The new insights into the oyster antimicrobial defense: cellular, molecular and genetic view
International audience Oysters are sessile filter feeders that live in close association with abundant and diverse communities of microorganisms that form the oyster microbiota. In such an association, cellular and molecular mechanisms have evolved to maintain oyster homeostasis upon stressful condi...
Published in: | Fish & Shellfish Immunology |
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Online Access: | https://hal.archives-ouvertes.fr/hal-01162911 https://hal.archives-ouvertes.fr/hal-01162911/document https://hal.archives-ouvertes.fr/hal-01162911/file/Bachere-2015-FishShellFImmunol-TheNew.pdf https://doi.org/10.1016/j.fsi.2015.02.040 |
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ftccsdartic:oai:HAL:hal-01162911v1 2023-05-15T15:58:47+02:00 The new insights into the oyster antimicrobial defense: cellular, molecular and genetic view Bachère, Evelyne Rosa, Rafael Diego Schmitt, Paulina Poirier, Aurore Merou, Nicolas Charrière, Guillaume M Destoumieux-Garzon, Delphine Interactions Hôtes-Pathogènes-Environnements (IHPE) Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Perpignan Via Domitia (UPVD) Universidade Federal de Santa Catarina = Federal University of Santa Catarina Florianópolis (UFSC) 2015 https://hal.archives-ouvertes.fr/hal-01162911 https://hal.archives-ouvertes.fr/hal-01162911/document https://hal.archives-ouvertes.fr/hal-01162911/file/Bachere-2015-FishShellFImmunol-TheNew.pdf https://doi.org/10.1016/j.fsi.2015.02.040 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fsi.2015.02.040 hal-01162911 https://hal.archives-ouvertes.fr/hal-01162911 https://hal.archives-ouvertes.fr/hal-01162911/document https://hal.archives-ouvertes.fr/hal-01162911/file/Bachere-2015-FishShellFImmunol-TheNew.pdf doi:10.1016/j.fsi.2015.02.040 info:eu-repo/semantics/OpenAccess ISSN: 1050-4648 EISSN: 1095-9947 Fish and Shellfish Immunology https://hal.archives-ouvertes.fr/hal-01162911 Fish and Shellfish Immunology, Elsevier, 2015, 46 (1), pp.50-64. ⟨10.1016/j.fsi.2015.02.040⟩ Hemocyte Defensin Mollusk Immunity Antimicrobial peptide [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] info:eu-repo/semantics/article Journal articles 2015 ftccsdartic https://doi.org/10.1016/j.fsi.2015.02.040 2021-10-24T00:06:04Z International audience Oysters are sessile filter feeders that live in close association with abundant and diverse communities of microorganisms that form the oyster microbiota. In such an association, cellular and molecular mechanisms have evolved to maintain oyster homeostasis upon stressful conditions including infection and changing environments. We give here cellular and molecular insights into the Crassostrea gigas antimicrobial defense system with focus on antimicrobial peptides and proteins (AMPs). This review highlights the central role of the hemocytes in the modulation and control of oyster antimicrobial response. As vehicles for AMPs and other antimicrobial effectors, including reactive oxygen species (ROS), and together with epithelia, hemocytes provide the oyster with local defense reactions instead of systemic humoral ones. These reactions are largely based on phagocytosis but also, as recently described, on the extracellular release of antimicrobial histones (ETosis) which is triggered by ROS. Thus, ROS can signal danger and activate cellular responses in the oyster. From the current literature, AMP production/release could serve similar functions. We provide also new lights on the oyster genetic background that underlies a great diversity of AMP sequences but also an extraordinary individual polymorphism of AMP gene expression. We discuss here how this polymorphism could generate new immune functions, new pathogen resistances or support individual adaptation to environmental stresses Article in Journal/Newspaper Crassostrea gigas Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) Fish & Shellfish Immunology 46 1 50 64 |
institution |
Open Polar |
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Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
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ftccsdartic |
language |
English |
topic |
Hemocyte Defensin Mollusk Immunity Antimicrobial peptide [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] |
spellingShingle |
