Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses
International audience AbstractHerpesvirus infection causes disease of variable severity in many species, including cetaceans. However, little is known about herpesvirus infection in harbor porpoises (Phocoena phocoena), despite being widespread in temperate coastal waters of the Northern Hemisphere...
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ftccsdartic:oai:HAL:hal-01341480v1 2023-05-15T17:59:07+02:00 Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses van Elk, Cornelis van de Bildt, Marco van Run, Peter de Jong, Anton Getu, Sarah Verjans, Georges Osterhaus, Albert Kuiken, Thijs 2016-12 https://hal.archives-ouvertes.fr/hal-01341480 https://hal.archives-ouvertes.fr/hal-01341480/document https://hal.archives-ouvertes.fr/hal-01341480/file/13567_2016_Article_310.pdf https://doi.org/10.1186/s13567-016-0310-8 en eng HAL CCSD BioMed Central info:eu-repo/semantics/altIdentifier/doi/10.1186/s13567-016-0310-8 hal-01341480 https://hal.archives-ouvertes.fr/hal-01341480 https://hal.archives-ouvertes.fr/hal-01341480/document https://hal.archives-ouvertes.fr/hal-01341480/file/13567_2016_Article_310.pdf doi:10.1186/s13567-016-0310-8 info:eu-repo/semantics/OpenAccess ISSN: 0928-4249 EISSN: 1297-9716 Veterinary Research https://hal.archives-ouvertes.fr/hal-01341480 Veterinary Research, BioMed Central, 2016, 47 (1), pp.28. ⟨10.1186/s13567-016-0310-8⟩ [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2016 ftccsdartic https://doi.org/10.1186/s13567-016-0310-8 2021-02-21T01:25:54Z International audience AbstractHerpesvirus infection causes disease of variable severity in many species, including cetaceans. However, little is known about herpesvirus infection in harbor porpoises (Phocoena phocoena), despite being widespread in temperate coastal waters of the Northern Hemisphere. Therefore, we examined harbor porpoises that stranded alive in the Netherlands, Belgium, and Germany between 2000 and 2014 for herpesvirus infection and associated disease. Porpoises that died or had to be euthanized were autopsied, and samples were collected for virological and pathological analyses. We found one known herpesvirus (Phocoena phocoena herpesvirus type 1, PPHV-1)—a gammaherpesvirus—and two novel herpesviruses (PPHV-2 and PPHV-3)—both alphaherpesviruses—in these porpoises. A genital plaque, in which PPHV-1 was detected, occurred in 1% (1/117) of porpoises. The plaque was characterized by epithelial hyperplasia and intranuclear inclusion bodies that contained herpesvirus-like particles, and that stained positive by a PPHV-1-specific in situ hybridization test. PPHV-2 occurred in the brain of 2% (1/74) of porpoises. This infection was associated with lymphocytic encephalitis, characterized by neuronal necrosis and intranuclear inclusion bodies containing herpesvirus-like particles. PPHV-3 had a prevalence of 5% (4/74) in brain tissue, 5% (2/43) in blowhole swabs, and 2% (1/43) in genital swabs, but was not associated with disease. Phylogenetically, PPHV-1 was identical to a previously reported herpesvirus from a harbor porpoise, PPHV-2 showed closest identity with two herpesviruses from dolphins, and PPHV-3 showed closest identity with a cervid herpesvirus. In conclusion, harbor porpoises may be infected with at least three different herpesviruses, one of which can cause clinically severe neurological disease. Article in Journal/Newspaper Phocoena phocoena Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Veterinary Research 47 1 |
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Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
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ftccsdartic |
language |
English |
topic |
[SDV]Life Sciences [q-bio] |
spellingShingle |
[SDV]Life Sciences [q-bio] van Elk, Cornelis van de Bildt, Marco van Run, Peter de Jong, Anton Getu, Sarah Verjans, Georges Osterhaus, Albert Kuiken, Thijs Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses |
topic_facet |
[SDV]Life Sciences [q-bio] |
description |
International audience AbstractHerpesvirus infection causes disease of variable severity in many species, including cetaceans. However, little is known about herpesvirus infection in harbor porpoises (Phocoena phocoena), despite being widespread in temperate coastal waters of the Northern Hemisphere. Therefore, we examined harbor porpoises that stranded alive in the Netherlands, Belgium, and Germany between 2000 and 2014 for herpesvirus infection and associated disease. Porpoises that died or had to be euthanized were autopsied, and samples were collected for virological and pathological analyses. We found one known herpesvirus (Phocoena phocoena herpesvirus type 1, PPHV-1)—a gammaherpesvirus—and two novel herpesviruses (PPHV-2 and PPHV-3)—both alphaherpesviruses—in these porpoises. A genital plaque, in which PPHV-1 was detected, occurred in 1% (1/117) of porpoises. The plaque was characterized by epithelial hyperplasia and intranuclear inclusion bodies that contained herpesvirus-like particles, and that stained positive by a PPHV-1-specific in situ hybridization test. PPHV-2 occurred in the brain of 2% (1/74) of porpoises. This infection was associated with lymphocytic encephalitis, characterized by neuronal necrosis and intranuclear inclusion bodies containing herpesvirus-like particles. PPHV-3 had a prevalence of 5% (4/74) in brain tissue, 5% (2/43) in blowhole swabs, and 2% (1/43) in genital swabs, but was not associated with disease. Phylogenetically, PPHV-1 was identical to a previously reported herpesvirus from a harbor porpoise, PPHV-2 showed closest identity with two herpesviruses from dolphins, and PPHV-3 showed closest identity with a cervid herpesvirus. In conclusion, harbor porpoises may be infected with at least three different herpesviruses, one of which can cause clinically severe neurological disease. |
format |
Article in Journal/Newspaper |
author |
van Elk, Cornelis van de Bildt, Marco van Run, Peter de Jong, Anton Getu, Sarah Verjans, Georges Osterhaus, Albert Kuiken, Thijs |
author_facet |
van Elk, Cornelis van de Bildt, Marco van Run, Peter de Jong, Anton Getu, Sarah Verjans, Georges Osterhaus, Albert Kuiken, Thijs |
author_sort |
van Elk, Cornelis |
title |
Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses |
title_short |
Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses |
title_full |
Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses |
title_fullStr |
Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses |
title_full_unstemmed |
Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses |
title_sort |
central nervous system disease and genital disease in harbor porpoises (phocoena phocoena) are associated with different herpesviruses |
publisher |
HAL CCSD |
publishDate |
2016 |
url |
https://hal.archives-ouvertes.fr/hal-01341480 https://hal.archives-ouvertes.fr/hal-01341480/document https://hal.archives-ouvertes.fr/hal-01341480/file/13567_2016_Article_310.pdf https://doi.org/10.1186/s13567-016-0310-8 |
genre |
Phocoena phocoena |
genre_facet |
Phocoena phocoena |
op_source |
ISSN: 0928-4249 EISSN: 1297-9716 Veterinary Research https://hal.archives-ouvertes.fr/hal-01341480 Veterinary Research, BioMed Central, 2016, 47 (1), pp.28. ⟨10.1186/s13567-016-0310-8⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13567-016-0310-8 hal-01341480 https://hal.archives-ouvertes.fr/hal-01341480 https://hal.archives-ouvertes.fr/hal-01341480/document https://hal.archives-ouvertes.fr/hal-01341480/file/13567_2016_Article_310.pdf doi:10.1186/s13567-016-0310-8 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1186/s13567-016-0310-8 |
container_title |
Veterinary Research |
container_volume |
47 |
container_issue |
1 |
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1766167866448543744 |