Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n)
International audience 2,5-Dimethoxy-4-propylphenethylamine (2C-P) is a hallucinogenic designer drug of the phenethylamine class, the so-called 2Cs, named according to the ethyl spacer between the nitrogen and the aromatic ring. The aims of the present work were to identify the phases I and II metab...
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ftccsdartic:oai:HAL:hal-01389237v1 2023-05-15T15:52:42+02:00 Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n) Wink, Carina Meyer, Markus Braun, Tina Turcant, Alain Maurer, Hans Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP) Université d'Angers (UA) 2015 https://hal.archives-ouvertes.fr/hal-01389237 https://doi.org/10.1007/s00216-014-8083-2 en eng HAL CCSD Springer Verlag info:eu-repo/semantics/altIdentifier/doi/10.1007/s00216-014-8083-2 hal-01389237 https://hal.archives-ouvertes.fr/hal-01389237 doi:10.1007/s00216-014-8083-2 OKINA: ua11183 ISSN: 1618-2642 EISSN: 1618-2650 Analytical and Bioanalytical Chemistry https://hal.archives-ouvertes.fr/hal-01389237 Analytical and Bioanalytical Chemistry, Springer Verlag, 2015, 407 (3), pp.831-843. ⟨10.1007/s00216-014-8083-2⟩ 2C-P GC-MS LC-HR-MS n Metabolism Phenethylamine derivatives [CHIM]Chemical Sciences info:eu-repo/semantics/article Journal articles 2015 ftccsdartic https://doi.org/10.1007/s00216-014-8083-2 2021-10-24T09:44:59Z International audience 2,5-Dimethoxy-4-propylphenethylamine (2C-P) is a hallucinogenic designer drug of the phenethylamine class, the so-called 2Cs, named according to the ethyl spacer between the nitrogen and the aromatic ring. The aims of the present work were to identify the phases I and II metabolites of 2C-P. In addition, the detectability of 2C-P and its metabolites in urine as proof of an intake in clinical or forensic cases was tested. According to the identified metabolites, the following pathways were proposed: N-acetylation; deamination followed by reduction to the corresponding alcohol and oxidation to carbonic acid; mono- and bis-hydroxylation at different positions; mono- and bis-O-demethylation, followed by glucuronidation, sulfation, or both; and combination of these steps. Proof of an intake of a common user's dose of 2C-P was possible by both standard urine screening approaches, the GC-MS as well as the LC-MS(n) approach. Article in Journal/Newspaper Carbonic acid Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Analytical and Bioanalytical Chemistry 407 3 831 843 |
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Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
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ftccsdartic |
language |
English |
topic |
2C-P GC-MS LC-HR-MS n Metabolism Phenethylamine derivatives [CHIM]Chemical Sciences |
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2C-P GC-MS LC-HR-MS n Metabolism Phenethylamine derivatives [CHIM]Chemical Sciences Wink, Carina Meyer, Markus Braun, Tina Turcant, Alain Maurer, Hans Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n) |
topic_facet |
2C-P GC-MS LC-HR-MS n Metabolism Phenethylamine derivatives [CHIM]Chemical Sciences |
description |
International audience 2,5-Dimethoxy-4-propylphenethylamine (2C-P) is a hallucinogenic designer drug of the phenethylamine class, the so-called 2Cs, named according to the ethyl spacer between the nitrogen and the aromatic ring. The aims of the present work were to identify the phases I and II metabolites of 2C-P. In addition, the detectability of 2C-P and its metabolites in urine as proof of an intake in clinical or forensic cases was tested. According to the identified metabolites, the following pathways were proposed: N-acetylation; deamination followed by reduction to the corresponding alcohol and oxidation to carbonic acid; mono- and bis-hydroxylation at different positions; mono- and bis-O-demethylation, followed by glucuronidation, sulfation, or both; and combination of these steps. Proof of an intake of a common user's dose of 2C-P was possible by both standard urine screening approaches, the GC-MS as well as the LC-MS(n) approach. |
author2 |
Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP) Université d'Angers (UA) |
format |
Article in Journal/Newspaper |
author |
Wink, Carina Meyer, Markus Braun, Tina Turcant, Alain Maurer, Hans |
author_facet |
Wink, Carina Meyer, Markus Braun, Tina Turcant, Alain Maurer, Hans |
author_sort |
Wink, Carina |
title |
Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n) |
title_short |
Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n) |
title_full |
Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n) |
title_fullStr |
Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n) |
title_full_unstemmed |
Biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2C-P) studied in urine by GC-MS, LC-MS(n), and LC-high-resolution-MS(n) |
title_sort |
biotransformation and detectability of the designer drug 2,5-dimethoxy-4-propylphenethylamine (2c-p) studied in urine by gc-ms, lc-ms(n), and lc-high-resolution-ms(n) |
publisher |
HAL CCSD |
publishDate |
2015 |
url |
https://hal.archives-ouvertes.fr/hal-01389237 https://doi.org/10.1007/s00216-014-8083-2 |
genre |
Carbonic acid |
genre_facet |
Carbonic acid |
op_source |
ISSN: 1618-2642 EISSN: 1618-2650 Analytical and Bioanalytical Chemistry https://hal.archives-ouvertes.fr/hal-01389237 Analytical and Bioanalytical Chemistry, Springer Verlag, 2015, 407 (3), pp.831-843. ⟨10.1007/s00216-014-8083-2⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00216-014-8083-2 hal-01389237 https://hal.archives-ouvertes.fr/hal-01389237 doi:10.1007/s00216-014-8083-2 OKINA: ua11183 |
op_doi |
https://doi.org/10.1007/s00216-014-8083-2 |
container_title |
Analytical and Bioanalytical Chemistry |
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407 |
container_issue |
3 |
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831 |
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843 |
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1766387805518299136 |