Hemocyte Defensin Mollusk Immunity Antimicrobial peptide [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] Bachère, Evelyne Rosa, Rafael Diego Schmitt, Paulina Poirier, Aurore Merou, Nicolas Charrière, Guillaume M Destoumieux-Garzon, Delphine The new insights into the oyster antimicrobial defense: cellular, molecular and genetic view |
topic_facet |
Hemocyte Defensin Mollusk Immunity Antimicrobial peptide [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] |
description |
International audience Oysters are sessile filter feeders that live in close association with abundant and diverse communities of microorganisms that form the oyster microbiota. In such an association, cellular and molecular mechanisms have evolved to maintain oyster homeostasis upon stressful conditions including infection and changing environments. We give here cellular and molecular insights into the Crassostrea gigas antimicrobial defense system with focus on antimicrobial peptides and proteins (AMPs). This review highlights the central role of the hemocytes in the modulation and control of oyster antimicrobial response. As vehicles for AMPs and other antimicrobial effectors, including reactive oxygen species (ROS), and together with epithelia, hemocytes provide the oyster with local defense reactions instead of systemic humoral ones. These reactions are largely based on phagocytosis but also, as recently described, on the extracellular release of antimicrobial histones (ETosis) which is triggered by ROS. Thus, ROS can signal danger and activate cellular responses in the oyster. From the current literature, AMP production/release could serve similar functions. We provide also new lights on the oyster genetic background that underlies a great diversity of AMP sequences but also an extraordinary individual polymorphism of AMP gene expression. We discuss here how this polymorphism could generate new immune functions, new pathogen resistances or support individual adaptation to environmental stresses |
author2 |
Interactions Hôtes-Pathogènes-Environnements (IHPE) Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Perpignan Via Domitia (UPVD) Universidade Federal de Santa Catarina = Federal University of Santa Catarina Florianópolis (UFSC) |
format |
Article in Journal/Newspaper |
author |
Bachère, Evelyne Rosa, Rafael Diego Schmitt, Paulina Poirier, Aurore Merou, Nicolas Charrière, Guillaume M Destoumieux-Garzon, Delphine |
author_facet |
Bachère, Evelyne Rosa, Rafael Diego Schmitt, Paulina Poirier, Aurore Merou, Nicolas Charrière, Guillaume M Destoumieux-Garzon, Delphine |
author_sort |
Bachère, Evelyne |
title |
The new insights into the oyster antimicrobial defense: cellular, molecular and genetic view |
title_short |
The new insights into the oyster antimicrobial defense: cellular, molecular and genetic view |
title_full |
The new insights into the oyster antimicrobial defense: cellular, molecular and genetic view |
title_fullStr |
The new insights into the oyster antimicrobial defense: cellular, molecular and genetic view |
title_full_unstemmed |
The new insights into the oyster antimicrobial defense: cellular, molecular and genetic view |
title_sort |
new insights into the oyster antimicrobial defense: cellular, molecular and genetic view |
publisher |
HAL CCSD |
publishDate |
2015 |
url |
https://hal.archives-ouvertes.fr/hal-01162911 https://hal.archives-ouvertes.fr/hal-01162911/document https://hal.archives-ouvertes.fr/hal-01162911/file/Bachere-2015-FishShellFImmunol-TheNew.pdf https://doi.org/10.1016/j.fsi.2015.02.040 |
genre |
Crassostrea gigas |
genre_facet |
Crassostrea gigas |
op_source |
ISSN: 1050-4648 EISSN: 1095-9947 Fish and Shellfish Immunology https://hal.archives-ouvertes.fr/hal-01162911 Fish and Shellfish Immunology, Elsevier, 2015, 46 (1), pp.50-64. ⟨10.1016/j.fsi.2015.02.040⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fsi.2015.02.040 hal-01162911 https://hal.archives-ouvertes.fr/hal-01162911 https://hal.archives-ouvertes.fr/hal-01162911/document https://hal.archives-ouvertes.fr/hal-01162911/file/Bachere-2015-FishShellFImmunol-TheNew.pdf doi:10.1016/j.fsi.2015.02.040 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1016/j.fsi.2015.02.040 |
container_title |
Fish & Shellfish Immunology |
container_volume |
46 |
container_issue |
1 |
container_start_page |
50 |
op_container_end_page |
64 |
_version_ |
1766394554744832000 |