus) Rodríguez-Ramilo, Silvia Teresa Fernández, J. TORO, M.A. Bouza, C. Hermida, M. Fernández, C. Pardo, B.G. Cabaleiro, S. Martínez, P. Dept Bioquim Genet & Inmuno Universidade de Vigo Dept Mejora Genet Anim Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Universidad Politécnica de Madrid (UPM) University of Santiago de Compostela Universidade de Santiago de Compostela Spain (USC ) Cluster Acuicultura Galicia (CETGA) 2013 https://hal.archives-ouvertes.fr/hal-01465160 https://doi.org/10.1111/j.1365-2052.2012.02385.x en eng HAL CCSD Wiley-Blackwell info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2052.2012.02385.x info:eu-repo/semantics/altIdentifier/pmid/22690723 hal-01465160 https://hal.archives-ouvertes.fr/hal-01465160 doi:10.1111/j.1365-2052.2012.02385.x PRODINRA: 372763 PUBMED: 22690723 WOS: 000315920500004 ISSN: 0268-9146 EISSN: 1365-2052 Animal Genetics https://hal.archives-ouvertes.fr/hal-01465160 Animal Genetics, Wiley-Blackwell, 2013, 44 (2), pp.149-157. ⟨10.1111/j.1365-2052.2012.02385.x⟩ qtl quantitative trait loci scuticociliatosis turbot maximum likelihood method linear regression method [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2013 ftccsdartic https://doi.org/10.1111/j.1365-2052.2012.02385.x 2021-07-24T23:48:49Z Disease resistance-related traits have received increasing importance in aquaculture breeding programs worldwide. Currently, genomic information offers new possibilities in breeding to address the improvement of this kind of traits. The turbot is one of the most promising European aquaculture species, and Philasterides dicentrarchi is a scuticociliate parasite causing fatal disease in farmed turbot. An appealing approach to fight against disease is to achieve a more robust broodstock, which could prevent or diminish the devastating effects of scuticociliatosis on farmed individuals. In the present study, a genome scan for quantitative trait loci (QTL) affecting resistance and survival time to P. dicentrarchi in four turbot families was carried out. The objectives were to identify QTL using different statistical approaches [linear regression (LR) and maximum likelihood (ML)] and to locate significantly associated markers for their application in genetic breeding strategies. Several genomic regions controlling resistance and survival time to P. dicentrarchi were detected. When analyzing each family separately, significant QTL for resistance were identified by the LR method in two linkage groups (LG1 and LG9) and for survival time in LG1, while the ML methodology identified QTL for resistance in LG9 and LG23 and for survival time in LG6 and LG23. The analysis of the total data set identified an additional significant QTL for resistance and survival time in LG3 with the LR method. Significant association between disease resistance-related traits and genotypes was detected for several markers, a single one explaining up to 22% of the phenotypic variance. Obtained results will be essential to identify candidate genes for resistance and to apply them in marker-assisted selection programs to improve turbot production. Article in Journal/Newspaper Scophthalmus maximus Turbot Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Animal Genetics 44 2 149 157 |
institution |
Open Polar |
collection |
Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
op_collection_id |
ftccsdartic |
language |
English |
topic |
qtl quantitative trait loci scuticociliatosis turbot maximum likelihood method linear regression method [SDV]Life Sciences [q-bio] |
spellingShingle |
qtl quantitative trait loci scuticociliatosis turbot maximum likelihood method linear regression method [SDV]Life Sciences [q-bio] Rodríguez-Ramilo, Silvia Teresa Fernández, J. TORO, M.A. Bouza, C. Hermida, M. Fernández, C. Pardo, B.G. Cabaleiro, S. Martínez, P. Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot (Scophthalmus maximus) |
topic_facet |
qtl quantitative trait loci scuticociliatosis turbot maximum likelihood method linear regression method [SDV]Life Sciences [q-bio] |
description |
Disease resistance-related traits have received increasing importance in aquaculture breeding programs worldwide. Currently, genomic information offers new possibilities in breeding to address the improvement of this kind of traits. The turbot is one of the most promising European aquaculture species, and Philasterides dicentrarchi is a scuticociliate parasite causing fatal disease in farmed turbot. An appealing approach to fight against disease is to achieve a more robust broodstock, which could prevent or diminish the devastating effects of scuticociliatosis on farmed individuals. In the present study, a genome scan for quantitative trait loci (QTL) affecting resistance and survival time to P. dicentrarchi in four turbot families was carried out. The objectives were to identify QTL using different statistical approaches [linear regression (LR) and maximum likelihood (ML)] and to locate significantly associated markers for their application in genetic breeding strategies. Several genomic regions controlling resistance and survival time to P. dicentrarchi were detected. When analyzing each family separately, significant QTL for resistance were identified by the LR method in two linkage groups (LG1 and LG9) and for survival time in LG1, while the ML methodology identified QTL for resistance in LG9 and LG23 and for survival time in LG6 and LG23. The analysis of the total data set identified an additional significant QTL for resistance and survival time in LG3 with the LR method. Significant association between disease resistance-related traits and genotypes was detected for several markers, a single one explaining up to 22% of the phenotypic variance. Obtained results will be essential to identify candidate genes for resistance and to apply them in marker-assisted selection programs to improve turbot production. |
author2 |
Dept Bioquim Genet & Inmuno Universidade de Vigo Dept Mejora Genet Anim Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Universidad Politécnica de Madrid (UPM) University of Santiago de Compostela Universidade de Santiago de Compostela Spain (USC ) Cluster Acuicultura Galicia (CETGA) |
format |
Article in Journal/Newspaper |
author |
Rodríguez-Ramilo, Silvia Teresa Fernández, J. TORO, M.A. Bouza, C. Hermida, M. Fernández, C. Pardo, B.G. Cabaleiro, S. Martínez, P. |
author_facet |
Rodríguez-Ramilo, Silvia Teresa Fernández, J. TORO, M.A. Bouza, C. Hermida, M. Fernández, C. Pardo, B.G. Cabaleiro, S. Martínez, P. |
author_sort |
Rodríguez-Ramilo, Silvia Teresa |
title |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot (Scophthalmus maximus) |
title_short |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot (Scophthalmus maximus) |
title_full |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot (Scophthalmus maximus) |
title_fullStr |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot (Scophthalmus maximus) |
title_full_unstemmed |
Uncovering QTL for resistance and survival time to Philasterides dicentrarchi in turbot (Scophthalmus maximus) |
title_sort |
uncovering qtl for resistance and survival time to philasterides dicentrarchi in turbot (scophthalmus maximus) |
publisher |
HAL CCSD |
publishDate |
2013 |
url |
https://hal.archives-ouvertes.fr/hal-01465160 https://doi.org/10.1111/j.1365-2052.2012.02385.x |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
ISSN: 0268-9146 EISSN: 1365-2052 Animal Genetics https://hal.archives-ouvertes.fr/hal-01465160 Animal Genetics, Wiley-Blackwell, 2013, 44 (2), pp.149-157. ⟨10.1111/j.1365-2052.2012.02385.x⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1365-2052.2012.02385.x info:eu-repo/semantics/altIdentifier/pmid/22690723 hal-01465160 https://hal.archives-ouvertes.fr/hal-01465160 doi:10.1111/j.1365-2052.2012.02385.x PRODINRA: 372763 PUBMED: 22690723 WOS: 000315920500004 |
op_doi |
https://doi.org/10.1111/j.1365-2052.2012.02385.x |
container_title |
Animal Genetics |
container_volume |
44 |
container_issue |
2 |
container_start_page |
149 |
op_container_end_page |
157 |
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1766189110831087616 |