Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon
International audience AbstractAll viruses infecting fish must cross the surface mucosal barrier to successfully enter a host. Infectious salmon anaemia virus (ISAV), the causative agent of the economically important infectious salmon anaemia (ISA) in Atlantic salmon, Salmo salar L., has been shown...
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ftccsdartic:oai:HAL:hal-01341431v1 2023-05-15T15:30:29+02:00 Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon Aamelfot, Maria McBeath, Alastair Christiansen, Debes H. Matejusova, Iveta Falk, Knut 2015-12 https://hal.archives-ouvertes.fr/hal-01341431 https://hal.archives-ouvertes.fr/hal-01341431/document https://hal.archives-ouvertes.fr/hal-01341431/file/13567_2015_Article_265.pdf https://doi.org/10.1186/s13567-015-0265-1 en eng HAL CCSD BioMed Central info:eu-repo/semantics/altIdentifier/doi/10.1186/s13567-015-0265-1 hal-01341431 https://hal.archives-ouvertes.fr/hal-01341431 https://hal.archives-ouvertes.fr/hal-01341431/document https://hal.archives-ouvertes.fr/hal-01341431/file/13567_2015_Article_265.pdf doi:10.1186/s13567-015-0265-1 info:eu-repo/semantics/OpenAccess ISSN: 0928-4249 EISSN: 1297-9716 Veterinary Research https://hal.archives-ouvertes.fr/hal-01341431 Veterinary Research, BioMed Central, 2015, 46 (1), pp.120. ⟨10.1186/s13567-015-0265-1⟩ [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2015 ftccsdartic https://doi.org/10.1186/s13567-015-0265-1 2021-02-21T01:25:54Z International audience AbstractAll viruses infecting fish must cross the surface mucosal barrier to successfully enter a host. Infectious salmon anaemia virus (ISAV), the causative agent of the economically important infectious salmon anaemia (ISA) in Atlantic salmon, Salmo salar L., has been shown to use the gills as its entry point. However, other entry ports have not been investigated despite the expression of virus receptors on the surface of epithelial cells in the skin, the gastrointestinal (GI) tract and the conjunctiva. Here we investigate the ISAV mucosal infection in Atlantic salmon after experimental immersion (bath) challenge and in farmed fish collected from a confirmed outbreak of ISA in Norway. We show for the first time evidence of early replication in several mucosal surfaces in addition to the gills, including the pectoral fin, skin and GI tract suggesting several potential entry points for the virus. Initially, the infection is localized and primarily infecting epithelial cells, however at later stages it becomes systemic, infecting the endothelial cells lining the circulatory system. Viruses of low and high virulence used in the challenge revealed possible variation in virus progression during infection at the mucosal surfaces. Article in Journal/Newspaper Atlantic salmon Salmo salar Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Norway Veterinary Research 46 1 |
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Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
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ftccsdartic |
language |
English |
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[SDV]Life Sciences [q-bio] |
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[SDV]Life Sciences [q-bio] Aamelfot, Maria McBeath, Alastair Christiansen, Debes H. Matejusova, Iveta Falk, Knut Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
topic_facet |
[SDV]Life Sciences [q-bio] |
description |
International audience AbstractAll viruses infecting fish must cross the surface mucosal barrier to successfully enter a host. Infectious salmon anaemia virus (ISAV), the causative agent of the economically important infectious salmon anaemia (ISA) in Atlantic salmon, Salmo salar L., has been shown to use the gills as its entry point. However, other entry ports have not been investigated despite the expression of virus receptors on the surface of epithelial cells in the skin, the gastrointestinal (GI) tract and the conjunctiva. Here we investigate the ISAV mucosal infection in Atlantic salmon after experimental immersion (bath) challenge and in farmed fish collected from a confirmed outbreak of ISA in Norway. We show for the first time evidence of early replication in several mucosal surfaces in addition to the gills, including the pectoral fin, skin and GI tract suggesting several potential entry points for the virus. Initially, the infection is localized and primarily infecting epithelial cells, however at later stages it becomes systemic, infecting the endothelial cells lining the circulatory system. Viruses of low and high virulence used in the challenge revealed possible variation in virus progression during infection at the mucosal surfaces. |
format |
Article in Journal/Newspaper |
author |
Aamelfot, Maria McBeath, Alastair Christiansen, Debes H. Matejusova, Iveta Falk, Knut |
author_facet |
Aamelfot, Maria McBeath, Alastair Christiansen, Debes H. Matejusova, Iveta Falk, Knut |
author_sort |
Aamelfot, Maria |
title |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_short |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_full |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_fullStr |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_full_unstemmed |
Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon |
title_sort |
infectious salmon anaemia virus (isav) mucosal infection in atlantic salmon |
publisher |
HAL CCSD |
publishDate |
2015 |
url |
https://hal.archives-ouvertes.fr/hal-01341431 https://hal.archives-ouvertes.fr/hal-01341431/document https://hal.archives-ouvertes.fr/hal-01341431/file/13567_2015_Article_265.pdf https://doi.org/10.1186/s13567-015-0265-1 |
geographic |
Norway |
geographic_facet |
Norway |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
ISSN: 0928-4249 EISSN: 1297-9716 Veterinary Research https://hal.archives-ouvertes.fr/hal-01341431 Veterinary Research, BioMed Central, 2015, 46 (1), pp.120. ⟨10.1186/s13567-015-0265-1⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13567-015-0265-1 hal-01341431 https://hal.archives-ouvertes.fr/hal-01341431 https://hal.archives-ouvertes.fr/hal-01341431/document https://hal.archives-ouvertes.fr/hal-01341431/file/13567_2015_Article_265.pdf doi:10.1186/s13567-015-0265-1 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1186/s13567-015-0265-1 |
container_title |
Veterinary Research |
container_volume |
46 |
container_issue |
1 |
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1766360927805898752 |